Luciano Fadiga

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Luciano Fadiga Luciano fadiga.JPG
Luciano Fadiga

Luciano Fadiga (born 8 August 1961) is a neurophysiologist at the Human Physiology Section of the University of Ferrara and a Senior Researcher at the Istituto Italiano di Tecnologia of Genoa, Italy.

Born in 1961. M.D., University of Bologna, Ph.D. in Neuroscience, University of Parma. Senior Researcher at the University of Parma since 1992. He is actually Professor of Human Physiology at the University of Ferrara and Senior Researcher at the Italian Institute of Technology. He has a long experience in electrophysiology and neurophysiology in monkeys (single-neuron recordings) and humans (transcranial magnetic stimulation, study of spinal excitability, brain imaging, recording of single neurons in awake neurosurgery patients).

Among his contributions:

  1. The description of the functional properties of the monkey ventral premotor cortex. During this time Fadiga, together with his Parma colleagues, discovered mirror neurons, a class of neurons that respond both when the monkey performs actions and when it observes similar actions made by other individuals. Fadiga has suggested that these neurons unify perception and action and may contribute to others’ action understanding (Experimental Brain Research, 1992; Brain, 1996; Cognitive Brain Research, 1996).
  2. The first demonstration that a mirror system exists also in humans. He achieved this result by applying transcranial magnetic stimulation (TMS) on the hand motor cortex of human subjects while they were observing others' actions. He demonstrated that the amplitude of observer’s hand muscle potentials, as evoked by TMS, was specifically and significantly modulated by the observed actions (Journal of Neurophysiology 1995).
  3. The study of peripersonal space representation in monkey premotor cortex (Science, 1997).
  4. The demonstration that a similar motor resonance is activated during speech listening and involves tongue-related motor centers (European Journal of Neuroscience, 2002). He recently further demonstrates that this motor activation evoked by speech listening is functional to speech perception. This result shows for the first time a causal relationship between action representation and perception (The motor somatotopy of speech perception, Current Biology, 2009).
  5. The first demonstration that, in humans, the frontal area for speech production (Broca’s area) is almost constantly activated by action observation (by several brain imaging experiments carried out in collaboration with San Raffaele Hospital of Milan, USC and UCLA of Los Angeles, HUT of Helsinki, Juelich Brain Imaging Center, Royal Holloway University of London) (Experimental Brain Research 1996).
  6. The very recent demonstration that Broca’s area activation reflects a primary role played by this area in pragmatically understanding actions of others (Brain, 2009).

Fadiga is currently leading a group of researchers at the University of Ferrara. He is coordinating a project on neuro-rehabilitation of stroke patients by action observation. He is leading a group of researchers at the Italian Institute of Technology to investigate the possibility to establish hardware communication between the human brain and some artificial device (brain-machine interfaces). Other fields of his research concern attention and its neural mechanisms in normal subjects and patients. He has been involved in RobotCub, CONTACT, and Poeticon EU projects, he is currently working in Siempre and Poeticon++ EU Projects. He is interacting with roboticists in order to perform experiments on artefacts that would never be possible in living subjects. Within EU-IST, he is a strong supporter of the emerging cultural domain which is neurorobotics.

Fadiga is reviewer of many international neuroscience journals, he was principal investigator in CNR projects on reaching-grasping, he directs several European Projects on action and speech recognition and control, he was co-investigator in Human Frontier Science Program and McDonnel-Pew funded projects, he has published more than 100 peer-reviewed publications in international journals. His work has received about 35,000 citations (H-Index, 56. Source: Google Scholar. Luciano Fadiga has been member and Chair of the SH4 Panel (Starting and Consolidator Grants) of the European Research Council (ERC).

Related Research Articles

Brocas area Speech production region in the dominant hemisphere of the hominid brain

Broca's area, or the Broca area, is a region in the frontal lobe of the dominant hemisphere, usually the left, of the brain with functions linked to speech production.

Parietal lobe Part of the brain responsible for sensory input and some language processing

The parietal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The parietal lobe is positioned above the temporal lobe and behind the frontal lobe and central sulcus.

Brodmann area 44

Brodmann area 44, or BA44, is part of the frontal cortex in the human brain. Situated just anterior to premotor cortex (BA6) and on the lateral surface, inferior to BA9.

A mirror neuron is a neuron that fires both when an animal acts and when the animal observes the same action performed by another. Thus, the neuron "mirrors" the behavior of the other, as though the observer were itself acting. Such neurons have been directly observed in human and primate species, and birds.

Motor cortex Region of the cerebral cortex

The motor cortex is the region of the cerebral cortex involved in the planning, control, and execution of voluntary movements. Classically, the motor cortex is an area of the frontal lobe located in the posterior precentral gyrus immediately anterior to the central sulcus.

Supplementary eye field Region of the frontal cortex of the brain

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Premotor cortex

The premotor cortex is an area of the motor cortex lying within the frontal lobe of the brain just anterior to the primary motor cortex. It occupies part of Brodmann's area 6. It has been studied mainly in primates, including monkeys and humans. The functions of the premotor cortex are diverse and not fully understood. It projects directly to the spinal cord and therefore may play a role in the direct control of behavior, with a relative emphasis on the trunk muscles of the body. It may also play a role in planning movement, in the spatial guidance of movement, in the sensory guidance of movement, in understanding the actions of others, and in using abstract rules to perform specific tasks. Different subregions of the premotor cortex have different properties and presumably emphasize different functions. Nerve signals generated in the premotor cortex cause much more complex patterns of movement than the discrete patterns generated in the primary motor cortex.

Simulation theory of empathy is a theory that holds that humans anticipate and make sense of the behavior of others by activating mental processes that, if carried into action, would produce similar behavior. This includes intentional behavior as well as the expression of emotions. The theory states that children use their own emotions to predict what others will do. Therefore, we project our own mental states onto others.
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Biological motion Motion that comes from actions of a biological organism

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