Late preterm infants are infants born at a gestational age between 34+0⁄7 weeks and 36+6⁄7 weeks. [1] They have higher morbidity and mortality rates than term infants (gestational age ≥37 weeks) due to their relative physiologic and metabolic immaturity, even though they are often the size and weight of some term infants. [2] [3] "Late preterm" has replaced "near term" to describe this group of infants, since near term incorrectly implies that these infants are "almost term" and only require routine neonatal care. [2]
In 2005, late-preterm births accounted for more than 70% of all preterm births (<37 weeks’ gestation), or approximately 377,000 infants. In fact, much of the increase in the preterm birth rate in recent years can be attributed to increases in late-preterm births. [1]
Several important factors that may predispose late-preterm infants to medical conditions associated with immaturity: [1]
At 34–35 weeks, the brain weight is only about 2⁄3 that of a full-term baby. This may lead to an increased risk of: [4] [5]
Late preterm infants have immature gastrointestinal function and feeding difficulties that predispose them to in increase in enterohepatic circulation, decreased stool frequency, dehydration, and hyperbilirubinemia. Feeding during the birth hospitalization may be transiently successful, but not sustained after discharge. Feeding difficulties are associated with relatively low oromotor tone, function, and neural maturation also predispose these infants to dehydration and hyperbilirubinemia. [1]
Late Preterm Infants have an increased risk of being underweight and stunted at 12 and 24 months of age versus term infants. [6]
Proper nutrition is essential for normal growth, optimal neurologic and cognitive development, immune protection, and long-term health.
The last trimester of pregnancy the fetus is expressing active amino acid transport, calcium, lipid transfer, and glucose facilitated diffusion. Delivery of the premature infant requires higher energy expenditure, but with inadequate intake the infant will have negative nitrogen balance. There are higher needs for Calcium, Phosphorus, and Vitamin D.
For every 10 kcal/kg increase in energy intake in the first week of life, there is a 4.6 points increase in MDI (Mental Development Index) at 18 months. For every 1 g/kg increase in protein intake in the first week of life, 8.2 point increase in MDI at 18 months. [7]
Factors such as hemodynamic stability, severe IUGR, respiratory, abdominal exam, whether feeding cues are present, and stable glucose could all effect the timing of nutrition. Some preterm infants will be NPO (nil per os). If infants are unable to start oral or enteral intake intravenous fluids may begin with amino acids or total parenteral nutrition.
According to the American Academy of Pediatrics section on breastfeeding recommendations are all infants should receive human milk.
Variables | 34-36 | 37-38 | 39-41 |
---|---|---|---|
Fetal Growth | |||
Weight gain, g | 13 | 11 | 10 |
Lean body mass gain, g | 10.5 | 7.2 | 6.6 |
Protein gain, g | 1.6 | 1.3 | 1.2 |
Requirements | |||
Energy, kcal | 127 | 115 | 110 |
Proteins, g | 3.1 | 2.5 | 2 |
Calcium, mg | 120-140 | 70-120 | 70-120 |
Phosphorus, mg | 60-90 | 35-75 | 35-75 |
Use caution when fortifying single nutrients to prevent alteration of protein/energy ratio. Center for Disease Control (CDC) recommends that sterile formulas and fortifiers be used when mom is not available. Powdered formula and HMF may be contaminants. Start with the mom's diet during breastfeeding. Mom should be eating adequate calories, protein, B vitamins and DHA.
Stomach Capacity | |
---|---|
Day 1 | 5-7 mls |
Day 3 | 22-27 mls |
Day 10 | 45-60 mls |
Adult | 900 mls |
Colostrum production can range from 26 to 56 mL the first day to 113-185 mL for day two. Although colostrum production is not voluminous, it can still meet the needs of the newborn.
Infant mortality is the death of an infant before the infant's first birthday. The occurrence of infant mortality in a population can be described by the infant mortality rate (IMR), which is the number of deaths of infants under one year of age per 1,000 live births. Similarly, the child mortality rate, also known as the under-five mortality rate, compares the death rate of children up to the age of five.
Intrauterine growth restriction (IUGR), or fetal growth restriction, refers to poor growth of a fetus while in the womb during pregnancy. IUGR is defined by clinical features of malnutrition and evidence of reduced growth regardless of an infant's birth weight percentile. The causes of IUGR are broad and may involve maternal, fetal, or placental complications.
Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age, as opposed to full-term delivery at approximately 40 weeks. Extreme preterm is less than 28 weeks, very early preterm birth is between 28 and 32 weeks, early preterm birth occurs between 32 and 34 weeks, late preterm birth is between 34 and 36 weeks' gestation. These babies are also known as premature babies or colloquially preemies or premmies. Symptoms of preterm labor include uterine contractions which occur more often than every ten minutes and/or the leaking of fluid from the vagina before 37 weeks. Premature infants are at greater risk for cerebral palsy, delays in development, hearing problems and problems with their vision. The earlier a baby is born, the greater these risks will be.
Infantile respiratory distress syndrome (IRDS), also called respiratory distress syndrome of newborn, or increasingly surfactant deficiency disorder (SDD), and previously called hyaline membrane disease (HMD), is a syndrome in premature infants caused by developmental insufficiency of pulmonary surfactant production and structural immaturity in the lungs. It can also be a consequence of neonatal infection and can result from a genetic problem with the production of surfactant-associated proteins.
Breast milk or mother's milk is milk produced by mammary glands located in the breast of a human female. Breast milk is the primary source of nutrition for newborns, containing fat, protein, carbohydrates and variable minerals and vitamins. Breast milk also contains substances that help protect an infant against infection and inflammation, whilst also contributing to healthy development of the immune system and gut microbiome.
Kangaroo Mother Care (KMC), which involves skin-to-skin contact (SSC), is an intervention to care for premature or low birth weight infants (LBW). The technique and intervention is the recommended evidence-based care for low birth weight infants by the World Health Organization (WHO) since 2003.
Fetal viability is the ability of a human fetus to survive outside the uterus. Medical viability is generally considered to be between 23 and 24 weeks gestational age. Viability depends upon factors such as birth weight, gestational age, and the availability of advanced medical care. In low-income countries, half of newborns born at or below 32 weeks gestational age died due to a lack of medical access; in high-income countries, the vast majority of newborns born above 24 weeks gestational age survive.
Low birth weight (LBW) is defined by the World Health Organization as a birth weight of an infant of 2,499 g or less, regardless of gestational age. Infants born with LBW have added health risks which require close management, often in a neonatal intensive care unit (NICU). They are also at increased risk for long-term health conditions which require follow-up over time.
Necrotizing enterocolitis (NEC) is a devastating intestinal disease that affects premature or very low birth weight infants. Symptoms may include poor feeding, bloating, decreased activity, blood in the stool, vomiting of bile, bowel death, multiorgan failure, and even death.
Neonatal jaundice is a yellowish discoloration of the white part of the eyes and skin in a newborn baby due to high bilirubin levels. Other symptoms may include excess sleepiness or poor feeding. Complications may include seizures, cerebral palsy, or kernicterus.
Antenatal steroids, also known as antenatal corticosteroids, are medications administered to pregnant women expecting a preterm birth. When administered, these steroids accelerate the maturation of the fetus' lungs, which reduces the likelihood of infant respiratory distress syndrome and infant mortality. The effectiveness of this corticosteroid treatment on humans was first demonstrated in 1972 by Sir Graham Liggins and Ross Howie, during a randomized control trial using betamethasone.
Nutrition and pregnancy refers to the nutrient intake, and dietary planning that is undertaken before, during and after pregnancy. Nutrition of the fetus begins at conception. For this reason, the nutrition of the mother is important from before conception as well as throughout pregnancy and breastfeeding. An ever-increasing number of studies have shown that the nutrition of the mother will have an effect on the child, up to and including the risk for cancer, cardiovascular disease, hypertension and diabetes throughout life.
Breastfeeding difficulties refers to problems that arise from breastfeeding, the feeding of an infant or young child with milk from a woman's breasts. Although babies have a sucking reflex that enables them to suck and swallow milk, and human breast milk is usually the best source of nourishment for human infants, there are circumstances under which breastfeeding can be problematic, or even in rare instances, contraindicated.
Breastfeeding, or nursing, is the process by which human breast milk is fed to a child. Breast milk may be from the breast, or may be pumped and fed to the infant. The World Health Organization (WHO) recommends that breastfeeding begin within the first hour of a baby's life and continue as often and as much as the baby wants. Health organizations, including the WHO, recommend breastfeeding exclusively for six months. This means that no other foods or drinks, other than vitamin D, are typically given. WHO recommends exclusive breastfeeding for the first 6 months of life, followed by continued breastfeeding with appropriate complementary foods for up to 2 years and beyond. Of the 135 million babies born every year, only 42% are breastfed within the first hour of life, only 38% of mothers practice exclusive breastfeeding during the first six months, and 58% of mothers continue breastfeeding up to the age of two years and beyond.
Lactation describes the secretion of milk from the mammary glands and the period of time that a mother lactates to feed her young. The process naturally occurs with all sexually mature female mammals, although it may predate mammals. The process of feeding milk in all female creatures is called nursing, and in humans it is also called breastfeeding. Newborn infants often produce some milk from their own breast tissue, known colloquially as witch's milk.
The Baby Friendly Hospital Initiative (BFHI), also known as Baby Friendly Initiative (BFI), is a worldwide programme of the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF), launched in 1992 in India following the adoption of the Innocenti Declaration on breastfeeding promotion in 1990. The initiative is a global effort for improving the role of maternity services to enable mothers to breastfeed babies for the best start in life. It aims at improving the care of pregnant women, mothers and newborns at health facilities that provide maternity services for protecting, promoting and supporting breastfeeding, in accordance with the International Code of Marketing of Breast-milk Substitutes.
Neonatal sepsis is a type of neonatal infection and specifically refers to the presence in a newborn baby of a bacterial blood stream infection (BSI) in the setting of fever. Older textbooks may refer to neonatal sepsis as "sepsis neonatorum". Criteria with regards to hemodynamic compromise or respiratory failure are not useful clinically because these symptoms often do not arise in neonates until death is imminent and unpreventable. Neonatal sepsis is divided into two categories: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis presenting in the first 7 days of life, with LOS referring to presentation of sepsis after 7 days. Neonatal sepsis is the single most common cause of neonatal death in hospital as well as community in developing country.
Infant feeding is the practice of feeding infants. Breast milk provides the best nutrition when compared to infant formula. Infants are usually introduced to solid foods at around four to six months of age.
Human milk immunity is the protection provided to the immune system of an infant via the biologically active components in human milk. Human milk was previously thought to only provide passive immunity primarily through Secretory IgA, but advances in technology have led to the identification of various immune-modulating components. Human milk constituents provide nutrition and protect the immunologically naive infant as well as regulate the infant's own immune development and growth.
The first 1000 days describes the period from conception to 24 months of age in child development. This is considered a "critical period" in which sufficient nutrition and environmental factors have life-long effects on a child's overall health. While adequate nutrition can be exceptionally beneficial during this critical period, inadequate nutrition may also be detrimental to the child. This is because children establish many of their lifetime epigenetic characteristics in their first 1000 days. Medical and public health interventions early on in child development during the first 1000 days may have higher rates of success compared to those achieved outside of this period.