Cathepsin O

Last updated
CTSO
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CTSO , CTSO1, cathepsin O
External IDs OMIM: 600550 MGI: 2139628 HomoloGene: 1020 GeneCards: CTSO
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001334

NM_177662

RefSeq (protein)

NP_001325

NP_808330

Location (UCSC) Chr 4: 155.92 – 155.95 Mb Chr 3: 81.93 – 81.96 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cathepsin O is an enzyme that in humans is encoded by the CTSO gene. [5] [6]

Function

Cathepsin O is a cysteine protease and a member of the cathepsin family and papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases, and its proteolytic activity was abolished by an inhibitor of cysteine proteinase. [6]

Related Research Articles

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Cathepsin Z

Cathepsin Z, also called cathepsin X or cathepsin P, is a protein that in humans is encoded by the CTSZ gene. It is a member of the cysteine cathepsin protease family, which has 11 members. As one of the 11 cathepsins, cathepsin Z contains distinctive features from others. Cathepsin Z has been reported involved in cancer malignancy and inflammation.

Cathepsin L2

Cathepsin L2, also known as cathepsin V and encoded by the CTSV gene, is a human gene.

Cathepsin W

Cathepsin W is a protein that in humans is encoded by the CTSW gene.

SERPINB13

Serpin B13 is a protein that in humans is encoded by the SERPINB13 gene.

Cathepsin F

Cathepsin F is a protein that in humans is encoded by the CTSF gene.

CST9L

Cystatin-9-like is a protein that in humans is encoded by the CST9L gene.

TMPRSS6

Transmembrane protease, serine 6 is an enzyme that in humans is encoded by the TMPRSS6 gene.

CTRL (gene)

Chymotrypsin-like protease CTRL-1 is an enzyme that in humans is encoded by the CTRL gene.

CST11 Protein-coding gene in humans

Cystatin-11 is a protein that in humans is encoded by the CST11 gene.

CSTL1

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References

  1. 1 2 3 ENSG00000256043 GRCh38: Ensembl release 89: ENSG00000263238, ENSG00000256043 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028015 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Santamaría I, Pendás AM, Velasco G, López-Otín C (October 1998). "Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)". Genomics. 53 (2): 231–4. doi:10.1006/geno.1997.5180. PMID   9790772.
  6. 1 2 "Entrez Gene: cathepsin O".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.