![Interactive heat map of ratios of births on each day of the year to the average, in USA (top) and England and Wales (bottom)
[Legend and sources] Most common birthdays.svg](http://upload.wikimedia.org/wikipedia/commons/b/b6/Most_common_birthdays.svg)
Seasonal variation in human birth rate has been found to be a nearly universal phenomenon. [1] Also, birth seasonality has been found to be correlated with certain physiological and psychological traits of humans and animals [2] [3] and type I diabetes. [4] . Evidence for seasonality in humans is limited. [5]
The season in which babies are born can have a dramatic effect on their future risk relating to the development of conditions such as neurological disorders, including seasonal affective disorder, bipolar depression, schizophrenia [2] [6] and type I diabetes. [4] Research has shown that the season a baby is born in can have a major effect on whether or not they will become a heavy smoker. This even varies between men to women. [7]
Recently, large-scale population analytics have allowed for the exploration of birth month/season hypotheses among large cohorts of people. One study used 1.7 million patients from Columbia University in New York City (NYC) to confirm associations between neurological conditions, respiratory condition and reproductive conditions with birth month. [8] In addition, they uncovered an association between cardiovascular diseases and birth month. [9] This was subsequently confirmed in a separate study, also using data from NYC. [10] Researchers also explored mechanisms correlated with birth season in a large population study including data from 10.5 million patients, from three countries (US, South Korea, and Taiwan) and six study sites. [11] They found correlations between relative age and school cutoff periods. And that first trimester exposure to fine air particulates increased the risk of atrial fibrillation later in life. [12]
The season during which a birth takes place has been linked to the weight development of the infant as well as initial weight.[ citation needed ]
 | The examples and perspective in this article may not represent a worldwide view of the subject.(July 2023) |
There is evidence that suggests that children who are born earlier while they attend the same academic year with others, gain an advantage:
Birth rates of people who later die by suicide show disproportionate excess for April, May and June compared with the other months. Overall, the risk of suicide increases by 17% for people born in the spring–early summer compared with those born in the autumn–early winter; this risk increase was larger for women (29.6%) than for men (13.7%). [14]
Research works in Sweden show that those who preferred suicide by hanging rather than poisoning or petrol gases were significantly more likely to be born during February–April. Maximum of the month-of-birth curve for preferring hanging was for March–April and the minimum was for September–October. [15]
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Introduced by a group of US clinicians in the mid-1970s, the term was adopted by the American Psychiatric Association for this symptom cluster under mood disorders in the 1980 version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), and has become widely used since.
In genetics, the phenotype is the set of observable characteristics or traits of an organism. The term covers the organism's morphology, its developmental processes, its biochemical and physiological properties, its behavior, and the products of behavior. An organism's phenotype results from two basic factors: the expression of an organism's genetic code and the influence of environmental factors. Both factors may interact, further affecting the phenotype. When two or more clearly different phenotypes exist in the same population of a species, the species is called polymorphic. A well-documented example of polymorphism is Labrador Retriever coloring; while the coat color depends on many genes, it is clearly seen in the environment as yellow, black, and brown. Richard Dawkins in 1978 and then again in his 1982 book The Extended Phenotype suggested that one can regard bird nests and other built structures such as caddisfly larva cases and beaver dams as "extended phenotypes".
Hearing loss is a partial or total inability to hear. Hearing loss may be present at birth or acquired at any time afterwards. Hearing loss may occur in one or both ears. In children, hearing problems can affect the ability to acquire spoken language, and in adults it can create difficulties with social interaction and at work. Hearing loss can be temporary or permanent. Hearing loss related to age usually affects both ears and is due to cochlear hair cell loss. In some people, particularly older people, hearing loss can result in loneliness.
A mood disorder, also known as an affective disorder, is any of a group of conditions of mental and behavioral disorder where a disturbance in the person's mood is the main underlying feature. The classification is in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and International Classification of Diseases (ICD).
Seasonal affective disorder (SAD) is a mood disorder subset in which people who typically have normal mental health throughout most of the year exhibit depressive symptoms at the same time each year. It is commonly, but not always, associated with the reductions or increases in total daily sunlight hours that occur during the summer or winter.
Isotretinoin, also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication primarily used to treat severe acne. It is also used to prevent certain skin cancers, and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.
Depression is a mental state of low mood and aversion to activity. It affects more than 280 million people of all ages. Depression affects a person's thoughts, behavior, feelings, and sense of well-being. Depressed people often experience loss of motivation or interest in, or reduced pleasure or joy from, experiences that would normally bring them pleasure or joy. Depressed mood is a symptom of some mood disorders such as major depressive disorder and dysthymia; it is a normal temporary reaction to life events, such as the loss of a loved one; and it is also a symptom of some physical diseases and a side effect of some drugs and medical treatments. It may feature sadness, difficulty in thinking and concentration and a significant increase or decrease in appetite and time spent sleeping. People experiencing depression may have feelings of dejection or hopelessness and may experience suicidal thoughts. It can either be short term or long term.
There are more than 700,000 estimated suicide deaths every year. Suicide affects every demographic, yet there are some populations that are more impacted than others. For example, among 15–29 year olds, suicide is much more prominent; this being the fourth leading cause of death within this age group.
Biomedical text mining refers to the methods and study of how text mining may be applied to texts and literature of the biomedical domain. As a field of research, biomedical text mining incorporates ideas from natural language processing, bioinformatics, medical informatics and computational linguistics. The strategies in this field have been applied to the biomedical literature available through services such as PubMed.
Men's health is a state of complete physical, mental, and social well-being, as experienced by men, and not merely the absence of disease. Differences in men's health compared to women's can be attributed to biological factors, behavioural factors, and social factors.
The birthday effect is a statistical phenomenon where an individual's likelihood of death appears to increase on or close to their birthday. The birthday effect has been seen in studies of general populations in England and Wales, Switzerland, Ukraine, and the United States, as well as in smaller populations such as Major League Baseball players. Studies do not consistently show this effect; some studies find that men's and women's mortality rates diverge in the run-up to the birthday, while others find no significant gender effect. Suggested mechanisms for the effect include alcohol consumption, psychological stress relating to the birthday, increased suicide risk, terminally ill patients attempting to hold on until their birthday, an increased mortality salience, or a physiological cycle that causes the body to weaken annually. It has also been suggested that it may be a statistical artifact, perhaps as a result of anomalies in reporting, but the birthday effect has also been seen in studies that control for known reporting anomalies.
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.
Depression, one of the most commonly diagnosed psychiatric disorders, is being diagnosed in increasing numbers in various segments of the population worldwide. Depression in the United States alone affects 17.6 million Americans each year or 1 in 6 people. Depressed patients are at increased risk of type 2 diabetes, cardiovascular disease and suicide. Within the next twenty years depression is expected to become the second leading cause of disability worldwide and the leading cause in high-income nations, including the United States. In approximately 75% of suicides, the individuals had seen a physician within the prior year before their death, 45–66% within the prior month. About a third of those who died by suicide had contact with mental health services in the prior year, a fifth within the preceding month.
Schizophrenia affects around 0.3–0.7% of people at some point in their life, or 21 million people worldwide as of 2020. By using precise methods in its diagnosis and a large, representative population, schizophrenia seems to occur with relative consistency over time during the last half-century.
Research on seasonal effects on suicide rates suggests that the prevalence of suicide is greatest during the late spring and early summer months, despite the common belief that suicide rates peak during the cold and dark months of the winter season.
Joel Dudley is currently Associate Professor of Genetics and Genomic Sciences and founding Director of the Institute for Next Generation Healthcare at the Icahn School of Medicine at Mount Sinai. In March, 2018 Dr. Dudley was named Executive Vice President for Precision Health for the Mount Sinai Health System (MSHS). In 2017 he was awarded an Endowed Professorship by Mount Sinai in Biomedical Data Science. Prior to Mount Sinai, he held positions as Co-founder and Director of Informatics at NuMedii, Inc. and Consulting Professor of Systems Medicine in the Department of Pediatrics at Stanford University School of Medicine. His work is focused at the nexus of -omics, digital health, artificial intelligence (AI), scientific wellness, and healthcare delivery. His work has been featured in the Wall Street Journal, Scientific American, MIT Technology Review, CNBC, and other popular media outlets. He was named in 2014 as one of the 100 most creative people in business by Fast Company magazine. He is co-author of the book Exploring Personal Genomics from Oxford University Press. Dr. Dudley received a BS in Microbiology from Arizona State University and an MS and PhD in Biomedical Informatics from Stanford University School of Medicine.
In genetics and genetic epidemiology, a phenome-wide association study, abbreviated PheWAS, is a study design in which the association between single-nucleotide polymorphisms or other types of DNA variants is tested across a large number of different phenotypes. The aim of PheWAS studies is to examine the causal linkage between known sequence differences and any type of trait, including molecular, biochemical, cellular, and especially clinical diagnoses and outcomes. It is a complementary approach to the genome-wide association study, or GWAS, methodology. A fundamental difference between GWAS and PheWAS designs is the direction of inference: in a PheWAS it is from exposure to many possible outcomes, that is, from SNPs to differences in phenotypes and disease risk. In a GWAS, the polarity of analysis is from one or a few phenotypes to many possible DNA variants. The approach has proven useful in rediscovering previously reported genotype-phenotype associations, as well as in identifying new ones.
Nicholas Pierino Tatonetti is an American bioscientist who is Vice Chair of Operations in the Department of Computational Biomedicine and Associate Director of Computational Oncology in the Cancer Center at Cedars-Sinai Medical Center in Los Angeles, California.
Daniel Richard Masys is an American biotechnologist and academic. He is an Affiliate Professor of Biomedical and Health Informatics at the University of Washington.
The Observational Health Data Sciences and Informatics, or OHDSI is an international collaborative effort aimed at improving health outcomes through large-scale analytics of health data. The OHDSI effort includes diverse researchers and health databases worldwide, with its central coordinating center located at Columbia University.