Lobaplatin

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Lobaplatin
Lobaplatin.svg
Clinical data
Routes of
administration 		IV Bolus Injections or Infusion
Identifiers
  • 1,2-diammino-methy lcyclobutane-platinum (II) lactate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
CompTox Dashboard (EPA)
Chemical and physical data
Formula C9H18N2O3Pt
Molar mass 397.338 g·mol−1
Melting point 220 °C (428 °F)
Solubility in water 72.9 mg/mL (20 °C)

Lobaplatin is a platinum-based antineoplastic metallodrug approved exclusively in China for the treatment of small cell lung cancer, inoperable metastatic breast cancer and chronic myelogenous leukaemia. [1] The drug is a third-generation analogue of cisplatin, the first globally approved and widely used platinum-based anticancer drug.

Contents

Pharmacodynamics studies of lobaplatin found greater anticancer activity and lower toxicity than cisplatin and carboplatin, and showed activity against cisplatin-resistant cancer cells. [1] However, global approval of lobaplatin is restricted due to limited evidence of efficacy.

Structure

The structure of lobaplatin (1,2-diammino-methyl-cyclobutane-platinum (II) lactate) consists of a platinum(II) metal center coordinated to a bidentate amine ligand (1,2-bis(aminomethyl)cyclobutane) and a lactic acid leaving group. [2] Lobaplatin is administered intravenously by bolus injection or infusion and composed of an approximate 50/50 mixture of two diastereoisomers, R,R,S- and S,S,S-configurations. [3]

Mechanism of action

The mechanism of antineoplastic action for lobaplatin has not been studied in great detail. The results of current mechanistic studies suggest that lobaplatin is a DNA cross linking antineoplastic agent and has a similar platinum-induced cytotoxicity mechanism to other platin metallodrugs (i.e., cisplatin and oxaliplatin). [4]

Lobaplatin acts as a pro-drug, it is hydrolyzed in the body forming an active form that is able to interact with DNA. [5] Specifically, when lobaplatin is hydrolyzed the lactate ligand is protonated and dissociates as lactic acid, forming a charged and highly reactive platinum complex that coordinates with the N-donors of DNA bases and inhibits DNA synthesis. [6] In its reactive (active) form, the platinum metal center is able to form DNA-adducts through inter- and intra-strand cross-links with two adjacent guanine-guanine (GG) or two guanine-adenine (GA) bases, inducing apoptosis and inhibition of cell growth. [2] Lobaplatin has been shown to affect the expression of the c-myc gene, which is associated with apoptosis and cell proliferation. [7]

Toxicity and side effects

The toxicity of platinum-based drugs is highly dependent on how easily the leaving group(s) are hydrolyzed, leaving groups that easily dissociate are significantly more toxic than more stable leaving groups that don't easily disassociate. [3] Due to the good stability of the lactic acid leaving group, lobaplatin is more stable and therefore less toxic than first and second generation platinum-based drugs. [6]

The toxicity of lobaplatin is common across multiple clinical trials, 60 mg/m2 (body surface area) per 3–4 weeks is the maximum tolerated dose and the dose-limiting toxicity is thrombocytopenia. [2] Common side effects include agranulocytosis, thrombocytopenia, anaemia, leukopenia, nausea and vomiting. [3] [1]

History

Lobaplatin was first synthesized and developed by ASTA Pharma in Germany in 1990 , under the research name D-19466. [8] Discontinued development of lobaplatin by ASTA Pharma lead to further development of the drug by Zentaris AG (AEterna Laboratories). [8] In 2003, Zentaris AG signed a contract with Hainan Tianwang International Pharmaceutical for the manufacturing and marketing of lobaplatin in China. [8] In 2010, lobaplatin was approved for clinical use in china, according to China Food and Drug Administration.

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References

  1. 1 2 3 "Lobaplatin: D 19466". Drugs in R&D. 4 (6): 369–372. 2003. doi:10.2165/00126839-200304060-00008. PMID   14584968.
  2. 1 2 3 McKeage MJ (January 2001). "Lobaplatin: a new antitumour platinum drug". Expert Opinion on Investigational Drugs. 10 (1): 119–128. doi:10.1517/13543784.10.1.119. PMID   11116285. S2CID   23771556.
  3. 1 2 3 Wheate NJ, Walker S, Craig GE, Oun R (September 2010). "The status of platinum anticancer drugs in the clinic and in clinical trials". Dalton Transactions. 39 (35): 8113–8127. doi:10.1039/c0dt00292e. hdl: 2123/9269 . PMID   20593091.
  4. ↑ Boulikas T (2008-11-21). "Platinum Drugs". In Missailidis S, Pantos A, Bellis E, Christofis P (eds.). Anticancer Therapeutics, S. Missailidis (Ed.). Chichester, UK: John Wiley & Sons, Ltd. pp. 55–78. doi:10.1002/9780470697047.ch5. ISBN   978-0-470-69704-7.
  5. ↑ Saygin D, Tabib T, Bittar HE, Valenzi E, Sembrat J, Chan SY, et al. (October 2016). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary Circulation. 10 (1): 115–122. doi:10.1016/j.cplett.2016.10.004. PMC   7052475 . PMID   32166015.
  6. 1 2 "NCI Dictionaries: Lobaplatin". National Cancer Institute. U.S. Department of Health and Human Services. 2011-02-02. Retrieved 2022-10-09.
  7. ↑ Eliopoulos AG, Kerr DJ, Maurer HR, Hilgard P, Spandidos DA (June 1995). "Induction of the c-myc but not the cH-ras promoter by platinum compounds". Biochemical Pharmacology. 50 (1): 33–38. doi:10.1016/0006-2952(95)00085-e. PMID   7605342.
  8. 1 2 3 Voegeli R, Schumacher W, Engel J, Respondek J, Hilgard P (September 1990). "D-19466, a new cyclobutane-platinum complex with antitumor activity". Journal of Cancer Research and Clinical Oncology. 116 (5): 439–442. doi:10.1007/bf01612990. PMID   2229133. S2CID   9620899.
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