Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the major progestogen in the body. Progesterone has a variety of important functions in the body. It is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid.
Dioscorea alata, also known as purple yam, ube, or greater yam, among many other names, is a species of yam. The tubers are usually a vivid violet-purple to bright lavender in color, but some range in color from cream to plain white. It is sometimes confused with taro and the Okinawa sweet potato beniimo (紅芋), however D. alata is also grown in Okinawa. With its origins in the Asian tropics, D. alata has been known to humans since ancient times.
Dioscorea is a genus of over 600 species of flowering plants in the family Dioscoreaceae, native throughout the tropical and warm temperate regions of the world. The vast majority of the species are tropical, with only a few species extending into temperate climates. It was named by the monk Charles Plumier after the ancient Greek physician and botanist Dioscorides.
Dioscorea villosa is a species of twining tuberous vine which is native to eastern North America. It is commonly known as wild yam, colic root, rheumatism root, devil's bones, and fourleaf yam. It is common and widespread in a range stretching from Texas and Florida north to Minnesota, Ontario and Massachusetts.
Yam is the common name for some plant species in the genus Dioscorea that form edible tubers. The tubers of some other species in the genus, such as D. communis, are toxic. Yams are perennial herbaceous vines cultivated for the consumption of their starchy tubers in many temperate and tropical regions, especially in West Africa, South America and the Caribbean, Asia, and Oceania. The tubers themselves, also called "yams", come in a variety of forms owing to numerous cultivars and related species.
Dioscorea polystachya or Chinese yam, also called cinnamon-vine, is a species of flowering plant in the yam family. It is sometimes called Chinese potato or by its Korean name ma. It is also called huaishan in Mandarin and waisan in Cantonese.
Dioscorea bulbifera is a species of true yam in the yam family, Dioscoreaceae. It is native to Africa, Asia and northern Australia. It is widely cultivated and has become naturalized in many regions.
Diosgenin, a phytosteroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam species, such as the Kokoro. The sugar-free (aglycone) product of such hydrolysis, diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone, and other steroid products.
Dioscorea mexicana, Mexican yam or cabeza de negro is a species of yam in the genus Dioscorea.
The Marker degradation is a three-step synthetic route in steroid chemistry developed by American chemist Russell Earl Marker in 1938–1940. It is used for the production of cortisone and mammalian sex hormones from plant steroids, and established Mexico as a world center for steroid production in the years immediately after World War II. The discovery of the Marker degradation allowed the production of substantial quantities of steroid hormones for the first time, and was fundamental in the development of the contraceptive pill and corticosteroid anti-inflammatory drugs. In 1999, the American Chemical Society and the Sociedad Química de México named the route as an International Historic Chemical Landmark.
Dioscorea esculenta, commonly known as the lesser yam, is a yam species native to Island Southeast Asia and introduced to Near Oceania and East Africa by early Austronesian voyagers. It is grown for their edible tubers, though it has smaller tubers than the more widely-cultivated Dioscorea alata and is usually spiny.
Conessine is a steroidal alkaloid found in a number of plant species from the family Apocynaceae, including Holarrhena floribunda, Holarrhena antidysenterica and Funtumia elastica. It acts as a histamine antagonist, selective for the H3 subtype (with an affinity of pKi = 8.27; Ki = ~5 nM). It was also found to have long CNS clearance times, high blood–brain barrier penetration and high affinity for the adrenergic receptors.
Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla, a family of climbing plants found in subtropical regions. It was one of the first sapogenins to be identified, and the first spirostan steroid to be identified as such. The identification of the spirostan structure, with its ketone spiro acetal functionality, was fundamental in the development of the Marker degradation, which allowed the industrial production of progesterone and other sex hormones from plant steroids.
Nigeria is by far the world’s largest producer of yams, accounting for over 70–76 percent of the world production. According to the Food and Agriculture Organization report, in 1985, Nigeria produced 18.3 million tonnes of yam from 1.5 million hectares, representing 73.8 percent of total yam production in Africa. According to 2008 figures, yam production in Nigeria has nearly doubled since 1985, with Nigeria producing 35.017 million metric tonnes with value equivalent of US$5.654 billion. In perspective, the world's second and third largest producers of yams, Côte d'Ivoire and Ghana, only produced 6.9 and 4.8 million tonnes of yams in 2008 respectively. According to the International Institute of Tropical Agriculture, Nigeria accounted for about 70 percent of the world production amounting to 17 million tonnes from land area 2,837,000 hectares under yam cultivation.
Dioscorea composita, or barbasco, is a species of yam in the genus Dioscorea, native to Mexico. It is notable for its role in the production of diosgenin, which is a precursor for the synthesis of hormones such as progesterone. Russell Marker developed the extraction and manufacture of hormones from D. mexicana at Syntex, starting the trade of D. composita in Mexico. Marker also discovered that the composita variety had a much higher content of diosgenin than the mexicana variety, and therefore it came to replace the latter in the production of synthetic hormones.
The Mexican barbasco trade was the trade of the diosgenin-rich yam species Dioscorea mexicana, Dioscorea floribunda and Dioscorea composita which emerged in Mexico in the 1950s as part of the Mexican steroid industry. The trade consisted in Mexican campesinos harvesting the root in the jungle, selling it to middlemen who brought it to processing plants where the root was fermented and the diosgenin extracted and sold to pharmaceutical companies such as Syntex who used it to produce synthetic hormones.
Dioscorea zingiberensis, is a species of yam, a tuberous root vegetable. It has been cultivated in China for the production of diosgenin, an important pharmaceutical intermediate for the synthesis of steroid hormones. The rhizomes also produces steroidal saponins (TSS) as part of a treatment for cardiovascular disease.
Trillium govanianum is a high-value medicinal herb belonging to the family Melanthiaceae and is mainly distributed from Pakistan to Bhutan between the altitudinal ranges of 2500–4000 metres above sea level across the Himalayan region. It is a native species of the Himalayas, usually preferring shady areas in the forest for its profuse growth.
Sushil Kumar was an Indian geneticist and academic, known for his Plant and microbial genetical genomics, especially the studies on Escherichia coli and Lambda phage as well as on the mutants of Rhizobium. He was a former director of the Central Institute of Medicinal and Aromatic Plants of the Council of Scientific and Industrial Research and an elected fellow of the Indian National Science Academy, National Academy of Agricultural Sciences, National Academy of Sciences, India, and Indian Academy of Sciences. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1981, for his contributions to biological sciences.
Dioscorea deltoidea, the Nepal yam, is a species of flowering plant in the family Dioscoreaceae. Its native range is the Himalayas through to south-central China and mainland Southeast Asia. Its tubers contain diosgenin and are harvested by local peoples as a treatment for a variety of conditions, including gastrointestinal disorders and intestinal worms. Tubers are also eaten after boiling, washing, and baking. It grows in forests and humus-rich soils.
