CDC42EP4

CDC42EP4
Identifiers
Aliases	CDC42EP4 , BORG4, CEP4, KAIA1777, CDC42 effector protein 4
External IDs	OMIM: 605468 MGI: 1929760 HomoloGene: 8110 GeneCards: CDC42EP4
Gene location (Human)
Chr.	Chromosome 17 (human)
End	73,312,005 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	113,642,707 bp
RNA expression pattern
	Top expressed in
	optic nerve; ; olfactory bulb; ; left uterine tube; ; middle frontal gyrus; ; internal globus pallidus; ; corpus epididymis; ; external globus pallidus; ; nipple; ; caudate nucleus; ; pericardium;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; medullary collecting duct; ; spermatocyte; ; left lung lobe; ; utricle; ; cornea; ; stria vascularis; ; lip; ; condyle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; GTPase activator activity ; RNA binding ;
Cellular component	endomembrane system ; plasma membrane ; cytoskeleton ; microtubule cytoskeleton ; membrane ; actin cytoskeleton ; cytoplasm ; phagocytic vesicle ;
Biological process	positive regulation of actin filament polymerization ; positive regulation of pseudopodium assembly ; regulation of cell shape ; Rho protein signal transduction ; positive regulation of GTPase activity ; cellular response to interferon-gamma ;
	Sources:Amigo / QuickGO
Orthologs
	23580
	56699
	ENSG00000179604
	ENSMUSG00000041598
	Q9H3Q1
	Q9JM96
	NM_012121
	NM_001163346 ; NM_020006
	NP_036253
	NP_001156818 ; NP_064390
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene.^[5]^[6]^[7]

The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control.^[7]

Related Research Articles

The Rho family of GTPases is a family of small signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic kingdoms, including yeasts and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins play a role in organelle development, cytoskeletal dynamics, cell movement, and other common cellular functions.

Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene.

Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.

Transgelin is a protein that in humans is encoded by the TAGLN gene.

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.

Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene.

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.

Formin-binding protein 1-like is a protein that in humans is encoded by the FNBP1L gene.

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.

TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.

TBC1 domain family member 3E/3F is a protein that in humans is encoded by the TBC1D3F gene.

Disheveled-associated activator of morphogenesis 1 is a protein that in humans is encoded by the DAAM1 gene. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.

Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.

FYVE, RhoGEF and PH domain-containing protein 4 is a protein that in humans is encoded by the FGD4 gene.

SLIT-ROBO Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the SRGAP1 gene.

Rhophilin-1 is a protein that in humans is encoded by the RHPN1 gene.

Cofilin 2 (muscle) also known as CFL2 is a protein which in humans is encoded by the CFL2 gene.

The Rho GTPase activating protein 31 is encoded in humans by the ARHGAP31 gene. It is a Cdc42/Rac1 GTPase regulator.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000179604 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041598 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J Biol Chem. 276 (2): 875–83. doi: 10.1074/jbc.M007039200 . PMID 11035016.
↑ Joberty G, Perlungher RR, Macara IG (Feb 2000). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol Cell Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. PMC 84628 . PMID 10490598.
1 2 "Entrez Gene: CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4".

External links

Human CDC42EP4 genome location and CDC42EP4 gene details page in the UCSC Genome Browser .

Osada N, Kusuda J, Suzuki Y, et al. (2001). "Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue". J. Hum. Genet. 45 (6): 374–7. doi: 10.1007/s100380070012 . PMID 11185749.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Blackshaw S, Harpavat S, Trimarchi J, et al. (2006). "Genomic analysis of mouse retinal development". PLOS Biol. 2 (9): E247. doi:10.1371/journal.pbio.0020247. PMC 439783 . PMID 15226823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000179604 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041598 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11035016-5] Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J Biol Chem. 276 (2): 875–83. doi: 10.1074/jbc.M007039200 . PMID 11035016.

[pmid10490598-6] Joberty G, Perlungher RR, Macara IG (Feb 2000). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol Cell Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. PMC 84628 . PMID 10490598.

[entrez-7] 1 2 "Entrez Gene: CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4".

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CDC42EP4

Contents

Related Research Articles

References

External links

Further reading