Max Perutz Labs

Last updated
Max Perutz Labs Vienna
MPL-Logo-RGB-Blau-2019-05-24.jpg
Parent institution University of Vienna
Medical University of Vienna
Established2005
Scientific directorAlwin Köhler
Location
Dr. Bohr-Gasse 9
1030 Vienna
Austria
Website maxperutzlabs.ac.at

The Max Perutz Labs Vienna are a molecular biology research centre operated jointly by the University of Vienna and the Medical University of Vienna [1] located at the Vienna Biocenter. The institute is named after the Viennese-born biochemist and Nobel laureate Max Ferdinand Perutz. On average, the institute hosts 50 independent research groups. Max Perutz Labs scientists participate in the undergraduate curricula for students of the University of Vienna and the Medical University of Vienna.

Contents

The main building MFPL building.jpg
The main building

History

The Max Perutz Labs Vienna were founded in 2005, named after the Viennese-born biochemist Max Ferdinand Perutz, who emigrated to England after graduating in Chemistry from the University of Vienna. In Cambridge, he helped to set up the Laboratory of Molecular Biology. He was awarded the Nobel prize in Chemistry together with John Kendrew in 1962, for their studies of the structures of globular proteins. [2]

Awards and honours

Max Perutz Labs former group leader Emmanuelle Charpentier received the 2015 Breakthrough Prize in Life Sciences and the 2020 Nobel Prize in Chemistry for her work on the CRISPR/Cas9 system, done partly in Vienna. [3] [4] [5] [6] [7]

As of June 2019, scientists of the Max Perutz Labs have been awarded 14 ERC grants. [2] [8] [9] [10] [11] [12]

Related Research Articles

Max Perutz Austrian-born British molecular biologist

Max Ferdinand Perutz was an Austrian-born British molecular biologist, who shared the 1962 Nobel Prize for Chemistry with John Kendrew, for their studies of the structures of haemoglobin and myoglobin. He went on to win the Royal Medal of the Royal Society in 1971 and the Copley Medal in 1979. At Cambridge he founded and chaired (1962–79) The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB), fourteen of whose scientists have won Nobel Prizes. Perutz's contributions to molecular biology in Cambridge are documented in The History of the University of Cambridge: Volume 4 published by the Cambridge University Press in 1992.

John Kendrew English biochemist and crystallographer

Sir John Cowdery Kendrew, was an English biochemist, crystallographer, and science administrator. Kendrew shared the 1962 Nobel Prize in Chemistry with Max Perutz, for their work at the Cavendish Laboratory to investigate the structure of heme-containing proteins.

MRC Laboratory of Molecular Biology Research institute in Cambridge, England

The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical research laboratory at the forefront of scientific discovery, dedicated to improving the understanding of key biological processes at atomic, molecular and cellular levels using multidisciplinary methods, with a focus on using this knowledge to address key issues in human health.

Franz-Ulrich Hartl is a German biochemist and Managing Director of the Max Planck Institute of Biochemistry. He is known for his pioneering work in the field of protein-mediated protein folding and is a recipient of the 2011 Lasker Award along with Arthur L. Horwich.

Research Institute of Molecular Pathology

The Research Institute of Molecular Pathology (IMP) is a biomedical research center, which conducts curiosity-driven basic research in the molecular life sciences.

Michael Marletta American biochemist

Michael A. Marletta is an American biochemist.

Jennifer Doudna American biochemist, professor, Nobel Prize in Chemistry winner 2020

Jennifer Anne Doudna is an American biochemist who has done pioneering work in CRISPR gene editing, and made other fundamental contributions in biochemistry and genetics. She received the 2020 Nobel Prize in Chemistry, with Emmanuelle Charpentier, "for the development of a method for genome editing." She is the Li Ka Shing Chancellor's Chair Professor in the Department of Chemistry and the Department of Molecular and Cell Biology at the University of California, Berkeley. She has been an investigator with the Howard Hughes Medical Institute since 1997.

Feng Zhang Chinese-American biochemist

Feng Zhang is a Chinese-American biochemist. Zhang currently holds the James and Patricia Poitras Professorship in Neuroscience at the McGovern Institute for Brain Research and in the departments of Brain and Cognitive Sciences and Biological Engineering at the Massachusetts Institute of Technology. He also has appointments with the Broad Institute of MIT and Harvard. He is most well known for his central role in the development of optogenetics and CRISPR technologies.

The Otto Warburg Medal is awarded annually by the German Society for Biochemistry and Molecular Biology to honour scientists who have contributed important work in the field of biological chemistry. It is named after Otto Warburg, a renowned German physiologist and Nobel Prize laureate. It was first awarded on his 80th birthday on 8 October 1963.

Women in chemistry

This is a list of women chemists. It should include those who have been important to the development or practice of chemistry. Their research or application has made significant contributions in the area of basic or applied chemistry.

Emmanuelle Charpentier French microbiologist and biochemist

Emmanuelle Marie Charpentier is a French professor and researcher in microbiology, genetics, and biochemistry. Since 2015, she has been a Director at the Max Planck Institute for Infection Biology in Berlin. In 2018, she founded an independent research institute, the Max Planck Unit for the Science of Pathogens. In 2020, Charpentier and American biochemist Jennifer Doudna of the University of California, Berkeley, were awarded the Nobel Prize in Chemistry "for the development of a method for genome editing". This was the first science Nobel ever won by two women alone.

Virginijus Šikšnys Lithuanian biochemist

Virginijus Šikšnys is a Lithuanian biochemist and a professor at Vilnius University. He is a chief scientist at the Vilnius University Institute of Biotechnology.

Vienna Biocenter Group of life science research institutes in Vienna, Austria

The Vienna BioCenter is a cluster of life science research institutes and biotechnology companies located in the 3rd municipal District of Vienna, Austria. It grew around the Research Institute of Molecular Pathology (IMP), which opened in 1988. The entities at the Vienna BioCenter employ more than 2,000 people, including 600 students.

Erwin Friedrich Wagner Austrian biochemist (born 1950)

Erwin Friedrich Wagner is an Austrian biochemist known for his research on the molecular basis of cancer and associated conditions such as inflammation and cachexia. He was Deputy Director of the Spanish National Cancer Research Center (CNIO) in Madrid, Spain until 2019. Since 2019, Wagner is a group leader affiliated with the Medical University of Vienna.

Arndt von Haeseler is a German bioinformatician and evolutionary biologist. He is the scientific director of the Max F. Perutz Laboratories at the Vienna Biocenter and a professor of bioinformatics at the University of Vienna and the Medical University of Vienna.

Sarah E. O'Connor is an American molecular biologist working to understand the molecular machinery involved in assembling important plant natural products - vinblastine, morphine, iridoids, secologanin - and how changing the enzymes involved in this pathway lead to diverse analogs. She was a Project Leader at the John Innes Centre in the UK between 2011 and 2018. O'Connor was appointed by the Max Planck Society in 2018 to head the Department of Natural Product Biosynthesis at the Max Planck Institute for Chemical Ecology in Jena, Germany, taking up her role during 2019.

CRISPR gene editing Gene editing method

CRISPR gene editing is a genetic engineering technique in molecular biology by which the genomes of living organisms may be modified. It is based on a simplified version of the bacterial CRISPR-Cas9 antiviral defense system. By delivering the Cas9 nuclease complexed with a synthetic guide RNA (gRNA) into a cell, the cell's genome can be cut at a desired location, allowing existing genes to be removed and/or new ones added in vivo.

Luciano Marraffini American Microbiologist

Luciano Marraffini is an Argentinian-American microbiologist. He is currently professor and head of the laboratory of bacteriology at The Rockefeller University. He is recognized for his work on CRISPR-Cas systems, being one of the first scientists to elucidate how these systems work at the molecular level.

References

  1. Vienna, Medical University of. "Kooperationen". Medical University of Vienna. Retrieved 2018-02-17.
  2. 1 2 "MFPL History". Home. Retrieved 2018-02-18.
  3. Abbott, Alison (2016-04-27). "The quiet revolutionary: How the co-discovery of CRISPR explosively changed Emmanuelle Charpentier's life". Nature. Springer Nature. 532 (7600): 432–434. doi: 10.1038/532432a . ISSN   0028-0836. PMID   27121823.
  4. "Genetik-Revolution: Emmanuelle Charpentier, die Frau mit den DNA-Scheren". derStandard.at (in German). 2015-12-31. Retrieved 2018-02-18.
  5. "Breakthrough Prize for Emmanuelle Charpentier". MFPL. Retrieved 2018-02-18.
  6. Jinek, Martin; Chylinski, Krzysztof; Fonfara, Ines; Hauer, Michael; Doudna, Jennifer A.; Charpentier, Emmanuelle (2012-06-28). "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity". Science. 337 (6096): 816–821. doi:10.1126/science.1225829. ISSN   0036-8075. PMC   6286148 . PMID   22745249.
  7. "The Nobel Prize in Chemistry 2020". The Nobel Prize. Retrieved 2020-10-08.
  8. "Two ERC Consolidator Grants for the MFPL". Home. Retrieved 2018-02-18.
  9. "Max Perutz Labs at a glance". Max Perutz Labs. Retrieved 2019-06-17.
  10. ""Max Perutz Labs at a glance"" . Retrieved 2022-03-09.
  11. "ERC grant for Thomas Juffmann". 2022-02-22. Retrieved 2022-03-09.
  12. "Exploring the molecular basis of heredity: ERC grant for Joao Matos". 2020-12-09. Retrieved 2022-03-09.

Coordinates: 48°11′18″N16°24′04″E / 48.1883°N 16.4010°E / 48.1883; 16.4010