HS3ST3B1

Last updated
HS3ST3B1
Protein HS3ST3B1 PDB 1t8t.png
Identifiers
Aliases HS3ST3B1 , 30ST3B1, 3OST3B1, 3-OST-3B, h3-OST-3B, heparan sulfate-glucosamine 3-sulfotransferase 3B1
External IDs OMIM: 604058 MGI: 1333853 HomoloGene: 88576 GeneCards: HS3ST3B1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006041

NM_018805

RefSeq (protein)

NP_006032

NP_061275

Location (UCSC) Chr 17: 14.3 – 14.35 Mb Chr 11: 63.78 – 63.81 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene. [5] [6] Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [6]

Related Research Articles

<span class="mw-page-title-main">Heparan sulfate</span> Macromolecule

Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. In this form, HS binds to a variety of protein ligands, including Wnt, and regulates a wide range of biological activities, including developmental processes, angiogenesis, blood coagulation, abolishing detachment activity by GrB, and tumour metastasis. HS has also been shown to serve as cellular receptor for a number of viruses, including the respiratory syncytial virus. One study suggests that cellular heparan sulfate has a role in SARS-CoV-2 Infection, particularly when the virus attaches with ACE2.

In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 1 is an enzyme that catalyzes the chemical reaction

In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 2 is an enzyme that catalyzes the chemical reaction

In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 3 is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">SULT2B1</span> Protein-coding gene in the species Homo sapiens

Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene.

<span class="mw-page-title-main">PAPSS1</span> Protein-coding gene in the species Homo sapiens

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 is an enzyme that in humans is encoded by the PAPSS1 gene.

<span class="mw-page-title-main">CHST4</span> Protein-coding gene in the species Homo sapiens

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.

<span class="mw-page-title-main">NDST1</span> Enzyme

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.

<span class="mw-page-title-main">GALNAC4S-6ST</span> Protein-coding gene in the species Homo sapiens

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

<span class="mw-page-title-main">GAL3ST2</span> Protein-coding gene in the species Homo sapiens

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.

<span class="mw-page-title-main">HS3ST3A1</span> Protein-coding gene in the species Homo sapiens

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.

<span class="mw-page-title-main">HS3ST1</span> Protein-coding gene in the species Homo sapiens

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.

<span class="mw-page-title-main">NDST2</span> Enzyme

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 is an enzyme that in humans is encoded by the NDST2 gene.

<span class="mw-page-title-main">HS2ST1</span> Enzyme

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.

<span class="mw-page-title-main">CHST7</span> Protein-coding gene in humans

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.

<span class="mw-page-title-main">GAL3ST3</span> Protein-coding gene in the species Homo sapiens

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.

<span class="mw-page-title-main">NDST3</span> Enzyme

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene. It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H+ + N-sulfo-α-D-glucosaminyl-[heparan sulfate](n)

<span class="mw-page-title-main">CHST10</span> Protein-coding gene in the species Homo sapiens

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.

<span class="mw-page-title-main">HS3ST2</span> Protein-coding gene in the species Homo sapiens

Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.

<span class="mw-page-title-main">Carbohydrate sulfotransferase</span> Class of enzymes which transfer an –SO3 group to glycoproteins and lipids

In biochemistry, carbohydrate sulfotransferases are enzymes within the class of sulfotransferases which catalyze the transfer of the sulfate functional group to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular communication. Carbohydrates are suitable for such a wide variety of functions due to the diversity in structure generated from monosaccharide composition, glycosidic linkage positions, chain branching, and covalent modification. Possible covalent modifications include acetylation, methylation, phosphorylation, and sulfation. Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters. These sulfate esters are only located extracellularly, whether through excretion into the extracellular matrix (ECM) or by presentation on the cell surface. As extracellular compounds, sulfated carbohydrates are mediators of intercellular communication, cellular adhesion, and ECM maintenance.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000125430 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070407 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (Mar 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". J Biol Chem. 274 (8): 5170–84. doi: 10.1074/jbc.274.8.5170 . PMID   9988767.
  6. 1 2 "Entrez Gene: HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1".

Further reading