FTSJ3

FTSJ3
Identifiers
Aliases	FTSJ3 , EPCS3, SPB1, FtsJ homolog 3, FtsJ RNA methyltransferase homolog 3, FtsJ RNA 2'-O-methyltransferase 3
External IDs	OMIM: 618411 MGI: 1860295 HomoloGene: 5451 GeneCards: FTSJ3
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q23.3 Start 63,819,433 bp [1] End 63,830,012 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 E1|11 68.89 cM Start 106,139,968 bp [2] End 106,146,905 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium gastric mucosa Right adrenal gland right lobe of thyroid gland canal of the cervix left lobe of thyroid gland left uterine tube spleen body of stomach Top expressed in yolk sac morula primitive streak spermatocyte maxillary prominence abdominal wall neural tube secondary oocyte somite lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity rRNA methyltransferase activity protein binding RNA binding rRNA (uridine-2'-O-)-methyltransferase activity rRNA (guanine) methyltransferase activity Cellular component nucleus nucleolus preribosome, large subunit precursor preribosome, small subunit precursor Biological process rRNA processing methylation RNA methylation ribosome biogenesis maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA methylation enzyme-directed rRNA 2'-O-methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117246 56095 Ensembl ENSG00000108592 ENSMUSG00000020706 UniProt Q8IY81 Q9DBE9 RefSeq (mRNA) NM_017647 NM_025310 RefSeq (protein) NP_060117 NP_079586 Location (UCSC) Chr 17: 63.82 – 63.83 Mb Chr 11: 106.14 – 106.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Putative rRNA methyltransferase 3 is an enzyme that in humans is encoded by the FTSJ3 gene. ^[5]

Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000108592 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020706 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FTSJ3 FtsJ homolog 3 (E. coli)".

Further reading

• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.