CCNC (gene)

CCNC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RGF, 4F6S, 4F6U, 4F6W, 4F70, 4F7J, 4F7L, 4F7N, 4F7S, 4G6L, 4CRL, 5HBE, 5HBH, 5BNJ, 5HBJ, 5FGK, 5CEI, 5HNB, 5HVY, 5I5Z
Identifiers
Aliases	CCNC , CycC, cyclin C, hSRB11, SRB11
External IDs	OMIM: 123838 MGI: 1858199 HomoloGene: 3803 GeneCards: CCNC
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q16.2 Start 99,542,387 bp [1] End 99,568,825 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 A3 Start 21,727,701 bp [2] End 21,759,922 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland cavity of mouth corpus epididymis jejunal mucosa islet of Langerhans caput epididymis amniotic fluid body of pancreas kidney tubule vulva Top expressed in spermatid spermatocyte pineal gland ventral tegmental area medial vestibular nucleus dorsomedial hypothalamic nucleus lateral hypothalamus neural tube paraventricular nucleus of hypothalamus olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase regulator activity Cellular component mediator complex cyclin-dependent protein kinase holoenzyme complex nucleus nucleoplasm Biological process positive regulation of phosphorylation of RNA polymerase II C-terminal domain transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription by RNA polymerase II protein phosphorylation transcription, DNA-templated regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription by RNA polymerase II regulation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 892 51813 Ensembl ENSG00000112237 ENSMUSG00000028252 UniProt P24863 Q62447 RefSeq (mRNA) NM_001013399 NM_005190 NM_001363537 NM_001122982 NM_001290420 NM_001290422 NM_016746 RefSeq (protein) NP_001013417 NP_005181 NP_001350466 NP_001116454 NP_001277349 NP_001277351 NP_058026 Location (UCSC) Chr 6: 99.54 – 99.57 Mb Chr 4: 21.73 – 21.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cyclin-C is a protein that in humans is encoded by the CCNC gene. ^{[5] [6]}

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. ^[6]

Interactions

CCNC (gene) has been shown to interact with Estrogen receptor alpha ^[7] and Cyclin-dependent kinase 8. ^{[7] [8] [9] [10] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000112237 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028252 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lew DJ, Dulic V, Reed SI (Oct 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID   1833066. S2CID   12166415.
6. "Entrez Gene: CCNC cyclin C".
7. Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. Bibcode:2002PNAS...99.2642K. doi: 10.1073/pnas.261715899 . ISSN   0027-8424. PMC   122401 . PMID   11867769.
8. Zhang, Y; Iratni R; Erdjument-Bromage H; Tempst P; Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. doi: 10.1016/S0092-8674(00)80216-0 . ISSN   0092-8674. PMID   9150135.
9. Cho, H; Orphanides G; Sun X; Yang X J; Ogryzko V; Lees E; Nakatani Y; Reinberg D (Sep 1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. ISSN   0270-7306. PMC   109120 . PMID   9710619.
10. Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN   0270-7306. PMC   87123 . PMID   11416138.
11. Tassan, J P; Jaquenoud M; Léopold P; Schultz S J; Nigg E A (Sep 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. Bibcode:1995PNAS...92.8871T. doi: 10.1073/pnas.92.19.8871 . ISSN   0027-8424. PMC   41069 . PMID   7568034.

External links

• Human CCNC genome location and CCNC gene details page in the UCSC Genome Browser .

Further reading

• Nozawa T, Hatano M, Yamamoto H, Kwan T (1976). "Magnetic circular dichroism on the reversible oxygenation of dimethylmesoporphyrin-IX-atopyridinecobalt (II)". Bioinorganic Chemistry. 5 (3): 267–73. doi:10.1016/S0006-3061(00)82025-6. PMID   1260071.
• Tassan JP, Jaquenoud M, Léopold P, et al. (1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. Bibcode:1995PNAS...92.8871T. doi: 10.1073/pnas.92.19.8871 . PMC   41069 . PMID   7568034.
• Demetrick DJ, Matsumoto S, Hannon GJ, et al. (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet. Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID   7698009.
• Yoshizumi M, Lee WS, Hsieh CM, et al. (1995). "Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts". J. Clin. Invest. 95 (5): 2275–80. doi:10.1172/JCI117918. PMC   295840 . PMID   7738192.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Rickert P, Seghezzi W, Shanahan F, et al. (1996). "Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II". Oncogene. 12 (12): 2631–40. PMID   8700522.
• Li H, Lahti JM, Valentine M, et al. (1997). "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors". Genomics. 32 (2): 253–9. doi:10.1006/geno.1996.0112. PMID   8833152.
• Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. doi:10.1128/MCB.17.4.1817. PMC   232028 . PMID   9121429.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Neish AS, Anderson SF, Schlegel BP, et al. (1998). "Factors associated with the mammalian RNA polymerase II holoenzyme". Nucleic Acids Res. 26 (3): 847–53. doi:10.1093/nar/26.3.847. PMC   147327 . PMID   9443979.
• Cho H, Orphanides G, Sun X, et al. (1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. PMC   109120 . PMID   9710619.
• Sun X, Zhang Y, Cho H, et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell. 2 (2): 213–22. doi: 10.1016/S1097-2765(00)80131-8 . PMID   9734358.
• Gu W, Malik S, Ito M, et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell. 3 (1): 97–108. doi: 10.1016/S1097-2765(00)80178-1 . PMID   10024883.
• Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi: 10.1016/S1097-2765(00)80463-3 . PMID   10198638.
• Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID   10235266. S2CID   204992765.
• Wang G, Cantin GT, Stevens JL, Berk AJ (2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. PMC   87123 . PMID   11416138.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3" (PDF). J. Biol. Chem. 278 (17): 15123–7. doi: 10.1074/jbc.C300054200 . PMID   12584197.
• Ueberham U, Hessel A, Arendt T (2003). "Cyclin C expression is involved in the pathogenesis of Alzheimer's disease". Neurobiol. Aging. 24 (3): 427–35. doi:10.1016/S0197-4580(02)00132-X. PMID   12600719. S2CID   12604491.