John R. Yates

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John R. Yates
Alma mater University of Maine
University of Virginia
Known for Mass Spectrometry
AwardsBiemann Medal (2004)
Ralph N. Adams Award in Bioanalytical Chemistry (2015)
ACS Award in Analytical Chemistry (2015)
John B. Fenn Award (2019)
Scientific career
Fields Chemist
Institutions The Scripps Research Institute

John R. Yates III is an American chemist and Ernest W. Hahn Professor in the Departments of Molecular Medicine and Neurobiology at The Scripps Research Institute in La Jolla, California. He is currently editor-in-chief of the Journal of Proteome Research. He appeared on list of 2022, 2023 and 2024 Highly Cited Researchers, making him among the top one percent of most cited researchers in the world. [1] [2] [3]

His work is focused on developing tools and in proteomics and he specializes in mass spectrometry. He is best known for the development of the Sequest algorithm for automated peptide sequencing [4] [5] and Multidimensional Protein Identification Technology (MudPIT) [6] and data-independent acquisition. [7] His lab is known for its contribution to methods to identify structural changes in proteins in living cells as well as method to identify N-glycan processing and occupancy using mass spectrometry such as covalent protein painting, [8] and DeGlyPHER (Deglycosylation-dependent Glycan/Proteomic Heterogeneity Evaluation Report). [9] His laboratory has made important contributions to understanding the biochemical mechanisms behind the failure of △F508 cystic fibrosis ion transport regulator to mature. [10] [11]

References

  1. ↑ "13 Scripps Research faculty named to Highly Cited Researchers List". Scripps Research Magazine. Retrieved December 3, 2024.
  2. ↑ "Scripps Research scientists make annual Highly Cited Researchers list". www.scripps.edu. Retrieved December 3, 2024.
  3. ↑ "Numerous Scripps Research scientists named Highly Cited Researchers". www.scripps.edu. Retrieved December 3, 2024.
  4. ↑ Eng, Jimmy K.; McCormack, Ashley L.; Yates, John R. (November 1994). "An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database". Journal of the American Society for Mass Spectrometry. 5 (11): 976–989. Bibcode:1994JASMS...5..976E. doi: 10.1016/1044-0305(94)80016-2 . ISSN   1044-0305. PMID   24226387.
  5. ↑ The Invention of SEQUEST | Prof. John Yates III | SCP2018 . Retrieved April 14, 2024– via www.youtube.com.
  6. ↑ Washburn, Michael P.; Wolters, Dirk; Yates, John R. (March 2001). "Large-scale analysis of the yeast proteome by multidimensional protein identification technology". Nature Biotechnology. 19 (3): 242–247. doi:10.1038/85686. ISSN   1087-0156. PMID   11231557. S2CID   16796135.
  7. ↑ Venable, John D; Dong, Meng-Qiu; Wohlschlegel, James; Dillin, Andrew; Yates, John R (2004). "Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra" . Nature Methods. 1 (1): 39–45. doi:10.1038/nmeth705. ISSN   1548-7091. PMID   15782151. S2CID   9780065.
  8. ↑ Son, Ahrum; Pankow, Sandra; Bamberger, Tom Casimir; Yates, John R. (2023), Quantitative structural proteomics in living cells by covalent protein painting, Methods in Enzymology, vol. 679, Elsevier, pp. 33–63, doi:10.1016/bs.mie.2022.08.046, ISBN   978-0-323-99264-0, PMC   10262296 , PMID   36682868
  9. ↑ Baboo, Sabyasachi; Diedrich, Jolene K.; Martínez-Bartolomé, Salvador; Wang, Xiaoning; Schiffner, Torben; Groschel, Bettina; Schief, William R.; Paulson, James C.; Yates, John R. III (October 12, 2021). "DeGlyPHER: An Ultrasensitive Method for the Analysis of Viral Spike N-Glycoforms". Analytical Chemistry. 93 (40): 13651–13657. doi:10.1021/acs.analchem.1c03059. ISSN   0003-2700. PMC   8848675 . PMID   34597027.
  10. ↑ Pankow, Sandra; Bamberger, Casimir; Calzolari, Diego; Martínez-Bartolomé, Salvador; Lavallée-Adam, Mathieu; Balch, William E.; Yates, John R. (December 24, 2015). "∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis". Nature. 528 (7583): 510–516. Bibcode:2015Natur.528..510P. doi:10.1038/nature15729. ISSN   0028-0836. PMC   4826614 . PMID   26618866.
  11. ↑ Pankow, Sandra; Bamberger, Casimir; Yates, John R. (2019). "A posttranslational modification code for CFTR maturation is altered in cystic fibrosis". Science Signaling. 12 (562) eaan7984. doi:10.1126/scisignal.aan7984. ISSN   1945-0877. PMC   6464640 . PMID   30600261.


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