| Year | Category | Nominee(s) | Episode | Result |
|---|
| 2000 | Outstanding Directing for a Comedy Series | Todd Holland | "Pilot" | Won |
| Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Red Dress" | Nominated |
| Outstanding Guest Actress in a Comedy Series | Bea Arthur | "Water Park" | Nominated |
| Outstanding Writing for a Comedy Series | Linwood Boomer | "Pilot" | Won |
| Outstanding Casting for a Comedy Series | Ken Miller, Mary V. Buck, Nikki Valko, Susan Edelman | | Nominated |
| 2001 | Outstanding Comedy Series | Linwood Boomer, Bob Stevens, Gary Murphy, Neil Thompson, Alan J. Higgins, Michael Glouberman, Andrew Orenstein, Todd Holland, Alex Reid, James Simons, Ken Kwapis, Jeff Melman | | Nominated |
| Outstanding Directing for a Comedy Series | Todd Holland | "Bowling" | Won |
| Jeff Melman | "Flashback" | Nominated |
| Outstanding Lead Actor in a Comedy Series | Frankie Muniz | "Bowling" | Nominated |
| Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Flashback" | Nominated |
| Outstanding Guest Actor in a Comedy Series | Robert Loggia | "Grandparents" | Nominated |
| Outstanding Guest Actress in a Comedy Series | Cloris Leachman | "Grandparents" | Nominated |
| Outstanding Writing for a Comedy Series | Alex Reid | "Bowling" | Won |
| 2002 | Outstanding Directing for a Comedy Series | Jeff Melman | "Christmas" | Nominated |
| Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Poker" | Nominated |
| Outstanding Supporting Actor in a Comedy Series | Bryan Cranston | "Poker" / "Monkey" | Nominated |
| Outstanding Guest Actress in a Comedy Series | Cloris Leachman | "Christmas" | Won |
| Susan Sarandon | "Company Picnic" | Nominated |
| Outstanding Stunt Coordination | Bobby Porter | "Company Picnic" | Nominated |
| 2003 | Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Baby" | Nominated |
| Outstanding Supporting Actor in a Comedy Series | Bryan Cranston | "Malcolm Holds His Tongue" / "Day Care" | Nominated |
| Outstanding Guest Actress in a Comedy Series | Cloris Leachman | | Nominated |
| Outstanding Single Camera Picture Editing for a Comedy Series | Mark Scheib, Steve Welch | "If Boys Were Girls" | Won |
| 2004 | Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Block Party" | Nominated |
| Outstanding Guest Actress in a Comedy Series | Cloris Leachman | | Nominated |
| Outstanding Choreography | Fred Tallaksen | "Dewey's Special Class" | Nominated |
| 2005 | Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Lois Battles Jamie" | Nominated |
| Outstanding Guest Actress in a Comedy Series | Cloris Leachman | | Nominated |
| Outstanding Music and Lyrics | Charles Sydnor, Eric Kaplan | "Song: "The Married Bed"
Episode: "Dewey's Opera" | Nominated |
| 2006 | Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Lois Strikes Back" | Nominated |
| Outstanding Supporting Actor in a Comedy Series | Bryan Cranston | "College Recruiters" / "Hal Grieves" | Nominated |
| Outstanding Guest Actress in a Comedy Series | Cloris Leachman | | Won |
| Outstanding Choreography | Fred Tallaksen | "Bomb Shelter" | Nominated |
