CHMP1A

CHMP1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JQ9, 2YMB, 4A5X
Identifiers
Aliases	CHMP1A , CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A, charged multivesicular body protein 1A
External IDs	OMIM: 164010 MGI: 1920159 HomoloGene: 56240 GeneCards: CHMP1A
Gene location (Human)
Chr.	Chromosome 16 (human)
End	89,657,738 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	123,939,502 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; skin of abdomen; ; body of stomach; ; cingulate gyrus; ; stromal cell of endometrium; ; canal of the cervix; ; left uterine tube; ; right lobe of thyroid gland; ; right coronary artery; ; left lobe of thyroid gland;
	Top expressed in
	lip; ; esophagus; ; interventricular septum; ; duodenum; ; intestinal villus; ; large intestine; ; colon; ; ileum; ; visual cortex; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity ; protein domain specific binding ; zinc ion binding ; protein binding ; identical protein binding ; metallopeptidase activity ;
Cellular component	cytoplasm ; endosome ; membrane ; microtubule organizing center ; condensed nuclear chromosome ; early endosome ; endosome membrane ; extracellular exosome ; endomembrane system ; nucleus ; nuclear matrix ; ESCRT III complex ; multivesicular body ;
Biological process	carbon catabolite repression of transcription by glucose ; regulation of centrosome duplication ; regulation of transcription, DNA-templated ; viral budding via host ESCRT complex ; nucleus organization ; multivesicular body assembly ; regulation of mitotic spindle assembly ; transcription, DNA-templated ; cell division ; protein transport ; cell cycle ; septum digestion after cytokinesis ; mitotic metaphase plate congression ; negative regulation of transcription, DNA-templated ; vacuolar transport ; ESCRT III complex disassembly ; proteolysis ; mitotic chromosome condensation ; vesicle-mediated transport ; transport ; endosome transport via multivesicular body sorting pathway ; late endosome to vacuole transport ; negative regulation of cell cycle ; midbody abscission ;
	Sources:Amigo / QuickGO
Orthologs
	5119
	234852
	ENSG00000131165
	ENSMUSG00000000743
	Q9HD42
	Q921W0
	NM_001083314 ; NM_002768
	NM_145606
	NP_001076783 ; NP_002759
	NP_663581
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Charged multivesicular body protein 1a is a protein that in humans is encoded by the CHMP1A gene.^[5]^[6]^[7]

Function

This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein.^[7]

Interactions

CHMP1A has been shown to interact with VPS4A.^[5]

Related Research Articles

Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene.

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.

Charged multivesicular body protein 2b is a protein that in humans is encoded by the CHMP2B gene. It forms part of one of the endosomal sorting complexes required for transport (ESCRT) - specifically ESCRT-III - which are a series of complexes involved in cell membrane remodelling. CHMP2B forms long chains that spiral around the neck of a budding vesicle. Along with the other components of ESCRT-III, CHMP2B constricts the neck of the vesicle just before it is cleaved away from the membrane.

Ninein is a protein that in humans is encoded by the NIN gene. Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.

Vacuolar protein sorting-associated protein 4A is a protein that in humans is encoded by the VPS4A gene.

Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.

Nesprin-2 is a protein that in humans is encoded by the SYNE2 gene. The human SYNE2 gene consists of 116 exons and encodes nesprin-2, a member of the nuclear envelope (NE) spectrin-repeat (nesprin) family. Nesprins are modular proteins with a central extended spectrin-repeat (SR) rod domain and a C-terminal Klarsicht/ANC-1/Syne homology (KASH) transmembrane domain, which acts as a NE-targeting motif. Nesprin-2 (Nesp2) binds to cytoplasmic F-actin, tethering the nucleus to the cytoskeleton and maintaining the structural integrity of the nucleus.

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.

Charged multivesicular body protein 4b is a protein that in humans is encoded by the CHMP4B gene.

Charged multivesicular body protein 4a is a protein that in humans is encoded by the CHMP4A gene.

Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene.

Charged multivesicular body protein 6 is a protein that in humans is encoded by the CHMP6 gene.

Charged multivesicular body protein 2a is a protein that in humans is encoded by the CHMP2A gene.

It is a reference gene.

Charged multivesicular body protein 1b is a protein that in humans is encoded by the CHMP1B gene.

Charged multivesicular body protein 4c is a protein that in humans is encoded by the CHMP4C gene.

KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene.

Vacuolar protein-sorting-associated protein 25 is a protein that in humans is encoded by the VPS25 gene.

Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene.

CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene. This enzyme is a member of cyclin-dependent kinase protein family.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131165 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000743 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (July 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". Journal of Cell Science. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.
↑ Stauffer DR, Howard TL, Nyun T, Hollenberg SM (July 2001). "CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression". Journal of Cell Science. 114 (Pt 13): 2383–93. doi:10.1242/jcs.114.13.2383. PMID 11559747.
1 2 "Entrez Gene: PCOLN3 procollagen (type III) N-endopeptidase".

External links

Human CHMP1A genome location and CHMP1A gene details page in the UCSC Genome Browser .

Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi: 10.1093/dnares/1.5.223 . PMID 7584044.
Scott IC, Halila R, Jenkins JM, Mehan S, Apostolou S, Winqvist R, et al. (September 1996). "Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1)". Gene. 174 (1): 135–43. doi:10.1016/0378-1119(96)00510-0. PMID 8863740.
Yoshida H, Haze K, Yanagi H, Yura T, Mori K (December 1998). "Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors". The Journal of Biological Chemistry. 273 (50): 33741–9. doi: 10.1074/jbc.273.50.33741 . PMID 9837962.
Tong WY, Nagano-Fujii M, Hidajat R, Deng L, Takigawa Y, Hotta H (December 2002). "Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta" (PDF). Biochemical and Biophysical Research Communications. 299 (3): 366–72. doi:10.1016/S0006-291X(02)02638-4. PMID 12445808.
Strack B, Calistri A, Craig S, Popova E, Göttlinger HG (September 2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi: 10.1016/S0092-8674(03)00653-6 . PMID 14505569. S2CID 10733770.
von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E, et al. (September 2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi: 10.1016/S0092-8674(03)00714-1 . PMID 14505570. S2CID 16894972.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, Bieniasz PD, Yaravoy A (October 2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi: 10.1073/pnas.2133846100 . PMC 218772 . PMID 14519844.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
Row PE, Liu H, Hayes S, Welchman R, Charalabous P, Hofmann K, et al. (October 2007). "The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation" (PDF). The Journal of Biological Chemistry. 282 (42): 30929–37. doi: 10.1074/jbc.M704009200 . PMID 17711858. S2CID 28086824.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131165 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000743 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11559748-5] 1 2 Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (July 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". Journal of Cell Science. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.

[pmid11559747-6] Stauffer DR, Howard TL, Nyun T, Hollenberg SM (July 2001). "CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression". Journal of Cell Science. 114 (Pt 13): 2383–93. doi:10.1242/jcs.114.13.2383. PMID 11559747.

[entrez-7] 1 2 "Entrez Gene: PCOLN3 procollagen (type III) N-endopeptidase".

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