EDC3

EDC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VC8, 2WAX, 2WAY, 3D3J, 3D3K
Identifiers
Aliases	EDC3 , LSM16, YJDC, YJEFN2, MRT50, enhancer of mRNA decapping 3, hYjeF_N2-15q23
External IDs	OMIM: 609842 MGI: 2142951 HomoloGene: 11827 GeneCards: EDC3
Gene location (Human)
Chr.	Chromosome 15 (human)
End	74,696,292 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	57,659,782 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; islet of Langerhans; ; right lobe of thyroid gland; ; rectum; ; left lobe of thyroid gland; ; monocyte; ; gastrocnemius muscle; ; popliteal artery; ; thymus;
	Top expressed in
	primitive streak; ; hand; ; otolith organ; ; yolk sac; ; utricle; ; external carotid artery; ; trigeminal ganglion; ; internal carotid artery; ; fossa; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; phosphodiesterase decapping endonuclease activity ; identical protein binding ; RNA binding ; mRNA binding ;
Cellular component	cytoplasm ; cytosol ; membrane ; P-body ; cytoplasmic ribonucleoprotein granule ;
Biological process	P-body assembly ; exonucleolytic catabolism of deadenylated mRNA ; RNA phosphodiester bond hydrolysis, endonucleolytic ; deadenylation-independent decapping of nuclear-transcribed mRNA ;
	Sources:Amigo / QuickGO
Orthologs
	80153
	353190
	ENSG00000179151
	ENSMUSG00000038957
	Q96F86
	Q8K2D3
	NM_001142443 ; NM_001142444 ; NM_025083 ; NM_001351378 ; NM_001351379
	NM_153799
	NP_001135915 ; NP_001135916 ; NP_079359 ; NP_001338307 ; NP_001338308
	NP_722494
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 29, 2024

Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.^[5]^[6]^[7]

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000179151 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038957 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Albrecht M, Lengauer T (Jun 2004). "Novel Sm-like proteins with long C-terminal tails and associated methyltransferases". FEBS Lett. 569 (1–3): 18–26. doi: 10.1016/j.febslet.2004.03.126 . PMID 15225602.
↑ Rudolph C, Sigruener A, Hartmann A, Orso E, Bals-Pratsch M, Gronwald W, Seifert B, Kalbitzer HR, Verdorfer I, Luetjens CM, Ortmann O, Bornstein SR, Schmitz G (May 2007). "ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis". Horm Metab Res. 39 (5): 322–35. doi:10.1055/s-2007-977699. PMID 17533573. S2CID 10679128.
1 2 "Entrez Gene: EDC3 enhancer of mRNA decapping 3 homolog (S. cerevisiae)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC 524842 . PMID 15498874.
Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (2006). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping". Mol. Cell. 20 (6): 905–15. doi: 10.1016/j.molcel.2005.10.031 . PMID 16364915.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E, Weichenrieder O (2007). "A Divergent Sm Fold in EDC3 Proteins Mediates DCP1 Binding and P-Body Targeting". Mol. Cell. Biol. 27 (24): 8600–11. doi:10.1128/MCB.01506-07. PMC 2169425 . PMID 17923697.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000179151 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038957 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15225602-5] Albrecht M, Lengauer T (Jun 2004). "Novel Sm-like proteins with long C-terminal tails and associated methyltransferases". FEBS Lett. 569 (1–3): 18–26. doi: 10.1016/j.febslet.2004.03.126 . PMID 15225602.

[pmid17533573-6] Rudolph C, Sigruener A, Hartmann A, Orso E, Bals-Pratsch M, Gronwald W, Seifert B, Kalbitzer HR, Verdorfer I, Luetjens CM, Ortmann O, Bornstein SR, Schmitz G (May 2007). "ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis". Horm Metab Res. 39 (5): 322–35. doi:10.1055/s-2007-977699. PMID 17533573. S2CID 10679128.

[entrez-7] 1 2 "Entrez Gene: EDC3 enhancer of mRNA decapping 3 homolog (S. cerevisiae)".

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EDC3

Related Research Articles

References

Further reading