Hydroxyacyl-thioester dehydratase type 2

HTD2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3IR3
Identifiers
Aliases	HTD2 , hydroxyacyl-thioester dehydratase type 2, mitochondrial, hydroxyacyl-thioester dehydratase type 2
External IDs	GeneCards: HTD2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	58,320,193 bp
RNA expression pattern
	Top expressed in
	muscle of leg; ; gastrocnemius muscle; ; skeletal muscle tissue; ; duodenum; ; islet of Langerhans; ; left ventricle; ; rectum; ; smooth muscle tissue; ; Stromal cell of endometrium; ; prefrontal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	lyase activity ; 3-hydroxyacyl-CoA dehydratase activity ;
Cellular component	nucleolus ; mitochondrion ; mitochondrial matrix ;
Biological process	fatty acid metabolic process ; lipid metabolism ; fatty-acyl-CoA biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	109703458
	n/a
	ENSG00000255154
	n/a
	P86397
	n/a
	NM_001348712 ; NM_001348713 ; NM_001348714 ; NM_001348715
	n/a
	NP_001335641 ; NP_001335642 ; NP_001335643 ; NP_001335644
	n/a
	Wikidata
View/Edit Human

Last updated June 09, 2022

Hydroxyacyl-thioester dehydratase type 2 is a protein that in humans is encoded by the HTD2 gene. ^[3]

Related Research Articles

Dehydratases are a group of lyase enzymes that form double and triple bonds in a substrate through the removal of water. They can be found in many places including the mitochondria, peroxisome and cytosol. There are more than 150 different dehydratase enzymes that are classified into four groups. Dehydratases can act on hydroxyacyl-CoA with or without cofactors, and some have a metal and non-metal cluster act as their active site.

Trifunctional enzyme subunit alpha, mitochondrial also known as hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, alpha subunit is a protein that in humans is encoded by the HADHA gene. Mutations in HADHA have been associated with trifunctional protein deficiency or long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency.

3-Hydroxyacyl ACP dehydrase Class of enzymes

3-Hydroxyacyl ACP dehydrase is an enzyme involved in fatty acid synthesis.

Delta-aminolevulinic acid dehydratase (porphobilinogen synthase, or ALA dehydratase, or aminolevulinate dehydratase) is an enzyme (EC 4.2.1.24) that in humans is encoded by the ALAD gene. Porphobilinogen synthase (or ALA dehydratase, or aminolevulinate dehydratase) synthesizes porphobilinogen through the asymmetric condensation of two molecules of aminolevulinic acid. All natural tetrapyrroles, including hemes, chlorophylls and vitamin B₁₂, share porphobilinogen as a common precursor. Porphobilinogen synthase is the prototype morpheein.

In enzymology, a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59) is an enzyme that catalyzes the chemical reaction

In enzymology, a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61) is an enzyme that catalyzes the chemical reaction

GPR113 is a gene that encodes the Probable G-protein coupled receptor 113 protein.

17-β-Hydroxysteroid dehydrogenase X (HSD10) also known as 3-hydroxyacyl-CoA dehydrogenase type-2 is a mitochondrial enzyme that in humans is encoded by the HSD17B10 gene. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. Human HSD10 cDNA was cloned from brain (NM_004493), and the resulting protein, a homotetramer, was first characterized as a short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD). Active sites of this enzyme can accommodate different substrates; 17β-HSD10 is involved in the oxidation of isoleucine, branched-chain fatty acids, and xenobiotics as well as the metabolism of sex hormones and neuroactive steroids.

D-bifunctional protein (DBP), also known as peroxisomal multifunctional enzyme type 2 (MFP-2), as well as 17β-hydroxysteroid dehydrogenase type IV is a protein that in humans is encoded by the HSD17B4 gene. It's an alcohol oxidoreductase, specifically 17β-Hydroxysteroid dehydrogenase. It is involved in fatty acid β-oxidation and steroid metabolism.

Pterin-4-alpha-carbinolamine dehydratase is an enzyme that in humans is encoded by the PCBD1 gene.

Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, also known as ECHS1, is a human gene.

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.

Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene.

GDP-mannose 4,6 dehydratase is an enzyme that in humans is encoded by the GMDS gene.

Pterin-4-alpha-carbinolamine dehydratase 2 is an enzyme that in humans is encoded by the PCBD2 gene.

Hydroxyacyl-Coenzyme A dehydrogenase (HADH) is an enzyme which in humans is encoded by the HADH gene.

3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase (EC 4.2.1.60, D-3-hydroxydecanoyl-[acyl-carrier protein] dehydratase, 3-hydroxydecanoyl-acyl carrier protein dehydrase, 3-hydroxydecanoyl-acyl carrier protein dehydratase, beta-hydroxydecanoyl thioester dehydrase, beta-hydroxydecanoate dehydrase, beta-hydroxydecanoyl thiol ester dehydrase, FabA, beta-hydroxyacyl-acyl carrier protein dehydratase, HDDase, beta-hydroxyacyl-ACP dehydrase, (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] hydro-lyase) is an enzyme with systematic name (3R)-3-hydroxydecanoyl-(acyl-carrier protein) hydro-lyase. This enzyme catalyses the following chemical reaction

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase is an enzyme with systematic name very-long-chain (3R)-3-hydroxyacyl-CoA hydro-lyase. This enzyme catalyses the following chemical reaction

2-hydroxyacyl-CoA lyase 1 is a protein that in humans is encoded by the HACL1 gene.

3-hydroxyacyl-CoA dehydratase 2 is a protein that in humans is encoded by the HACD2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000255154 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Hydroxyacyl-thioester dehydratase type 2" . Retrieved 2017-05-16.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Hydroxyacyl-thioester dehydratase type 2, mitochondrial

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000255154 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Hydroxyacyl-thioester dehydratase type 2" . Retrieved 2017-05-16.

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