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Company type | Private |
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Industry | Biotechnology |
Founded | 2005Charlottesville |
Founder | Andreas Persidis |
Headquarters | Charlottesville, Virginia, US |
Area served | North America and Europe |
Key people | Aris Persidis (President) Andreas Persidis (CEO) |
Services | Drug repositioning |
Revenue | US$ 2.2 million (2010s) |
Number of employees | 8 |
Website | www |
Biovista Inc. is a private drug development services company based in Charlottesville, Virginia, US. Biovista's core business activities include drug repositioning and drug de-risking as well as disease cohort analysis, adverse event prediction and clinical hold analysis services. Biovista is also applying its technology platform to develop its own drug repositioning programs in the areas of central nervous system (CNS), diabetes/obesity, eye disorders, and oncology.[ citation needed ]
Biovista is an active participant of European Union co-funded R&D projects spanning areas such as post-genomic clinical trials research (ACGT project), [1] mutant mouse models for the investigation of Human Immunological Disease (MUGEN project ), semantic annotation and ontology driven text mining (PARMENIDES project) [2] and systematic knowledge discovery (ESPERONTO Project ).
The company derisks and repositions drugs using multidimensional profiles of pharmacologically relevant entities such as genes, diseases, drugs, pathways and cell types, to identify and rank potential adverse events and new indications for drugs in development, on the market, or generics.
Biovista is also creating software-based tools and services for Reagent companies, researchers in the Life sciences and the consumer and patient health areas.
Biovista's technology platform is based on the analysis and integration of Biomedical information available in the scientific literature using Biomedical text mining techniques. Pharmacologically-relevant areas include drug toxicity, drug mode of action, disease mechanisms and biological system interactions. Biovista Inc.’s technology platform integrates literature-based discovery algorithms with Semantic search technologies to identify and rank potential solutions to a variety of drug development related problems such as predicting the adverse events of compounds, identifying suitable biomarkers for diseases and discovering new indications for existing drugs or drug combinations.
Biovista’s correlation engine scans potential interactions between pharmacologically relevant entities resulting in a correlation database. The database itself is based on a proprietary design that combines the Relational database management system (RDBMS) model with the Object-Oriented model allowing researchers to obtain preliminary answers in weeks rather than years.
In January 2010, Biovista announced that the U.S. Food and Drug Administration (FDA) has licensed its technology platform to help analyze, identify, and better understand the way certain drugs can cause harmful side effects. Since the beginning of 2009, Biovista has started its own drug development programs based on repositioned compounds in CNS diseases, such as Multiple sclerosis and Epilepsy .
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Drug repositioning involves the investigation of existing drugs for new therapeutic purposes.
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The following outline is provided as an overview of and topical guide to clinical research:
Retigabine (INN) or ezogabine (USAN) is an anticonvulsant used as an adjunctive treatment for partial epilepsies in treatment-experienced adult patients. The drug was developed by Valeant Pharmaceuticals and GlaxoSmithKline. It was approved by the European Medicines Agency under the trade name Trobalt on March 28, 2011, and by the United States Food and Drug Administration (FDA), under the trade name Potiga, on June 10, 2011. Production was discontinued in June 2017.
Melior Discovery, Inc. is a private biopharmaceutical company based in Exton, Pennsylvania, USA.
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Abacavir/dolutegravir/lamivudine, sold under the brand name Triumeq among others, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS. It is a combination of three medications with different and complementary mechanisms of action: abacavir, dolutegravir and lamivudine.
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