Basidiobolomycosis

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Basidiobolomycosis
Basidiobolus (257 20).jpg
Basidiobolus ranarum : causative organism
Specialty Infectious disease [1]
Symptoms Firm painless nodule in skin, [2] tummy upset [3]
Complications Spread to local structures [2]
Usual onsetGradual/slow [2]
Causes B. ranarum [2]
Diagnostic method Medical imaging, biopsy, microscopy, culture, histopathology [2]
Differential diagnosis Inflammatory bowel disease [2]
Treatment Antifungals, surgery [4]
Medication Amphotericin B [4]
FrequencyRare [3]

Basidiobolomycosis is a fungal disease caused by Basidiobolus ranarum . [1] [5] It may appear as one or more painless firm nodules in the skin which becomes purplish with an edge that appears to be slowly growing outwards. [3] [5] A serious but less common type affects the stomach and intestine, which usually presents with abdominal pain, fever and a mass. [3]

Contents

B. ranarum, can be found in soil, decaying vegetables and has been isolated from insects, some reptiles, amphibians, and mammals. [2] The disease results from direct entry of the fungus through broken skin such as an insect bite or trauma, or eating contaminated food. [1] [3] It generally affects people who are well. [2]

Diagnosis is by medical imaging, biopsy, microscopy, culture and histopathology. [2] Treatment usually involves amphotericin B and surgery. [3] [4]

Although B. ranarum is found around the world, the disease Basidiobolomycosis is generally reported in tropical and subtropical areas of Africa, South America, Asia and Southwestern United States. [3] It is rare. [3] The first case in a human was reported from Indonesia in 1956 as a skin infection. [4]

Signs and symptoms

Basidiobolomycosis may appear as a firm nodule in the skin which becomes purplish with an edge that appears to be slowly growing outwards. [3] [5] It is generally painless but may feel itchy or burning. [3] [5] There can be one lesion or several, and usually on the arms or legs of children. [5] Pus may be present if a bacterial infection also occurs. [3] The infection can spread to nearby structures such as muscles, bones and lymph nodes. [2]

A serious but less common type affects the stomach and intestine, which usually presents with tummy ache, fever and a lump. [3] [6] Lymphoedema may occur. [3] [4]

Mechanism

Basidiobolomycosis is a type of Entomophthoromycosis, the other being conidiobolomycosis, and is caused by Basidiobolus ranarum , a fungus belonging to the order Entomophthorales. [2] B. ranarum has been found in soil, decaying vegetables and has been isolated from insects some reptiles, amphibians, and mammals. [2] The disease results from direct entry of the fungus through broken skin such as an insect bite or trauma, or eating contaminated food. [1] [3] Diabetes may be a risk factor. [3] The exact way in which infection results is not completely understood. [3]

Diagnosis

Diagnosis is by culture and biopsy. [4]

A review in 2015 showed that the most common finding on imaging of the abdomen was a mass in the bowel, the liver, or multiple sites and bowel wall thickening. Initially, many were considered to have either a cancer of the bowel or Crohns disease. [7] [8]

Treatment

Treatment usually involves itraconazole or amphotericin B, combined with surgical debridement. [4] Bowel involvement may be better treated with voriconazole. [2]

Epidemiology

The condition is rare but emerging. [3] Men and children are affected more than females. [3] The disease is generally reported in tropical and subtropical areas of Africa, South America, Asia and several cases in Southwestern United States. [2] [3]

History

The first case in a human was reported from Indonesia as a skin infection in 1956. [4] In 1964, the first case involving stomach and intestine was reported. [4]

Society and culture

Cases among gardeners in Arizona, US, may indicate an occupational hazard, but is unproven. [4]

Other animals

Basidiobolomycosis has been reported in a dog. [9]

Related Research Articles

<span class="mw-page-title-main">Candidiasis</span> Fungal infection due to any type of Candida

Candidiasis is a fungal infection due to any type of Candida. When it affects the mouth, in some countries it is commonly called thrush. Signs and symptoms include white patches on the tongue or other areas of the mouth and throat. Other symptoms may include soreness and problems swallowing. When it affects the vagina, it may be referred to as a yeast infection or thrush. Signs and symptoms include genital itching, burning, and sometimes a white "cottage cheese-like" discharge from the vagina. Yeast infections of the penis are less common and typically present with an itchy rash. Very rarely, yeast infections may become invasive, spreading to other parts of the body. This may result in fevers along with other symptoms depending on the parts involved.

<span class="mw-page-title-main">Crohn's disease</span> Type of inflammatory bowel disease

Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea, fever, abdominal distension, and weight loss. Complications outside of the gastrointestinal tract may include anemia, skin rashes, arthritis, inflammation of the eye, and fatigue. The skin rashes may be due to infections as well as pyoderma gangrenosum or erythema nodosum. Bowel obstruction may occur as a complication of chronic inflammation, and those with the disease are at greater risk of colon cancer and small bowel cancer.

<span class="mw-page-title-main">Gastrointestinal tract</span> Organ system within humans and other animals

The gastrointestinal tract is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines. Food taken in through the mouth is digested to extract nutrients and absorb energy, and the waste expelled at the anus as feces. Gastrointestinal is an adjective meaning of or pertaining to the stomach and intestines.

<span class="mw-page-title-main">Coccidioidomycosis</span> Fungal infection

Coccidioidomycosis, commonly known as cocci, Valley fever, as well as California fever, desert rheumatism, or San Joaquin Valley fever, is a mammalian fungal disease caused by Coccidioides immitis or Coccidioides posadasii. Coccidioidomycosis is endemic in certain parts of the United States in Arizona, California, Nevada, New Mexico, Texas, Utah, and northern Mexico.

Enteritis is inflammation of the small intestine. It is most commonly caused by food or drink contaminated with pathogenic microbes, such as serratia, but may have other causes such as NSAIDs, radiation therapy as well as autoimmune conditions like Crohn's disease and celiac disease. Symptoms include abdominal pain, cramping, diarrhea, dehydration, and fever. Related diseases of the gastrointestinal system include inflammation of the stomach and large intestine.

<span class="mw-page-title-main">Upper gastrointestinal series</span> Radiographs used to examine abnormalities of the digestive system excluding the colon

An upper gastrointestinal series, also called a barium swallow, barium study, or barium meal, is a series of radiographs used to examine the gastrointestinal tract for abnormalities. A contrast medium, usually a radiocontrast agent such as barium sulfate mixed with water, is ingested or instilled into the gastrointestinal tract, and X-rays are used to create radiographs of the regions of interest. The barium enhances the visibility of the relevant parts of the gastrointestinal tract by coating the inside wall of the tract and appearing white on the film. This in combination with other plain radiographs allows for the imaging of parts of the upper gastrointestinal tract such as the pharynx, larynx, esophagus, stomach, and small intestine such that the inside wall lining, size, shape, contour, and patency are visible to the examiner. With fluoroscopy, it is also possible to visualize the functional movement of examined organs such as swallowing, peristalsis, or sphincter closure. Depending on the organs to be examined, barium radiographs can be classified into "barium swallow", "barium meal", "barium follow-through", and "enteroclysis". To further enhance the quality of images, air or gas is sometimes introduced into the gastrointestinal tract in addition to barium, and this procedure is called double-contrast imaging. In this case the gas is referred to as the negative contrast medium. Traditionally the images produced with barium contrast are made with plain-film radiography, but computed tomography is also used in combination with barium contrast, in which case the procedure is called "CT enterography".

<span class="mw-page-title-main">Gastrointestinal disease</span> Medical condition

Gastrointestinal diseases refer to diseases involving the gastrointestinal tract, namely the esophagus, stomach, small intestine, large intestine and rectum, and the accessory organs of digestion, the liver, gallbladder, and pancreas.

<span class="mw-page-title-main">Zygomycosis</span> Medical condition

Zygomycosis is the broadest term to refer to infections caused by bread mold fungi of the zygomycota phylum. However, because zygomycota has been identified as polyphyletic, and is not included in modern fungal classification systems, the diseases that zygomycosis can refer to are better called by their specific names: mucormycosis, phycomycosis and basidiobolomycosis. These rare yet serious and potentially life-threatening fungal infections usually affect the face or oropharyngeal cavity. Zygomycosis type infections are most often caused by common fungi found in soil and decaying vegetation. While most individuals are exposed to the fungi on a regular basis, those with immune disorders (immunocompromised) are more prone to fungal infection. These types of infections are also common after natural disasters, such as tornadoes or earthquakes, where people have open wounds that have become filled with soil or vegetative matter.

<span class="mw-page-title-main">Gastrointestinal perforation</span> Medical condition

Gastrointestinal perforation, also known as ruptured bowel, is a hole in the wall of part of the gastrointestinal tract. The gastrointestinal tract includes the esophagus, stomach, small intestine, and large intestine. Symptoms include severe abdominal pain and tenderness. When the hole is in the stomach or early part of the small intestine, the onset of pain is typically sudden while with a hole in the large intestine onset may be more gradual. The pain is usually constant in nature. Sepsis, with an increased heart rate, increased breathing rate, fever, and confusion may occur.

<span class="mw-page-title-main">Sporotrichosis</span> Medical condition

Sporotrichosis, also known as rose handler's disease, is a fungal infection that may be localised to skin, lungs, bone and joint, or become systemic. It presents with firm painless nodules that later ulcerate. Following initial exposure to Sporothrix schenckii, the disease typically progresses over a period of a week to several months. Serious complications may develop in people who have a weakened immune system.

<span class="mw-page-title-main">Abdominal distension</span> Physical symptom

Abdominal distension occurs when substances, such as air (gas) or fluid, accumulate in the abdomen causing its expansion. It is typically a symptom of an underlying disease or dysfunction in the body, rather than an illness in its own right. People with this condition often describe it as "feeling bloated". Affected people often experience a sensation of fullness, abdominal pressure, and sometimes nausea, pain, or cramping. In the most extreme cases, upward pressure on the diaphragm and lungs can also cause shortness of breath. Through a variety of causes, bloating is most commonly due to buildup of gas in the stomach, small intestine, or colon. The pressure sensation is often relieved, or at least lessened, by belching or flatulence. Medications that settle gas in the stomach and intestines are also commonly used to treat the discomfort and lessen the abdominal distension.

<span class="mw-page-title-main">Lymphoma in animals</span>

Lymphoma (lymphosarcoma) in animals is a type of cancer defined by a proliferation of malignant lymphocytes within solid organs such as the lymph nodes, bone marrow, liver and spleen. The disease also may occur in the eye, skin, and gastrointestinal tract.

Phycomycosis is an uncommon condition of the gastrointestinal tract and skin most commonly found in dogs and horses. The condition is caused by a variety of molds and fungi, and individual forms include pythiosis, zygomycosis, and lagenidiosis. Pythiosis is the most common type and is caused by Pythium, a type of water mould. Zygomycosis can also be caused by two types of zygomycetes, Entomophthorales and Mucorales. The latter type of zygomycosis is also referred to as mucormycosis. Lagenidiosis is caused by a Lagenidium species, which like Pythium is a water mould. Since both pythiosis and lagenidiosis are caused by organisms from the class Oomycetes, they are sometimes collectively referred to as oomycosis.

<span class="mw-page-title-main">Pythiosis</span> Tropical disease caused by the oomycete Pythium insidiosum

Pythiosis is a rare and deadly tropical disease caused by the oomycete Pythium insidiosum. Long regarded as being caused by a fungus, the causative agent was not discovered until 1987. It occurs most commonly in horses, dogs, and humans, with isolated cases in other large mammals. The disease is contracted after exposure to stagnant fresh water such as swamps, ponds, lakes, and rice paddies. P. insidiosum is different from other members of the genus in that human and horse hair, skin, and decaying animal and plant tissue are chemoattractants for its zoospores. Additionally, it is the only member in the genus known to infect mammals, while other members are pathogenic to plants and are responsible for some well-known plant diseases.

Talaromycosis is a fungal infection that presents with painless skin lesions of face and neck, fever, anaemia, large lymph glands and liver.

<i>Basidiobolus ranarum</i> Species of fungus

Basidiobolus ranarum is a filamentous fungus with worldwide distribution. The fungus was first isolated by Eidam in 1886. It can saprophytically live in the intestines of mainly cold-blooded vertebrates and on decaying fruits and soil. The fungus prefers glucose as a carbon source and grows rapidly at room temperature. Basidiobolus ranarum is also known as a cause of subcutaneous zygomycosis, usually causing granulomatous infections on a host's limbs. Infections are generally geographically limited to tropical and subtropical regions such as East and West Africa. Subcutaneous zygomycosis caused by B. ranarum is a rare disease and predominantly affects children and males. Common subcutaneous zygomycosis shows characteristic features and is relatively easy to be diagnosed; while, certain rare cases might show non-specific clinical features that might pose a difficulty on its identification. Although disease caused by this fungus is known to resolve spontaneously on its own, there are a number of treatments available.

<span class="mw-page-title-main">Conidiobolomycosis</span> Fungal infection

Conidiobolomycosis is a rare long-term fungal infection that is typically found just under the skin of the nose, sinuses, cheeks and upper lips. It may present with a nose bleed or a blocked or runny nose. Typically there is a firm painless swelling which can slowly extend to the nasal bridge and eyes, sometimes causing facial disfigurement.

<span class="mw-page-title-main">Mucormycosis</span> Fungal infection

Mucormycosis, also known as black fungus, is a serious fungal infection that comes under fulminant fungal sinusitis, usually in people who are immunocompromised. It is curable only when diagnosed early. Symptoms depend on where in the body the infection occurs. It most commonly infects the nose, sinuses, eyes and brain resulting in a runny nose, one-sided facial swelling and pain, headache, fever, blurred vision, bulging or displacement of the eye (proptosis), and tissue death. Other forms of disease may infect the lungs, stomach and intestines, and skin.

<span class="mw-page-title-main">Abdominal tuberculosis</span> Medical condition

Abdominal tuberculosis is a type of extrapulmonary tuberculosis which involves the abdominal organs such as intestines, peritoneum and abdominal lymph nodes. It can either occur in isolation or along with a primary focus in patients with disseminated tuberculosis.

Emmonsiosis, also known as emergomycosis, is a systemic fungal infection that can affect the lungs, generally always affects the skin and can become widespread. The lesions in the skin look like small red bumps and patches with a dip, ulcer and dead tissue in the centre.

References

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