CFAP157

Last updated
CFAP157
Identifiers
Aliases CFAP157 , C9orf117, cilia and flagella associated protein 157
External IDs MGI: 2447809 HomoloGene: 53056 GeneCards: CFAP157
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001012502

NM_025619

RefSeq (protein)

NP_001012520

NP_079895

Location (UCSC)n/a Chr 2: 32.67 – 32.67 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Cilia and flagella associated protein 157 (CFAP157) also known as chromosome 9 open reading frame 117 (c9orf117) is a protein that in humans is encoded by the CFAP157 gene.

Contents

CFAP157 gene is "specifically required during spermatogenesis for flagellum morphogenesis and sperm motility and may be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure," [4] according to UniProt.

Gene

Location

CFAP157 is located on chromosome 9, 9q34.11 in human from base pair 127,706,989 to base pair 127,716,002. [5]

Location of CFAP157 in chromosome 9 CFAP157-gene.png
Location of CFAP157 in chromosome 9

Features

The size of the gene is 9,013 bases, and the orientation is plus strand. [5] The gene holds 9 exons. [6]

mRNA

The most common variant of mRNAs of CFAP157 contains 1,722 base pairs. [6]

Expression

CFAP157 is expressed in many human body tissues such as cervix, lung, testis, and uterus. People who have uterine tumor are likely to have an expression in CFAP157. This gene is expressed in both adults and fetuses. [7]

Protein

There are 520 amino acids in CFAP157 in human. [8] The protein is glutamine extremely rich, and glycine poor. The protein is quite neutral with the isoelectric point at pH 7.4. [9] The average mass of the protein is estimated to be 60,531.748 Da, and the absorption coefficient is estimated to be 25,440 M−1 cm−1.

CFAP157 is primarily composed of α-helices, and there is no transmembrane helix. The protein structure making program called Phyre is used to create the predicted structure of CFAP157.

Predicted structure for CFAP157 made by Phyre CFAP157 predicted protein.png
Predicted structure for CFAP157 made by Phyre

Homology

There is no known paralog for CFAP157 in human. CFAP157 has numerous orthologs. The following table contains some of orthologs including human, common chimpanzee, rhesus macaque, cattle, dog, mouse, rat, tropical clawed frog, and zebra fish. [10]

SpeciesCommon NameAccession NumberSequence IdentitySequence Similarity
Homo sapiens HumanNP_001012520100%100%
Pan troglodytes Common chimpanzeeXP_00114308498.5%99.0%
Macaca mulatta Rhesus macaqueXP_00109528195.2%96.4%
Bos taurus CattleXP_00521347770.5%84.0%
Canis lupus familiaris DogXP_00562539271.5%80.9%
Mus musculus MouseNP_07989564.6%79.0%
Rattus norvegicus RatNP_00109433964.2%78.4%
Xenopus tropicalis Tropical clawed frogNP_00107277441.5%60.5%
Danio rerio ZebrafishNP_00110363834.0%54.9%

Interacting Proteins

P14335 (Kunjin virus strain MRM61C) is the virus that interacts with CFAP157 via two-hybrid screening. Kunjin virus is not as severe as other viruses, but this is a noticeable discovery because it is possible to exploit the interaction to develop new types of medicine. Researchers at the University of Queensland discovered a new medical use for the Kunjin virus in 2005, and the possible treatments include HIV/cancer vaccines. [11]

Related Research Articles

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<span class="mw-page-title-main">PRR29</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">TMEM176B</span>

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<span class="mw-page-title-main">C10orf67</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">TMCO4</span>

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<span class="mw-page-title-main">C6orf62</span>

Chromosome 6 open reading frame 62 (C6orf62), also known as X-trans-activated protein 12 (XTP12), is a gene that encodes a protein of the same name. The encoded protein is predicted to have a subcellular location within the cytosol.

<span class="mw-page-title-main">C16orf46</span> Human gene

Chromosome 16 open reading frame 46 is a protein of yet to be determined function in Homo sapiens. It is encoded by the C16orf46 gene with NCBI accession number of NM_001100873. It is a protein-coding gene with an overlapping locus.

<span class="mw-page-title-main">Transmembrane protein 44</span>

Transmembrane protein 44 is a protein that in humans is encoded by the TMEM44 gene.

<span class="mw-page-title-main">TMEM44</span>

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<span class="mw-page-title-main">C9orf25</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">FAM214B</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">THAP3</span> Protein in Humans

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<span class="mw-page-title-main">SCRN3</span>

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References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038987 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "CFAP157 - Cilia- and flagella-associated protein 157 - Homo sapiens (Human) - CFAP157 gene & protein". www.uniprot.org. Retrieved 2018-02-05.
  5. 1 2 Database, GeneCards Human Gene. "CFAP157 Gene - GeneCards | CF157 Protein | CF157 Antibody". www.genecards.org. Retrieved 2018-02-20.
  6. 1 2 "Homo sapiens cilia and flagella associated protein 157 (CFAP157), tran - Nucleotide - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-04-23.
  7. Group, Schuler. "EST Profile - Hs.652519". www.ncbi.nlm.nih.gov. Retrieved 2018-04-23.
  8. "cilia- and flagella-associated protein 157 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-02-20.
  9. "Prot pi | Bioinformatics Calculator". www.protpi.ch. Retrieved 2018-04-23.
  10. "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2018-04-23.
  11. "New medical uses for the Kunjin virus". News-Medical.net. 2005-04-12. Retrieved 2018-05-06.