Hanadi Sleiman

Last updated
Hanadi Sleiman

FRS
Born
Hanadi Farouk Sleiman
Alma mater Stanford University
Scientific career
Institutions McGill University
French National Centre for Scientific Research
Thesis "Photochemical" azo metathesis by tungsten carbenes. Generation of low valent tungsten nitrenes  (1990)
Academic advisors Jean-Marie Lehn

Hanadi Farouk Sleiman FRS is a Canadian chemist who is Canada Research Chair in DNA Nanoscience at McGill University. Her research makes use of DNA as a template for nanomaterials. She was awarded the Natural Sciences and Engineering Research Council Polanyi Award in 2021.

Contents

Early life and education

Sleiman was an undergraduate and doctoral researcher at Stanford University, where she studied tungsten nitrenes. At Stanford, she attended a lecture by Jean-Marie Lehn who discussed supramolecular chemistry. After earning her doctorate, she moved to the Louis Pasteur University as a French National Centre for Scientific Research (CNRS) Fellow, where she worked alongside Jean-Marie Lehn.

Research and career

In 1999, Sleiman joined the faculty at McGill University, where she started using DNA to assemble nanomaterials. In particular she is interested in DNA structures that can target cancer cells and make them respond to chemotherapy. [1] She has designed tuneable DNA cages and nanotubes that can encapsulate and selectively release pharmaceuticals when they encounter a biological stimulus. [2] These non toxic cages can facilitate personalised drug delivery, that is, healthcare that is based on a person's genetics, environment or lifestyle. [3] They can rapidly enter mammalian cells, turning on and off gene expression and modulating their behaviour. [2] Sleiman has proposed that nucleic acids will enable precision oncology. [4] [5]

Sleiman has shown that it is possible to chemically imprint polymer particles with DNA strands for soft robotics. [6] She joined the Society for the Advancement of Science and Technology in the Arab World in 2011. [7]

Awards and honours

Selected publications

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References

  1. Interview with Hanadi Sleiman , retrieved 2023-03-03
  2. 1 2 "DNA Nanostructures for Cellular Delivery of TherapeuticsDr. Hanadi Sleiman (McGill) – Concordia University". www.concordia.ca. Retrieved 2023-03-03.
  3. 1 2 "McGill's Hanadi Sleiman wins 2021 Polanyi Award". McGill Institute for Advanced Materials. Retrieved 2023-03-03.
  4. Thurston, Meaghan (2022-09-21). "CFI invests $3.9 M in McGill research". McGill Reporter. Retrieved 2023-03-03.
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