DOM3Z

DXO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FQI, 3FQJ, 4J7L, 4J7M, 4J7N
Identifiers
Aliases	DXO , DOM3L, DOM3Z, NG6, RAI1, decapping exoribonuclease
External IDs	OMIM: 605996 MGI: 1890444 HomoloGene: 38061 GeneCards: DXO
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.33 Start 31,969,810 bp [1] End 31,972,290 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 35,055,995 bp [2] End 35,058,209 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary right lobe of liver Right adrenal gland left uterine tube left lobe of thyroid gland right lobe of thyroid gland prostate spleen body of stomach Top expressed in spermatocyte spermatid internal carotid artery external carotid artery yolk sac saccule adrenal gland otic placode lip proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding nuclease activity 5'-3' exonuclease activity exonuclease activity mRNA binding RNA pyrophosphohydrolase activity hydrolase activity magnesium ion binding metal ion binding RNA binding Cellular component plasma membrane nucleus cytosol Biological process nuclear mRNA surveillance mRNA catabolic process RNA destabilization nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1797 112403 Ensembl ENSG00000204348 ENSG00000236765 ENSG00000224313 ENSG00000206346 ENSG00000225682 ENSG00000234798 ENSMUSG00000040482 UniProt O77932 O70348 RefSeq (mRNA) NM_005510 NM_001371205 NM_001371206 NM_001163770 NM_033613 RefSeq (protein) NP_005501 NP_001358134 NP_001358135 NP_001157242 NP_291091 Location (UCSC) Chr 6: 31.97 – 31.97 Mb Chr 17: 35.06 – 35.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Dom3Z is a protein that in humans is encoded by the DOM3Z gene. ^{[5] [6]}

This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. ^[6]

References

1. ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 GRCh38: Ensembl release 89: ENSG00000204348, ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040482 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yang Z, Shen L, Dangel AW, Wu LC, Yu CY (Dec 1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID   9799600.
6. "Entrez Gene: DOM3Z dom-3 homolog Z (C. elegans)".

Further reading

• Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213–30. doi:10.1159/000019075. PMID   10072631. S2CID   25061446.
• Yang Z, Yu CY (2000). "Organizations and gene duplications of the human and mouse MHC complement gene clusters". Exp. Clin. Immunogenet. 17 (1): 1–17. doi:10.1159/000019119. PMID   10686478. S2CID   45164668.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi: 10.1038/nature02055 . PMID   14574404.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC   403804 . PMID   14656967.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID   14667819.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.