| # | Weekend End Date | Film | Weekend Gross (millions) | Notes |
|---|
| 1 | January 1, 2006 | The Chronicles of Narnia: The Lion, the Witch and the Wardrobe | $2.21 | |
| 2 | January 8, 2006 | The Chronicles of Narnia: The Lion, the Witch and the Wardrobe | $1.71 | Hostel was #1 in North America. |
| 3 | January 15, 2006 | The Chronicles of Narnia: The Lion, the Witch and the Wardrobe | $0.98 | Glory Road was #1 in North America. |
| 4 | January 22, 2006 | Underworld: Evolution | $2.16 | |
| 5 | January 29, 2006 | Nanny McPhee | $1.10 | Big Momma's House 2 was #1 in North America. |
| 6 | February 5, 2006 | When a Stranger Calls | $1.38 | |
| 7 | February 12, 2006 | The Pink Panther | $1.71 | |
| 8 | February 19, 2006 | Eight Below | $1.93 | |
| 9 | February 26, 2006 | Eight Below | $1.46 | Madea's Family Reunion was #1 in North America. |
| 10 | March 5, 2006 | Eight Below | $1.04 | Madea's Family Reunion was #1 in North America. |
| 11 | March 12, 2006 | Failure to Launch | $1.46 | |
| 12 | March 19, 2006 | V for Vendetta | $2.08 | |
| 13 | March 26, 2006 | Inside Man | $2.33 | |
| 14 | April 2, 2006 | Ice Age: The Meltdown | $4.71 | |
| 15 | April 9, 2006 | Ice Age: The Meltdown | N/A | |
| 16 | April 16, 2006 | Scary Movie 4 | $3.47 | |
| 17 | April 23, 2006 | Silent Hill | $1.41 | |
| 18 | April 30, 2006 | RV | $1.19 | |
| 19 | May 7, 2006 | Mission: Impossible III | $4.40 | |
| 20 | May 14, 2006 | Mission: Impossible III | $2.21 | |
| 21 | May 21, 2006 | The Da Vinci Code | $8.72 | The Da Vinci Code had the highest weekend debut of 2006. |
| 22 | May 28, 2006 | X-Men: The Last Stand | $7.57 | |
| 23 | June 4, 2006 | X-Men: The Last Stand | $3.28 | The Break-Up was #1 in North America. |
| 24 | June 11, 2006 | Cars | $2.75 | |
| 25 | June 18, 2006 | The Fast and the Furious: Tokyo Drift | $1.71 | Cars was #1 in North America. |
| 26 | June 25, 2006 | Click | $2.41 | |
| 27 | July 2, 2006 | Superman Returns | $4.01 | |
| 28 | July 9, 2006 | Pirates of the Caribbean: Dead Man's Chest | $8.36 | Pirates of the Caribbean: Dead Man's Chest had the highest weekend debut of 2006 in North America. |
| 29 | July 16, 2006 | Pirates of the Caribbean: Dead Man's Chest | $5.12 | |
| 30 | July 23, 2006 | Pirates of the Caribbean: Dead Man's Chest | $3.51 | |
| 31 | July 30, 2006 | Miami Vice | $2.27 | |
| 32 | August 6, 2006 | Talladega Nights: The Ballad of Ricky Bobby | $2.39 | |
| 33 | August 13, 2006 | Step Up | $1.77 | Talladega Nights: The Ballad of Ricky Bobby was #1 in North America. |
| 34 | August 20, 2006 | Snakes on a Plane | $1.18 | |
| 35 | August 27, 2006 | Invincible | $0.88 | |
| 36 | September 3, 2006 | Crank | $0.81 | Invincible was #1 in North America. |
| 37 | September 10, 2006 | The Covenant | $0.77 | |
| 38 | September 17, 2006 | Gridiron Gang | $0.93 | |
| 39 | September 24, 2006 | Jackass Number Two | $2.19 | |
| 40 | October 1, 2006 | Open Season | $1.92 | |
| 41 | October 8, 2006 | The Departed | $2.13 | The Departed won the 79th Academy Award for Best Motion Picture of the Year. |
| 42 | October 15, 2006 | The Departed | $1.82 | The Grudge 2 was #1 in North America. |
| 43 | October 22, 2006 | The Prestige | $1.53 | |
| 44 | October 29, 2006 | Saw III | $2.45 | |
| 45 | November 5, 2006 | Borat: Cultural Learnings of America for Make Benefit Glorious Nation of Kazakhstan | $2.35 | |
| 46 | November 12, 2006 | Borat: Cultural Learnings of America for Make Benefit Glorious Nation of Kazakhstan | $3.55 | |
| 47 | November 19, 2006 | Casino Royale | $5.24 | Happy Feet was #1 in North America. |
| 48 | November 26, 2006 | Casino Royale | $3.31 | Happy Feet was #1 in North America. |
| 49 | December 3, 2006 | Casino Royale | $2.36 | Happy Feet was #1 in North America. |
| 50 | December 10, 2006 | Casino Royale | $1.44 | Apocalypto was #1 in North America. |
| 51 | December 17, 2006 | The Pursuit of Happyness | $1.53 | |
| 52 | December 24, 2006 | Night at the Museum | $1.28 | |
| 53 | December 31, 2006 | Night at the Museum | $2.83 | |
