Contactin

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Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. These proteins are attached to the neuronal membrane by a GPI-anchor. The subgroup consists of six members now referred to as contactin 1-6, [1] but historically they had different names as shown in the table below:

New nameOld name
Contactin 1 Contactin
Contactin 2 TAG-1
Contactin 3 BIG-1
Contactin 4 BIG-2
Contactin 5 NB-2
Contactin 6 NB-3

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Contactin 1

Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene.

Contactin 2

Contactin-2 is a protein that in humans is encoded by the CNTN2 gene.

NFASC

Neurofascin is a protein that in humans is encoded by the NFASC gene.

CNTNAP2

Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene. Since the most recent reference human genome GRCh38, CNTNAP2 is the longest gene in the human genome

Contactin 4

Contactin-4 is a protein that in humans is encoded by the CNTN4 gene.

Contactin 3

Contactin-3 is a protein that in humans is encoded by the CNTN3 gene.

Contactin 6

Contactin 6 is a protein in humans that is encoded by the CNTN6 gene.

CASPR

CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 gene. CASPR is a part of the neurexin family of proteins, hence its another name "Neurexin IV". CASPR is a membrane protein found in the neuronal membrane in the paranodal section of the axon[[]] in myelinated neurons, between the Nodes of Ranvier containing Na+ channels, and juxtaparanode, which contains K+ channels. During myelination, caspr associates with contactin in a cis complex, though its precise role in myelination is not yet understood.

Anti-neurofascin demyelinating diseases refers to health conditions engendered by auto-antibodies against neurofascins, which can produce both central and peripheral demyelination. Some cases of combined central and peripheral demyelination (CCPD) could be produced by them.

References

  1. Shimoda, Yasushi; Watanabe, Kazutada (1 January 2009). "Contactins". Cell Adh Migr. 3 (1): 64–70. PMC   2675151 . PMID   19262165.