ING5

ING5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3C6W
Identifiers
Aliases	ING5 , p28inhibitor of growth family member 5
External IDs	OMIM: 608525 MGI: 1922816 HomoloGene: 90955 GeneCards: ING5
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.3 Start 241,687,085 bp [1] End 241,729,478 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 D Start 93,731,687 bp [2] End 93,749,823 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right uterine tube body of pancreas right lobe of thyroid gland left lobe of thyroid gland pituitary gland anterior pituitary canal of the cervix minor salivary gland left uterine tube Top expressed in primitive streak medullary collecting duct otolith organ hand utricle cumulus cell retinal pigment epithelium ciliary body renal corpuscle secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function methylated histone binding protein binding metal ion binding chromatin binding Cellular component MOZ/MORF histone acetyltransferase complex nucleus nucleoplasm Biological process positive regulation of transcription, DNA-templated DNA replication negative regulation of growth regulation of transcription, DNA-templated histone acetylation histone H3 acetylation transcription, DNA-templated protein acetylation negative regulation of cell population proliferation positive regulation of apoptotic process regulation of signal transduction by p53 class mediator chromatin organization positive regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84289 66262 Ensembl ENSG00000168395 ENSMUSG00000026283 UniProt Q8WYH8 Q9D8Y8 RefSeq (mRNA) NM_032329 NM_001330161 NM_001330162 NM_025454 NM_029340 RefSeq (protein) NP_001317090 NP_001317091 NP_115705 NP_079730 Location (UCSC) Chr 2: 241.69 – 241.73 Mb Chr 1: 93.73 – 93.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene. ^{[5] [6]}

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. ^[6]

Interactions

ING5 has been shown to interact with EP300 ^[5] and P53. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000168395 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026283 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Res. 63 (10): 2373–8. PMID   12750254.
6. "Entrez Gene: ING5 inhibitor of growth family, member 5".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–865. doi: 10.1016/j.molcel.2004.09.016 . PMID   15383276.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.