M. G. Finn | |
---|---|
Born | |
Alma mater | California Institute of Technology (BS) Massachusetts Institute of Technology (PhD) |
Known for | Click chemistry |
Awards | |
Scientific career | |
Fields | Chemistry |
Institutions | University of Virginia Scripps Research Institute Georgia Tech |
Thesis | On the mechanism of titanium-tartrate catalyzed asymmetric epoxidation (1986) |
Doctoral advisor | Barry Sharpless |
Other academic advisors | Fred C. Anson James P. Collman |
Website | www |
M. G. Finn (born October 23, 1958) is an American chemist and professor at the Georgia Institute of Technology.
Finn was born in Atlantic City, New Jersey, on October 23, 1958. [1] He studied chemistry at California Institute of Technology while receiving a Eastman Kodak scholarship [2] and performing undergraduate research under the direction of electrochemist Fred C. Anson. [3] After receiving his Bachelor of Science degree in June 1980, Finn spent the summer performing research at Eastman Kodak in Rochester, New York before joining the group of future Nobel prize winner, Barry Sharpless, that fall at the Massachusetts Institute of Technology, where he gained his PhD in 1986 with his thesis "On the mechanism of titanium-tartrate catalyzed asymmetric epoxidation". [4] [1]
After receiving his doctorate, Finn carried out postdoctoral research for two years with James P. Collman at Stanford University, before joining the faculty of University of Virginia in 1988. He moved to the Scripps Research Institute in 1998 (where his former PhD supervisor Barry Sharpless had previously moved to in 1990) and later to Georgia Tech in 2013, [5] where he currently holds the James A. Carlos Family Chair for Pediatric Technology, and is chief scientific officer of the Children's healthcare of Atlanta Pediatric Technology Center. [6] [7]
Finn's research concentrates on the development of methods for the synthesis of biologically-important molecules, such as functional virus-like particles. He coined the term Click chemistry with Barry Sharpless and Hartmuth C. Kolb. He also works on the mechanism and optimisation of copper-catalysed azide-alkyl cycloaddition; on targeted synthesis of enzyme inhibitors and antivirals; on bio-conjugation and chemical materials science; on the immunology of carbohydrates; and with new methods of enzyme development.
His laboratory works with viruses as building-blocks for targeted development of biologically active molecules.
Finn became the Editor-in-Chief of ACS Combinatorial Science in 2010. [8] [9]
In 2013, Thomson Reuters suggested that Finn could potentially win a Nobel prize for his ground-breaking work on click chemistry. [10]
Finn's full first name is M.G. He and his wife, Beth, have two children, Allison and Marc. [7]
Ryōji Noyori is a Japanese chemist. He won the Nobel Prize in Chemistry in 2001, Noyori shared a half of the prize with William S. Knowles for the study of chirally catalyzed hydrogenations; the second half of the prize went to K. Barry Sharpless for his study in chirally catalyzed oxidation reactions.
The Sharpless epoxidation reaction is an enantioselective chemical reaction to prepare 2,3-epoxyalcohols from primary and secondary allylic alcohols. The oxidizing agent is tert-butyl hydroperoxide. The method relies on a catalyst formed from titanium tetra(isopropoxide) and diethyl tartrate.
In organic chemistry, an epoxide is a cyclic ether with a three-atom ring. This ring approximates an equilateral triangle, which makes it strained, and hence highly reactive, more so than other ethers. They are produced on a large scale for many applications. In general, low molecular weight epoxides are colourless and nonpolar, and often volatile.
Karl Barry Sharpless is an American chemist and a two-time Nobel laureate in Chemistry known for his work on stereoselective reactions and click chemistry.
The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all degree levels and in all fields of chemistry, chemical engineering, and related fields. It is one of the world's largest scientific societies by membership. The ACS is a 501(c)(3) non-profit organization and holds a congressional charter under Title 36 of the United States Code. Its headquarters are located in Washington, D.C., and it has a large concentration of staff in Columbus, Ohio.
Scripps Research, previously known as The Scripps Research Institute (TSRI), is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institute has over 170 laboratories employing 2,100 scientists, technicians, graduate students, and administrative and other staff, making it the largest private, non-profit biomedical research organization in the United States and among the largest in the world.
In chemical synthesis, "click" chemistry is a class of biocompatible small molecule reactions commonly used in bioconjugation, allowing the joining of substrates of choice with specific biomolecules. Click chemistry is not a single specific reaction, but describes a way of generating products that follow examples in nature, which also generates substances by joining small modular units. In many applications, click reactions join a biomolecule and a reporter molecule. Click chemistry is not limited to biological conditions: the concept of a "click" reaction has been used in chemoproteomic, pharmacological, and various biomimetic applications. However, they have been made notably useful in the detection, localization and qualification of biomolecules.
Kyriacos Costa Nicolaou is a Cypriot-American chemist known for his research in the area of natural products total synthesis. He is currently Harry C. and Olga K. Wiess Professor of Chemistry at Rice University, having previously held academic positions at The Scripps Research Institute/UC San Diego and the University of Pennsylvania.
Mostafa A. El-Sayed is an Egyptian-American physical chemist, a leading nanoscience researcher, a member of the National Academy of Sciences and a US National Medal of Science laureate. He was the editor-in-chief of the Journal of Physical Chemistry during a critical period of growth. He is also known for the spectroscopy rule named after him, the El-Sayed rule.
ACS Combinatorial Science, formerly Journal of Combinatorial Chemistry (1999-2010), was a peer-reviewed scientific journal, published since 1999 by the American Chemical Society. ACS Combinatorial Science publishes articles, reviews, perspectives, accounts and reports in the field of Combinatorial Chemistry. JCS is currently indexed in: Chemical Abstracts Service (CAS), SCOPUS, EBSCOhost, PubMed, and Web of Science.
Henry Frederick "Fritz" Schaefer III is a computational and theoretical chemist. He is one of the most highly cited chemists in the world, with a Thomson Reuters H-Index of 121 as of 2020. He is the Graham Perdue Professor of Chemistry and Director of the Center for Computational Chemistry at the University of Georgia. Before becoming professor at Georgia he was professor at University of California, Berkley and in 2004, he became Professor of Chemistry Emeritus, at UC Berkeley
Frank Albert Cotton FRS was an American chemist. He was the W.T. Doherty-Welch Foundation Chair and Distinguished Professor of Chemistry at Texas A&M University. He authored over 1600 scientific articles. Cotton was recognized for his research on the chemistry of the transition metals.
Dale Lester Boger is an American medicinal and organic chemist and former chair of the Department of Chemistry at The Scripps Research Institute in La Jolla, CA.
Chad Alexander Mirkin is an American chemist. He is the George B. Rathmann professor of chemistry, professor of medicine, professor of materials science and engineering, professor of biomedical engineering, and professor of chemical and biological engineering, and director of the International Institute for Nanotechnology and Center for Nanofabrication and Molecular Self-Assembly at Northwestern University.
Morten Peter Meldal is a Danish chemist. He is a professor of Chemistry at the University of Copenhagen in Copenhagen, Denmark. He is best known for developing the CuAAC-click reaction, concurrent with but independent of Valery V. Fokin and K. Barry Sharpless.
William R. Roush is an American organic chemist. He was born on February 20, 1952 in Chula Vista, California. Roush studied chemistry at the University of California Los Angeles and Harvard University. Following a year postdoctoral appointment at Harvard, he joined that faculty at the Massachusetts Institute of Technology. In 1987, Dr. Roush moved to Indiana University and was promoted to Professor in 1989 and Distinguished Professor in 1995. Two years later, he moved to the University of Michigan in Ann Arbor and served as the Warner Lambert/Parke Davis Professor of Chemistry. He served as chair of the University of Michigan's Department of Chemistry from 2002-2004. In 2004 Professor Roush relocated with his group to the Jupiter, Florida campus of the Scripps Research Institute (TSRI) where he is currently an emeritus professor.
The Chemical Pioneer Award, established in 1966, is awarded by the American Institute of Chemists to recognize chemists or chemical engineers who have made outstanding contributions to advances in chemistry or the chemical profession.
Vicki Helene Grassian is the Chair of the Department of Chemistry and Biochemistry at the University of California, San Diego. She is also a Distinguished Professor in the Departments of Chemistry and Biochemistry, NanoEngineering, and Scripps Institution of Oceanography and holds the Distinguished Chair in Physical Chemistry.
Tsutomu Katsuki was an organic chemist who primarily focused on asymmetric oxidation reactions utilizing transition metal catalysts.
Hartmuth Christian Kolb is a German chemist. He is considered one of the founders of click chemistry.