MED7

Last updated
MED7
Identifiers
Aliases MED7 , ARC34, CRSP33, CRSP9, mediator complex subunit 7
External IDs OMIM: 605045 MGI: 1913463 HomoloGene: 3153 GeneCards: MED7
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004270
NM_001100816

NM_001104530
NM_001104556
NM_001104557
NM_025426

RefSeq (protein)

NP_001094286
NP_004261

NP_001098000
NP_001098026
NP_001098027
NP_079702

Location (UCSC) Chr 5: 157.14 – 157.16 Mb Chr 11: 46.33 – 46.33 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene. [5] [6]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [6]

Related Research Articles

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<span class="mw-page-title-main">MED1</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene. MED1 functions as a nuclear receptor coactivator.

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<span class="mw-page-title-main">MED14</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 14 is an enzyme that in humans is encoded by the MED14 gene.

<span class="mw-page-title-main">MED24</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 24 is an enzyme that in humans is encoded by the MED24 gene.

<span class="mw-page-title-main">MED21</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.

<span class="mw-page-title-main">CRSP3</span>

Mediator of RNA polymerase II transcription subunit 23 is an enzyme that in humans is encoded by the MED23 gene.

<span class="mw-page-title-main">MED6</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.

<span class="mw-page-title-main">MED4</span>

Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of Mediator or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene.

<span class="mw-page-title-main">MED17</span>

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.

<span class="mw-page-title-main">MED31</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene. It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.

<span class="mw-page-title-main">MED30</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene. It represents subunit Med30 of the Mediator complex and is metazoan-specific, having no homologues in yeasts.

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<span class="mw-page-title-main">MED25</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.

<span class="mw-page-title-main">MED8</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.

<span class="mw-page-title-main">MED27</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 27 is an enzyme that in humans is encoded by the MED27 gene. It forms part of the Mediator complex.

<span class="mw-page-title-main">MED16</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.

<span class="mw-page-title-main">MED26</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 26 is an enzyme that in humans is encoded by the MED26 gene. It forms part of the Mediator complex.

<span class="mw-page-title-main">MED13</span> Protein-coding gene in the species Homo sapiens

Mediator complex subunit 13 is a protein that in humans is encoded by the MED13 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000155868 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020397 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. Bibcode:1999Natur.397..446R. doi:10.1038/17141. hdl: 11858/00-001M-0000-0019-A36A-8 . PMID   9989412. S2CID   4405569.
  6. 1 2 "Entrez Gene: CRSP9 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa".

Further reading