Cancer in cats

Last updated

Cancer in cats is the leading cause of death among cats. It is caused by uncontrolled cell growth, and affects a wide range of cell types and organs in the body. Feline cancer initially manifests as a lump or bump on any parts of the body. It rapidly grows in the affected cell, attaches itself to the tissue under the skin in that area, and, depending on the tumour, it can spread to other parts of the body. [1] Although cancer accounts for approximately 32% of deaths in cats over ten years old, it can be successfully treated if diagnosed early. [2]

Contents

While the causes of cancer in cats are unknown, feline leukemia virus is suspected to be a prime contributor. [2] Other factors suspected to increase rates of feline cancer include toxins from the environment, passive smoking, excessive grooming, or licking parts of the body that have been in contact with an environmental toxin. [2]

Cancer can be detected at an early stage by observing certain signs and symptoms. Common diagnostic methods include physical examination, x-rays, ultrasounds, cytology, blood tests, urine tests, and nuclear scans. Depending on the type of cancer and its level of progress, surgery, radiation, chemotherapy, or immunotherapy may be used to treat the cancer. Although research into causes and treatment of feline cancers has been slow, there have been advances in radiation therapy, as well as newer and improved chemotherapy procedures. [2]

Signs and symptoms

Cancer in cats can occur in any location or body system, [3] and most symptoms can be detected externally. [2] While each type of cancer has its own distinctive symptoms, most indicate their presence by the occurrence and the prolonged presence of any common symptom. [1] Some of the general symptoms of cancer in cats are: [3]

Lymphoma and lymphosarcoma

Lymphoma is the most common form of cancer in cats, is often associated with feline leukemia virus, and accounts for 25 percent of all cases. [3] Feline lymphoma usually strikes the digestive system, causing excessive vomiting and diarrhea. [4] Other common symptoms of lymphoma in cats include swollen lymph nodes, loss of appetite, weight loss, and difficulty breathing. [4]

Lymphoma and lymphosarcoma are common among cats with FeLV infections. It affects the intestines and other lymphatic tissues (commonly the abdominal organs). Cats with these cancers may be affected by a loss of appetite, weight loss, vomiting, diarrhea, bloody stool, and constipation.

Skin tumors

Skin tumors are less common in cats; although most cats are vulnerable, white cats are especially prone to this type of tumor. Skin tumors manifest as a visible lump on the skin, mostly affecting vision, smell, or eating. [5] Benign tumors take several years to develop and are more difficult to detect due to their freely movable nature. [6] The only indicator of benign tumors is self-trauma of a form called lick granuloma or "boredom sores", [7] which can be caused by excessive licking by the cat. [6] This is a sign that the cat is suffering from anxiety. [8] [9]

Mammary gland tumors

Mammary gland tumors are the third common type of cancer in older female cats, with the most common symptom manifesting as a lump in the breast tissue. [3] Domestic short-haired cats and Siamese appear to have a higher incident rates. [10] The tumor is typically firm and nodular, and adheres to the overlying skin. [11] Nipples may also appear to be red and swollen, oozing yellowish fluid. [11] Despite the overall poor prognosis of feline mammary carcinomas, in one study some cats survived >6 months, indicating that adjuvant treatment may be an option to consider in metastatic disease. [12]

Abdominal tumor

Abdominal tumor is among the rarest forms of cancer in cats, and most difficult to treat successfully before progressing to an advanced stage. [13] The main symptoms include abdominal enlargement, [3] vomiting (often with blood), weight loss due to poor digestion, and weakness. [13]

Types of tumor

Diagnosis

X-ray of FeLV-positive cat with lung cancer X-ray of FeLV-positive cat with lung cancer.jpg
X-ray of FeLV-positive cat with lung cancer

Diagnosing the type of cancer, by the analysis of the structure of the tumor and cancer cells, helps determine the best treatment. [15]

Treatment

Treatments of cancer in cats usually consists of diagnosis and observation of the tumor to determine its type and size, the development of a treatment plan, the associated goals on the part of the treatment methods, and the regular evaluation of the overall health of the pet.

Prevention

The prevention of feline cancer mainly depends on the cat's diet and lifestyle, as well as the detection of early signs and symptoms of cancer before it advances to a further stage. If cancer is detected at an earlier stage, it has a higher chance of being treated, thus improving the chance of survival. Taking cats for regular checkups to the veterinarian can help spot signs and symptoms of cancer early on.

Interaction with other cats

Interaction with other cats with strains or diseases related to FeLV can be a great risk factor for cats contracting FeLV themselves. Thus a main factor in prevention is keeping the affected cats in quarantine, separated from the unaffected cats. Stray cats, or indoor/outdoor cats have been shown to be at a greater risk for acquiring FeLV, since they have a greater chance of interacting with other cats. Domesticated cats that are kept indoors are the least vulnerable to susceptible diseases. [17]

Vaccines

Vaccines help the immune system fight off pathogens, which is another key to prevention. [17] A vaccine for feline leukemia virus was created in 1969. [16]

Spaying and neutering

Spaying and neutering holds many advantages for cats, including lowering the risk of developing cancer. Neutering male cats makes them less subject to testicular cancer, FeLV, and FIV. Spaying female cats lowers the risk of mammary, ovarian, and uterine cancer, as it prevents them from going into heat. Female cats should be spayed before their first heat, as each cycle of heat creates a greater risk of mammary cancer. Spaying a female cat requires the removal of the ovaries and uterus, which would eliminate their chances of developing cancer in these areas. [18]

Exposure to sun

The risk of skin cancer increases when a cat is exposed to direct sunlight for prolonged periods. White cats, or cats with white faces and ears, should not be allowed out on sunny days. Depending on climate and time zone, between the hours of 10:00 am to 4:00 pm, it is recommended to keep domesticated cats indoors, as the sun is at its highest peak between these times. Sun block is also available for cats, which can help prevent skin irritation, and a veterinarian should be contacted to find out which brands are appropriate and to use on cats. [19]

Exposure to second-hand smoke

Cats living in a smoker's household are three times more likely to develop lymphoma. [20] Compared to living in a smoke-free environment, cats exposed to passive smoking also have a greater chance of developing squamous cell carcinoma or mouth cancer. Cancer risk also arises from the cat's grooming habits. As cats lick themselves while they groom, they increase chances of taking in the carcinogens that gather on their fur, which then come into contact with their mucus membranes. [17]

Lifestyle

Providing a cat with the healthiest lifestyle possible is the key to prevention. Decreasing the amount of toxins, including household cleaning products, providing fresh and whole foods, clean and purified water, and reducing the amount of indoor pollution can help cats live a longer and healthier life. To lessen susceptibility to diseases, domesticated cats should be kept inside the household for most of their lives to reduce the risk of interacting with other cats that could be infected with diseases. [21]

Research

Small animals, like cats, experience faster rates of cancer development. As a result, they are good preclinical models for understanding processes like immortalization and its role in promoting cancerous tumors. [22]

See also

Related Research Articles

<span class="mw-page-title-main">Brain tumor</span> Neoplasm in the brain

A brain tumor occurs when abnormal cells form within the brain. There are two main types of tumors: malignant tumors and benign (non-cancerous) tumors. These can be further classified as primary tumors, which start within the brain, and secondary tumors, which most commonly have spread from tumors located outside the brain, known as brain metastasis tumors. All types of brain tumors may produce symptoms that vary depending on the size of the tumor and the part of the brain that is involved. Where symptoms exist, they may include headaches, seizures, problems with vision, vomiting and mental changes. Other symptoms may include difficulty walking, speaking, with sensations, or unconsciousness.

<span class="mw-page-title-main">Skin cancer</span> Medical condition involving uncontrolled growth of skin cells

Skin cancers are cancers that arise from the skin. They are due to the development of abnormal cells that have the ability to invade or spread to other parts of the body. There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous-cell skin cancer (SCC) and melanoma. The first two, along with a number of less common skin cancers, are known as nonmelanoma skin cancer (NMSC). Basal-cell cancer grows slowly and can damage the tissue around it but is unlikely to spread to distant areas or result in death. It often appears as a painless raised area of skin that may be shiny with small blood vessels running over it or may present as a raised area with an ulcer. Squamous-cell skin cancer is more likely to spread. It usually presents as a hard lump with a scaly top but may also form an ulcer. Melanomas are the most aggressive. Signs include a mole that has changed in size, shape, color, has irregular edges, has more than one color, is itchy or bleeds.

<span class="mw-page-title-main">Lymphoma</span> Hematologic cancer that affects lymphocytes

Lymphoma is a group of blood and lymph tumors that develop from lymphocytes. The name typically refers to just the cancerous versions rather than all such tumours. Signs and symptoms may include enlarged lymph nodes, fever, drenching sweats, unintended weight loss, itching, and constantly feeling tired. The enlarged lymph nodes are usually painless. The sweats are most common at night.

Neutering, from the Latin neuter, is the removal of a non-human animal's reproductive organ, either all of it or a considerably large part. The male-specific term is castration, while spaying is usually reserved for female animals. Colloquially, both terms are often referred to as fixing. In male horses, castrating is referred to as gelding. An animal that has not been neutered is sometimes referred to as entire or intact.

<i>Feline leukemia virus</i> Species of virus

Feline leukemia virus (FeLV) is a retrovirus that infects cats. FeLV can be transmitted from infected cats when the transfer of saliva or nasal secretions is involved. If not defeated by the animal's immune system, the virus weakens the cat's immune system, which can lead to diseases which can be lethal. Because FeLV is cat-to-cat contagious, FeLV+ cats should only live with other FeLV+ cats.

<span class="mw-page-title-main">Dog health</span> Health of dogs

The health of dogs is a well studied area in veterinary medicine.

<span class="mw-page-title-main">Lymphoma in animals</span> Type of cancer in animals

Lymphoma (lymphosarcoma) in animals is a type of cancer defined by a proliferation of malignant lymphocytes within solid organs such as the lymph nodes, bone marrow, liver and spleen. The disease also may occur in the eye, skin, and gastrointestinal tract.

<span class="mw-page-title-main">Mammary tumor</span>

A mammary tumor is a neoplasm originating in the mammary gland. It is a common finding in older female dogs and cats that are not spayed, but they are found in other animals as well. The mammary glands in dogs and cats are associated with their nipples and extend from the underside of the chest to the groin on both sides of the midline. There are many differences between mammary tumors in animals and breast cancer in humans, including tumor type, malignancy, and treatment options. The prevalence in dogs is about three times that of women. In dogs, mammary tumors are the second most common tumor over all and the most common tumor in female dogs with a reported incidence of 3.4%. Multiple studies have documented that spaying female dogs when young greatly decreases their risk of developing mammary neoplasia when aged. Compared with female dogs left intact, those spayed before puberty have 0.5% of the risk, those spayed after one estrous cycle have 8.0% of the risk, and dogs spayed after two estrous cycles have 26.0% of the risk of developing mammary neoplasia later in life. Overall, unspayed female dogs have a seven times greater risk of developing mammary neoplasia than do those that are spayed. While the benefit of spaying decreases with each estrous cycle, some benefit has been demonstrated in female dogs even up to 9 years of age. There is a much lower risk in male dogs and a risk in cats about half that of dogs.

<span class="mw-page-title-main">Anal sac adenocarcinoma</span> Malignant tumor found in dogs

An anal sac adenocarcinoma is an uncommon and aggressive malignant tumor found in dogs that arises from the apocrine glandular tissue of anal sac. The disease exists in cats as well, but is much less common in that species. They are the second most common cancerous cause of hypercalcaemia in dogs, following T-cell lymphoma.

<span class="mw-page-title-main">Small intestine cancer</span> Medical condition

Small intestine cancer starts when cells in the small intestine start to grow out of control. The small intestine is the largest part of the gastrointestinal tract, which processes food for energy and rids the body of solid waste. The small intestine is not as common as other cancers of the GI tract such as colon, rectal, stomach, and esophageal cancers in the United States. They account for fewer than 1 in 10 cancers in the GI tract, and fewer than 1 in 100 cancers overall.

<span class="mw-page-title-main">Nasopharyngeal carcinoma</span> Type of throat cancer; most common to occur in the nasopharynx

Nasopharyngeal carcinoma (NPC), or nasopharynx cancer, is the most common cancer originating in the nasopharynx, most commonly in the postero-lateral nasopharynx or pharyngeal recess, accounting for 50% of cases. NPC occurs in children and adults. NPC differs significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. It is vastly more common in certain regions of East Asia and Africa than elsewhere, with viral, dietary and genetic factors implicated in its causation. It is most common in males. It is a squamous cell carcinoma of an undifferentiated type. Squamous epithelial cells are a flat type of cell found in the skin and the membranes that line some body cavities. Undifferentiated cells are cells that do not have their mature features or functions.

Soft tissue sarcoma refers to a broad group of tumors that originate from connective tissues. They tend to have similar histologic appearance and biological behavior, and can be either benign or malignant. Soft tissue sarcomas can arise in any part of the pet's body but skin and subcutaneous tumors are the most commonly observed. Soft-tissue sarcomas comprise approximately 15% of all skin and subcutaneous tumors in dogs and approximately 7% of all skin and subcutaneous tumors in cats. The variety of different tumors that fall under the category of soft tissue sarcomas includes fibrosarcoma, hemangiopericytoma, liposarcoma, rhabdomyosarcoma, leiomyosarcoma, malignant fibrous histiocytoma, malignant nerve sheath tumors, myxosarcoma, myxofibrosarcoma, mesenchymoma, and spindle cell tumor.

<span class="mw-page-title-main">Cancer in dogs</span>

Cancer is the leading cause of death in dogs. It is estimated that 1 in 3 domestic dogs will develop cancer, which is the same incidence of cancer among humans. Dogs can develop a variety of cancers and most are very similar to those found in humans. Dogs can develop carcinomas of epithelial cells and organs, sarcomas of connective tissues and bones, and lymphomas or leukemias of the circulatory system. Selective breeding of dogs has led certain pure-bred breeds to be at high-risk for specific kinds of cancer.

The average age at which intestinal tumors are diagnosed ranges between 10–12 years for cats and 6 to 9 years for dogs. There are many different types of intestinal tumors, including lymphoma, adenocarcinoma, mast cell tumor, and leiomyosarcoma.

Many types of skin tumors, both benign (noncancerous) and malignant (cancerous), exist in cats and dogs. Approximately 20–40% of primary skin tumors are malignant in dogs and 50–65% are malignant in cats. Not all forms of skin cancer in cats and dogs are caused by sun exposure, but it can happen occasionally. On dogs, the nose and pads of the feet contain sensitive skin and no fur to protect from the sun. Also, cats and dogs with thin or light-colored coats are at a higher risk of sun damage over their entire bodies.

<span class="mw-page-title-main">Cat health</span> Health of domestic cats

The health of domestic cats is a well studied area in veterinary medicine.

<span class="mw-page-title-main">Hodgkin lymphoma</span> Type of blood and immune-system cancer

Hodgkin lymphoma (HL) is a type of lymphoma in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed–Sternberg cells are present in the patient's lymph nodes. The condition was named after the English physician Thomas Hodgkin, who first described it in 1832. Symptoms may include fever, night sweats, and weight loss. Often, nonpainful enlarged lymph nodes occur in the neck, under the arm, or in the groin. Those affected may feel tired or be itchy.

<span class="mw-page-title-main">Cancer signs and symptoms</span> Medical condition

Cancer symptoms are changes in the body caused by the presence of cancer. They are usually caused by the effect of a cancer on the part of the body where it is growing, although the disease can cause more general symptoms such as weight loss or tiredness. There are more than 100 different types of cancer with a wide range of signs and symptoms which can manifest in different ways.

<span class="mw-page-title-main">Extracranial germ cell tumor</span> Type of tumor

An extracranial germ cell tumor (EGCT) occurs in the abnormal growth of germ cells in the gonads and the areas other than the brain via tissue, lymphatic system, or circulatory system. The tumor can be benign or malignant (cancerous) by its growth rate. According to the National Cancer Institute and St. Jude Children's Research Hospital, the chance of children who are under 15 years old having EGCTs is 3%, in comparison to adolescents, a possibility of 14% with aged 15 to 19 can have EGCTs. There is no obvious cut point in between children and adolescents. However, common cut points in researches are 11 years old and 15 years old.

<span class="mw-page-title-main">Paranasal sinus and nasal cavity cancer</span> Medical condition

Paranasal sinus and nasal cavity cancer is a type of cancer that is caused by the appearance and spread of malignant cells into the paranasal sinus and nasal cavity. The cancer most commonly occurs in people between 50 and 70 years old, and occurs twice as often in males as in females. During early phases of the cancer, symptoms may include nasal obstruction and hyposmia, as well as other symptoms. More symptoms may develop as malignant cells further grow and spread into other nearby tissue such as the palate or orbital floor. X-rays of the head and MRI can aid in diagnosis of the cancer while tumor resection surgery, radiation therapy and chemotherapy can be used for treatment of the cancer.

References

  1. 1 2 "Feline Cancer Resources" . Retrieved 2012-03-22.
  2. 1 2 3 4 5 Eckstein, Sandy. "Cancer in Cats: Types, Symptoms, Prevention, and Treatment". WebMD. Retrieved 2012-03-22.Eldredge, Debra (2005). Cancer and Your Pet. Capital Books. ISBN   9781931868860 . Retrieved 2017-04-01 via Google Books.
  3. 1 2 3 4 5 Wells, Virginia. "Feline Cancer: What are the Warning Signs?". Intelligent Content Corp. Retrieved 2012-03-22.
  4. 1 2 "Lymphoma in Cats" (PDF). Southern California Veterinary Specialty Hospital. Archived from the original (PDF) on 2012-10-30. Retrieved 2012-03-22.
  5. "Skin Tumors in Cats: An Overview". Petwave. Archived from the original on 2012-06-10. Retrieved 2012-03-22.
  6. 1 2 "Skin Cancer (tumors) in Cats and Dogs". Pet Cancer Center. 2011-10-16. Retrieved 2012-03-22.
  7. Carlson, Delbert B.; Griffin, James M.; Carlson, Lisa (1995). Eldredge, Debra M.; Carlson, Delbert G.; Carlson, Liisa D.; Giffin, James M.; Adelman, Beth (eds.). Cat Owner's Home Veterinary Handbook. New York: Howell Book House. doi:10.1002/9781118269305. ISBN   9780470095300.
  8. Muller, George H.; Kirk, Robert Warren; Miller, William Howard; Griffin, Craig E. (2001). Muller & Kirk's Small Animal Dermatology. W.B. Saunders. ISBN   9780721676180.
  9. Ross, John (2001-03-04). "Curbing dog's anxiety may lick the medical problem". TribLive.com. Retrieved 2018-07-20.
  10. "Feline Mammary Tumors". vet.osu.edu. Veterinary Medical Center. Retrieved 2018-07-20.
  11. 1 2 "Mammary Gland (Breast) Cancer in Cats". Pet Cancer Center. 2011-10-16. Retrieved 2012-03-22.
  12. Petrucci, Gonçalo; Henriques, Joaquim; Gregório, Hugo; Vicente, Gonçalo; Prada, Justina; Pires, Isabel; Lobo, Luís; Medeiros, Rui; Queiroga, Felisbina (20 October 2020). "Metastatic feline mammary cancer: prognostic factors, outcome and comparison of different treatment modalities – a retrospective multicentre study". Journal of Feline Medicine and Surgery. 23 (6): 549–556. doi:10.1177/1098612X20964416. ISSN   1098-612X. PMID   33078692. S2CID   224811529.
  13. 1 2 "Stomach (Gastric) Cancer in Cats and Dogs". Pet Cancer Center. 2011-10-16. Retrieved 2012-03-22.
  14. 1 2 3 Blackwood, L.; Murphy, S.; Buracco, P.; De Vos, J. P.; De Fornel-Thibaud, P.; Hirschberger, J.; Kessler, M.; Pastor, J.; Ponce, F.; Savary-Bataille, K.; Argyle, D. J. (September 2012). "European consensus document on mast cell tumours in dogs and cats". Veterinary and Comparative Oncology. 10 (3): e1–e29. doi:10.1111/j.1476-5829.2012.00341.x. hdl: 2318/121456 . PMID   22882486. Open Access logo PLoS transparent.svg
  15. Pinney, C (2004). A Complete Home Veterinary Guide, pp. 663–683. McGraw Hill, United States.
  16. 1 2 Hardy, W. D. (1976). "Prevention of the contagious spread of feline leukaemia virus and the development of leukaemia in pet cats". Nature. 263 (5575): 326–328. Bibcode:1976Natur.263..326H. doi:10.1038/263326a0. PMID   183148. S2CID   4150645.
  17. 1 2 3 AScribe News. (2001). "Cats and Dogs Also Face Skin Cancer Danger From Sun." Chicago Tribune. Retrieved March 23.
  18. Syufy, Franny. (2012). "Care of a Pregnant Cat." Cats. Retrieved March 23.
  19. "Sunburn (Solar Dermatitis) in Cats – Symptoms, Treatments and How to Avoid Solar Dermatitis in Cats. Cat World. (2012). Retrieved March 23.
  20. Liz-Cat. (2010). "3 Ways to Help Your Cat Prevent Cancer Now." Natural Cat Care Blog. Retrieved March 23.
  21. Nelson, Brenda. (2008). How to Prevent Cancer in Cats. Knoji.
  22. Pang, Lisa; Argyle (February 2009). "Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology" (PDF). Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1792 (4): 380–391. doi:10.1016/j.bbadis.2009.02.010. hdl: 20.500.11820/ec487707-5340-4ada-a552-54a8004184bd . PMID   19254761. S2CID   26180427.