MMS19

MMS19
Identifiers
Aliases	MMS19 , MET18, MMS19L, hMMS19 homolog, cytosolic iron-sulfur assembly component, CIAO4
External IDs	OMIM: 614777 MGI: 1919449 HomoloGene: 41480 GeneCards: MMS19
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.1 Start 97,458,324 bp [1] End 97,498,794 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 C3 Start 41,929,525 bp [2] End 41,969,596 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary skin of abdomen tibial nerve ganglionic eminence right lung canal of the cervix right lobe of thyroid gland sural nerve right uterine tube left lobe of thyroid gland Top expressed in superior frontal gyrus thymus lip oocyte secondary oocyte Ankle joint spermatocyte yolk sac ganglionic eminence morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity transcription coactivator activity protein binding enzyme binding signaling receptor complex adaptor activity estrogen receptor binding Cellular component membrane nucleoplasm transcription factor TFIIH holo complex CIA complex cytoskeleton MMXD complex nucleus cytoplasm spindle cytosol Biological process regulation of transcription, DNA-templated chromosome segregation DNA metabolic process cellular response to DNA damage stimulus positive regulation of transcription, DNA-templated iron-sulfur cluster assembly phosphorelay signal transduction system response to hormone DNA repair nucleotide-excision repair transcription, DNA-templated protein maturation by iron-sulfur cluster transfer positive regulation of double-strand break repair via homologous recombination positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64210 72199 Ensembl ENSG00000155229 ENSMUSG00000025159 UniProt Q96T76 Q9D071 RefSeq (mRNA) NM_001289403 NM_001289404 NM_001289405 NM_022362 NM_001330128 NM_001351356 NM_001351357 NM_001351358 NM_001351359 NM_028152 NM_001373946 RefSeq (protein) NP_001276332 NP_001276333 NP_001276334 NP_001317057 NP_071757 NP_001338285 NP_001338286 NP_001338287 NP_001338288 NP_082428 NP_001360875 Location (UCSC) Chr 10: 97.46 – 97.5 Mb Chr 19: 41.93 – 41.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MMS19 nucleotide excision repair protein homolog is a protein that in humans is encoded by the MMS19 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000155229 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025159 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seroz T, Winkler GS, Auriol J, Verhage RA, Vermeulen W, Smit B, Brouwer J, Eker AP, Weeda G, Egly JM, Hoeijmakers JH (Nov 2000). "Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases". Nucleic Acids Res. 28 (22): 4506–13. doi:10.1093/nar/28.22.4506. PMC   113875 . PMID   11071939.
6. "Entrez Gene: MMS19L MMS19-like (MET18 homolog, S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Wu X, Li H, Chen JD (2001). "The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor". J. Biol. Chem. 276 (26): 23962–8. doi: 10.1074/jbc.M101041200 . PMID   11279242.
• Queimado L, Rao M, Schultz RA, et al. (2002). "Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant". Nucleic Acids Res. 29 (9): 1884–91. doi:10.1093/nar/29.9.1884. PMC   37259 . PMID   11328871.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hatfield MD, Reis AM, Obeso D, et al. (2006). "Identification of MMS19 domains with distinct functions in NER and transcription". DNA Repair (Amst.). 5 (8): 914–24. doi:10.1016/j.dnarep.2006.05.007. PMID   16797255.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.