GRB14

GRB14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AUG, 2AUH, 4K81
Identifiers
Aliases	GRB14 , growth factor receptor bound protein 14
External IDs	OMIM: 601524 MGI: 1355324 HomoloGene: 3303 GeneCards: GRB14
Gene location (Human)
Chr.	Chromosome 2 (human)
End	164,621,482 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	64,855,331 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; corpus epididymis; ; Right adrenal gland; ; body of tongue; ; renal medulla; ; body of pancreas; ; kidney; ; kidney tubule; ; Brodmann area 23; ; thoracic diaphragm;
	Top expressed in
	interventricular septum; ; myocardium of ventricle; ; cardiac muscles; ; right ventricle; ; trigeminal ganglion; ; atrium; ; digastric muscle; ; soleus muscle; ; sciatic nerve; ; masseter muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	receptor tyrosine kinase binding ; identical protein binding ; protein homodimerization activity ;
Cellular component	cytoplasm ; cytosol ; endosome ; plasma membrane ; endosome membrane ; intracellular membrane-bounded organelle ; membrane ;
Biological process	positive regulation of signal transduction ; leukocyte migration ; signal transduction ; negative regulation of insulin receptor signaling pathway ; insulin receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	2888
	50915
	ENSG00000115290
	ENSMUSG00000026888
	Q14449
	Q9JLM9
	NM_001303422 ; NM_004490
	NM_016719
	NP_001290351 ; NP_004481
	NP_057928
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.^[5]^[6]

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.^[6]

Interactions

GRB14 has been shown to interact with Epidermal growth factor receptor,^[7] Fibroblast growth factor receptor 1 ^[8] and TNKS2.^[9]

Related Research Articles

Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene.

<span class="mw-page-title-main">GRB2</span> Protein-coding gene in the species Homo sapiens

Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.

<span class="mw-page-title-main">PTPN11</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.

Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family, the IL-4 receptor family, the gp130 receptor family. It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.

Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.

Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.

AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.

Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.

Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.

Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene.

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115290 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026888 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Baker E, Sutherland GR, Sutherland RL, Daly RJ (February 1997). "Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization". Genomics. 36 (1): 218–220. doi:10.1006/geno.1996.0453. PMID 8812444.
1 2 "Entrez Gene: GRB14 growth factor receptor-bound protein 14".
↑ Daly, R J; Sanderson G M; Janes P W; Sutherland R L (May 1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. UNITED STATES. 271 (21): 12502–12510. doi: 10.1074/jbc.271.21.12502 . ISSN 0021-9258. PMID 8647858.
↑ Reilly, J F; Mickey G; Maher P A (March 2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. UNITED STATES. 275 (11): 7771–7778. doi: 10.1074/jbc.275.11.7771 . ISSN 0021-9258. PMID 10713090.
↑ Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. United States. 276 (20): 17172–17180. doi: 10.1074/jbc.M009756200 . ISSN 0021-9258. PMID 11278563.

Han DC, Shen TL, Guan JL (2001). "The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions". Oncogene. 20 (44): 6315–6321. doi: 10.1038/sj.onc.1204775 . PMID 11607834.
Daly RJ, Sanderson GM, Janes PW, Sutherland RL (1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. 271 (21): 12502–12510. doi: 10.1074/jbc.271.21.12502 . PMID 8647858.
Kasus-Jacobi A, Perdereau D, Auzan C, et al. (1998). "Identification of the rat adapter Grb14 as an inhibitor of insulin actions". J. Biol. Chem. 273 (40): 26026–26035. doi: 10.1074/jbc.273.40.26026 . PMID 9748281.
Jones N, Master Z, Jones J, et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration". J. Biol. Chem. 274 (43): 30896–30905. doi: 10.1074/jbc.274.43.30896 . PMID 10521483.
Reilly JF, Mickey G, Maher PA (2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. 275 (11): 7771–7778. doi: 10.1074/jbc.275.11.7771 . PMID 10713090.
Hemming R, Agatep R, Badiani K, et al. (2001). "Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins". Biochem. Cell Biol. 79 (1): 21–32. doi:10.1139/bcb-79-1-21. PMID 11235915.
Lyons RJ, Deane R, Lynch DK, et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. 276 (20): 17172–17180. doi: 10.1074/jbc.M009756200 . PMID 11278563.
Béréziat V, Kasus-Jacobi A, Perdereau D, et al. (2002). "Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14". J. Biol. Chem. 277 (7): 4845–4852. doi: 10.1074/jbc.M106574200 . PMID 11726652.
Cariou B, Perdereau D, Cailliau K, et al. (2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta". Mol. Cell. Biol. 22 (20): 6959–6970. doi:10.1128/MCB.22.20.6959-6970.2002. PMC 139806 . PMID 12242277.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
King CC, Newton AC (2004). "The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1". J. Biol. Chem. 279 (36): 37518–37527. doi: 10.1074/jbc.M405340200 . PMID 15210700.
Scharf PJ, Witney J, Daly R, Lyons BA (2005). "Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain". Protein Sci. 13 (9): 2541–2546. doi:10.1110/ps.04884704. PMC 2280013 . PMID 15322292.
Kairouz R, Parmar J, Lyons RJ, et al. (2005). "Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells". J. Cell. Physiol. 203 (1): 85–93. doi:10.1002/jcp.20199. PMID 15372466. S2CID 24949216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Depetris RS, Hu J, Gimpelevich I, et al. (2006). "Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14". Mol. Cell. 20 (2): 325–333. doi:10.1016/j.molcel.2005.09.001. PMC 4526137 . PMID 16246733.
Park JJ, Berggren JR, Hulver MW, et al. (2006). "GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle". Physiol. Genomics. 27 (2): 114–121. doi:10.1152/physiolgenomics.00045.2006. PMID 16849634.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115290 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026888 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812444-5] Baker E, Sutherland GR, Sutherland RL, Daly RJ (February 1997). "Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization". Genomics. 36 (1): 218–220. doi:10.1006/geno.1996.0453. PMID 8812444.

[entrez-6] 1 2 "Entrez Gene: GRB14 growth factor receptor-bound protein 14".

[pmid8647858-7] Daly, R J; Sanderson G M; Janes P W; Sutherland R L (May 1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. UNITED STATES. 271 (21): 12502–12510. doi: 10.1074/jbc.271.21.12502 . ISSN 0021-9258. PMID 8647858.

[pmid10713090-8] Reilly, J F; Mickey G; Maher P A (March 2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. UNITED STATES. 275 (11): 7771–7778. doi: 10.1074/jbc.275.11.7771 . ISSN 0021-9258. PMID 10713090.

[pmid11278563-9] Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. United States. 276 (20): 17172–17180. doi: 10.1074/jbc.M009756200 . ISSN 0021-9258. PMID 11278563.

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GRB14

Contents

Interactions

Related Research Articles

References

Further reading