HEMGN

HEMGN
Identifiers
Aliases	HEMGN , CT155, EDAG, EDAG-1, NDR, hemogen
External IDs	OMIM: 610715 MGI: 2136910 HomoloGene: 14223 GeneCards: HEMGN
Gene location (Human)
Chr.	Chromosome 9 (human)
End	97,944,856 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	46,413,506 bp
RNA expression pattern
	Top expressed in
	cancellous bone; ; sperm; ; bone marrow; ; bone marrow cells; ; monocyte; ; blood; ; ganglionic eminence; ; placenta; ; thymus; ; amniotic fluid;
	Top expressed in
	body of femur; ; spleen; ; right lobe of liver; ; blood; ; bone marrow; ; yolk sac; ; abdominal wall; ; red pulp; ; spermatid; ; sexually immature organism;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	nucleus ; nucleoplasm ;
Biological process	multicellular organism development ; cell differentiation ; regulation of osteoblast differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	55363
	93966
	ENSG00000136929
	ENSMUSG00000028332
	Q9BXL5
	Q9ERZ0
	NM_018437 ; NM_197978
	NM_053149
	NP_060907 ; NP_932095
	NP_444379
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Hemogen is a protein that in humans is encoded by the HEMGN gene.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136929 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028332 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: HEMGN hemogen".

Yang LV, Nicholson RH, Kaplan J, et al. (2001). "Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms". Mech. Dev. 104 (1–2): 105–11. doi:10.1016/S0925-4773(01)00376-8. PMID 11404085. S2CID 2968450.
Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073 . PMID 11483580.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Yang LV, Heng HH, Wan J, et al. (2004). "Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis". Dev. Dyn. 228 (4): 606–16. doi:10.1002/dvdy.10399. PMID 14648837. S2CID 26030697.
Liu CC, Chou YL, Ch'ang LY (2004). "Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells". J. Biomed. Sci. 11 (1): 104–16. doi:10.1159/000075293. PMID 14730214. S2CID 202650770.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Li CY, Zhan YQ, Xu CW, et al. (2005). "EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B". Cell Death Differ. 11 (12): 1299–308. doi: 10.1038/sj.cdd.4401490 . PMID 15332117.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
An LL, Li G, Wu KF, et al. (2005). "High expression of EDAG and its significance in AML". Leukemia. 19 (8): 1499–502. doi:10.1038/sj.leu.2403808. PMID 15920494.
Yang LV, Wan J, Ge Y, et al. (2006). "The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells". Leukemia. 20 (3): 417–25. doi:10.1038/sj.leu.2404105. PMID 16437149.
Ling B, Zhou Y, Feng D, et al. (2007). "Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells". Oncol. Rep. 18 (3): 659–64. doi: 10.3892/or.18.3.659 . PMID 17671716.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136929 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028332 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HEMGN hemogen".

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[5]

HEMGN

Related Research Articles

References

Further reading