MED10

Last updated
MED10
Identifiers
Aliases MED10 , NUT2, TRG20, L6, mediator complex subunit 10
External IDs OMIM: 612382 MGI: 106331 HomoloGene: 44533 GeneCards: MED10
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032286

NM_138596
NM_001378925

RefSeq (protein)

NP_115662

NP_613062
NP_001365854

Location (UCSC) Chr 5: 6.37 – 6.38 Mb Chr 13: 69.8 – 69.82 Mb
PubMed search [3] [4]
Wikidata
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Mediator complex subunit 10 (Med10) is a protein that in humans is encoded by the MED10 gene. [5]

Contents

Function

Med10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II. [6] [supplied by OMIM, Oct 2008].

See also

Related Research Articles

MED21

Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.

MED6

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.

MED4

Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of Mediator or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene.

MED31

Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene. It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.

MED22

Mediator of RNA polymerase II transcription subunit 22 is an enzyme that in humans is encoded by the MED22 gene.

MED7

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.

MED30

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene. It represents subunit Med30 of the Mediator complex and is metazoan-specific, having no homologues in yeasts.

USP47

Ubiquitin carboxyl-terminal hydrolase 47 is an enzyme that in humans is encoded by the USP47 gene.

MED28

Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene. It forms part of the Mediator complex.

MED8

Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.

MED27

Mediator of RNA polymerase II transcription subunit 27 is an enzyme that in humans is encoded by the MED27 gene. It forms part of the Mediator complex.

MED16

Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.

MED13

Mediator complex subunit 13 is a protein that in humans is encoded by the MED13 gene.

INTS1

Integrator complex subunit 1 is a protein that in humans is encoded by the INTS1 gene.

Integrator complex subunit 5

Integrator complex subunit 5 is a protein that in humans is encoded by the INTS5 gene.

MED9

Mediator complex subunit 9 (Med9) is a protein that in humans is encoded by the MED9 gene.

MED11

Mediator complex subunit 11 (Med11) is a protein that in humans is encoded by the MED11 gene.

MED18

Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.

MED19

Mediator complex subunit 19 (Med19) is a protein that in humans is encoded by the MED19 gene.

MED12L

Mediator complex subunit 12 like (Med12L) is a protein that in humans is encoded by the MED12L gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000133398 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021598 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Mediator complex subunit 10".
  6. Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. American Society for Biochemistry & Molecular Biology (ASBMB). 278 (17): 15123–7. doi: 10.1074/jbc.c300054200 . PMID   12584197.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.