Margaret Goodell

Last updated

Margaret A. Goodell
Margaret Goodell 2.jpg
Education
Known forStem Cell Research
Children3
Scientific career
FieldsStem Cells, Cancer Biology
Institutions
Website https://www.goodell-lab.com

Margaret ("Peggy") A. Goodell (born March 23, 1965) is an American scientist working in the field of stem cell research. Dr. Goodell is Chair of the Department of Molecular and Cellular Biology [1] at Baylor College of Medicine, Director of the Stem Cell and Regenerative Medicine (STaR) Center, [2] and a member of the National Academy of Medicine. [3] She is best known for her discovery of a novel method to isolate adult stem cells. [4]

Contents

Goodell has been on the faculty of Baylor College of Medicine since 1997 as a member of the Center for Cell and Gene Therapy, and the Departments of Pediatrics, Molecular and Human Genetic, and Immunology. [5] She holds the Vivian L. Smith Chair in Regenerative Medicine, and has received numerous awards for excellence in teaching and research. [6] [7]

Goodell is Chair of the Scientific Advisory Board of the Keystone Symposia, a former President of the International Society for Experimental Hematology, and has served on the board of the International Society for Stem Cell Research. She has also served as the chair of the Stem Cells and Regenerative Medicine committee for the American Society of Hematology. She is an Associate Editor for Blood [8] and serves on the editorial boards of Cell Stem Cell and Cancer Cell .

Education

Goodell received her B.Sc. at Imperial College of Science and Technology in London, England in 1986 with Honors. She went on to earn her Ph.D. at University of Cambridge in 1991. She completed postdoctoral fellowships in Richard Mulligan’s lab at the prestigious Whitehead Institute for Biomedical Research at Massachusetts Institute of Technology and Harvard Medical School. [9]

At MIT, she developed a novel method for isolating blood-forming stem cells from mouse bone marrow based on a fortuitous observation that stem cells efflux fluorescent lipophilic dyes. This "side population (SP)" method has become widely used to isolate stem cells from a variety of species and adult tissues, including from cancer stem cells.[ citation needed ]

Research

In 1997, Goodell joined the faculty of the Department of Pediatrics, Molecular and Human Genetics, and Immunology at Baylor College of Medicine in Houston, TX. She is a member of the Center for Cell and Gene Therapy [10] and a founding member and director of the Stem Cell and Regenerative Medicine (STaR) Center. [11]

Her current research is focused on the mechanisms that regulate hematopoietic stem cells (HSC), and how those regulatory mechanisms go awry in hematologic malignancies. The Goodell Laboratory, which has about 15 students and post-doctoral fellows, studies the effects of stresses, including infection, toxicity, and age, on the behavior of HSCs. The lab also looks at stem cell growth control, as well as the regulation of self-renewal and activation. [12]

She has recently uncovered how the de novo DNA methyltransferase, DNMT3A — one of the most important tumor suppressors in the blood — contributes to stem cell self-renewal and differentiation in aging, inflammation, and cancer. [13] These interests led her to develop new tools to examine the epigenetic regulation in stem cells, including whole-genome methylation profiling, ChIP sequencing, RNA-seq, as well as a suite of novel CRISPR-mediated techniques to investigate the relationship between DNA methylation and gene expression. [14]

More than 400 of her peer-reviewed primary research papers have been published in journals including Nature [15] and Blood. [16]

Awards and honors

In 2004 and 2010, she received the DeBakey Award for Excellence in Research. In 2006, she was honored with the Stohlman Scholar Award from the Leukemia and Lymphoma Society, and from 2006 to 2011, she received the American Heart Association’s Established Investigator Award. In 2011, she was recognized with the Edith and Peter O’Donnell Award in Medicine, and in 2012, she was awarded the Damashek Prize from the American Society of Hematology

Her remarkable achievements continued with the 2019 National Academy of Medicine Award, the 2020 Tobias Lecture Award from the ISSCR, and the 2023 Donald Metcalf Award from the ISEH, [17] cementing her legacy as a distinguished figure in the field. Alongside these accomplishments, she received numerous accolades for her teaching and mentorship. Throughout her career, she mentored more than doctoral students and post-doctoral fellows, many of whom have gone on to successful careers in academia.

Biography

Goodell grew up in Bryan, Ohio with sisters Marian (a founding member and CEO of the Burning Man Project [18] ), Martha (a management consultant), and Melly (a physician). She is the daughter of Joe Goodell, former CEO of American Brass Company, and niece of Grace Goodell, professor of International Development at The Johns Hopkins School of Advanced International Studies. She lives in Houston, Texas with her husband and three daughters.

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A side population (SP) in flow cytometry is a sub-population of cells that is distinct from the main population on the basis of the markers employed. By definition, cells in a side population have distinguishing biological characteristics, but the exact nature of this distinction depends on the markers used in identifying the side population.

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References

  1. ↑ "Dr. Peggy Goodell named chair of cell biology". Baylor College of Medicine. August 27, 2019.
  2. ↑ "STaR Center". Baylor College of Medicine. Retrieved October 26, 2023.
  3. ↑ "National Academy of Medicine Elects 100 New Members". October 21, 2019.
  4. ↑ "ASH honors Margaret A. Goodell, Ph.D., with 2012 William Dameshek Prize". EurekAlert!.
  5. ↑ "Molecular and Human Genetics". Baylor College of Medicine.
  6. ↑ "2011 O'Donnell Awards Recipients - TAMEST (The Academy of Medicine, Engineering and Science of Texas)". TAMEST The Academy of Medicine, Engineering and Science of Texas.
  7. ↑ Lako, Majlinda; Daher, Susan (June 2009). "Balancing Work and Life: A Conversation with Margaret 'Peggy' Goodell". Stem Cells. 27 (6): 1227–1228. doi: 10.1002/stem.105 . PMID   19489078.
  8. ↑ "Editorial Board and Staff – Associate Editors". Blood. Archived from the original on June 18, 2014.
  9. ↑ "Hematopoietic Stem Cell Biology - Goodell Lab - Baylor College of Medicine, Houston, Texas". www.bcm.edu. Archived from the original on July 15, 2014. Retrieved January 14, 2022.
  10. ↑ "Margaret A. Goodell, Ph.D. - Center for Cell and Gene Therapy - Baylo…". Archived from the original on June 18, 2014.
  11. ↑ "STaR Center". Baylor College of Medicine. Retrieved October 26, 2023.
  12. ↑ "PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy" – via www.youtube.com.
  13. ↑ Goodell, Margaret A.; Li, Wei; Godley, Lucy A.; Issa, Jean-Pierre J.; Meissner, Alexander; Darlington, Gretchen J.; Lu, Yue; Liang, Shoudan; Gu, Hongcang; Vasanthakumar, Aparna; Bock, Christoph; Berg, Jonathan S.; Jelinek, Jaroslav; Luo, Min; Jeong, Mira; Sun, Deqiang; Challen, Grant A. (January 2012). "Dnmt3a is essential for hematopoietic stem cell differentiation". Nature Genetics. 44 (1): 23–31. doi:10.1038/ng.1009. PMC   3637952 . PMID   22138693.
  14. ↑ Gundry, Michael C.; Brunetti, Lorenzo; Lin, Angelique; Mayle, Allison E.; Kitano, Ayumi; Wagner, Dimitrios; Hsu, Joanne I.; Hoegenauer, Kevin A.; Rooney, Cliona M.; Goodell, Margaret A.; Nakada, Daisuke (October 2016). "Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9". Cell Reports. 17 (5): 1453–1461. doi:10.1016/j.celrep.2016.09.092. PMC   5087995 . PMID   27783956.
  15. ↑ Johnson, R. Paul; Mulligan, Richard C.; Sieff, Colin A.; Grupp, Stephen A.; DeMaria, MaryAnn; Marks, Douglas F.; Kim, Hyung; Rosenzweig, Michael; Goodell, Margaret A. (December 1997). "Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species". Nature Medicine. 3 (12): 1337–1345. doi:10.1038/nm1297-1337. PMID   9396603. S2CID   22879109.
  16. ↑ Search Results for author Goodell MA on PubMed .
  17. ↑ "Awards - International Society for Experimental Hematology". www.iseh.org. Retrieved October 26, 2023.
  18. ↑ "Marian Goodell". Burning Man Journal. June 21, 2019.
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