Memory disorder

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Memory disorders are the result of damage to neuroanatomical structures that hinders the storage, retention and recollection of memories. Memory disorders can be progressive, including Alzheimer's disease, or they can be immediate including disorders resulting from head injury.

Contents

In alphabetical order

Acquired brain injury (ABI)

Agnosia

Agnosia is the inability to recognize certain objects, persons or sounds. Agnosia is typically caused by damage to the brain (most commonly in the occipital or parietal lobes) or from a neurological disorder. Treatments vary depending on the location and cause of the damage. Recovery is possible depending on the severity of the disorder and the severity of the damage to the brain. [1] Many more specific types of agnosia diagnoses exist, including: associative visual agnosia, astereognosis, auditory agnosia, auditory verbal agnosia, prosopagnosia, simultanagnosia, topographical disorientation, visual agnosia etc.

Alzheimer's disease

Alzheimer's disease (AD) is a progressive, degenerative and fatal brain disease, in which cell to cell connections in the brain are lost. Alzheimer's disease is the most common form of dementia. [2] Globally approximately 1–5% of the population is affected by Alzheimer's disease. [3] Women are disproportionately affected by Alzheimer's disease. The evidence suggests that women with AD display more severe cognitive impairment relative to age-matched males with AD, as well as a more rapid rate of cognitive decline. [4]

Amnesia

Amnesia is an abnormal mental state in which memory and learning are affected out of all proportion to other cognitive functions in an otherwise alert and responsive patient. [5] There are two forms of amnesia: Anterograde amnesia and retrograde amnesia, that show hippocampal or medial temporal lobe damage. People with anterograde amnesia show difficulty in the learning and retention of information encountered after brain damage. People with retrograde amnesia generally have memories spared about personal experiences or context independent semantic information. [6]

Brain injury

Causes of TBI TBI causes chart.svg
Causes of TBI

Traumatic brain injury (TBI) often occurs from damage to the brain caused by an outside force, and may lead to cases of amnesia depending on the severity of the injury. [8] Head injury can give rise to either transient or persisting amnesia. Occasionally, post-traumatic amnesia (PTA) may exist without any retrograde amnesia (RA), but this is often more common in cases of penetrating lesions. Damage to the frontal or anterior temporal regions have been described to be associated with disproportionate RA. Studies have illustrated that during PTA, head injury patients showed accelerated forgetting of learned information. On the other hand, after PTA, forgetting rates were normal. [8]

As noted in the above-mentioned section on traumatic brain injury it can be associated with memory impairment, Alzheimer's disease; however, as far as aging is concerned it poses other threats as well. There is evidence that supports a high incidence of falls among the elderly population and this is a leading cause of TBI-associated death among the population of people 75 years of age and older. [9] When looking at the chart to the right on the page, it states that falls are only 28% of the total causes of TBI, so that would suggest that the elderly make up a good portion of that 28% overall. Another factor associated with TBI and age is the relationship between when the injury was sustained and the age at which it occurred. It is estimated that the older the individual, the more likely they would require assistance post TBI. [9]

In some cases, individuals have reported having a particularly vivid memory for images or sounds occurring immediately before the injury, on regaining consciousness, or during a lucid interval between the injury and the onset of PTA. As a result, recent controversy has emerged about whether severe head injury and amnesia exclude the possibility of post-traumatic stress disorder (PTSD) symptoms. In a study carried out by McMillan (1996), patients reported ‘windows' of experience, in which emotional disturbance was sufficient to cause PTSD. These 'windows' involved recall of events close to impact (when RA was brief), of distressing events soon after the accident (when PTA was short), or of 'islands' of memory (e.g. hearing the screaming of others). [5] [10]

Brain injuries can also be the result of a stroke as the resulting lack of oxygen can cause damage to the location of the cerebrovascular accident (CVA). The effects of a CVA in the left and right hemispheres of the brain include short-term memory impairment, and difficulty acquiring and retaining new information. [11]

Dementia

Dementia refers to a large class of disorders characterized by the progressive deterioration of thinking ability and memory as the brain becomes damaged. Dementia can be categorized as reversible (e.g. thyroid disease) or irreversible (e.g. Alzheimer's disease). [12] Currently, there are more than 35 million people with dementia worldwide. In the United States alone the number of people affected by dementia is striking at 3.8 million. [13]

While studies show that there are “normal” aspects to aging, such as graying hair and changes in vision, there are changes such as forgetting how to do things that are not considered “normal”. [13] The importance of understanding that the changes most frequently observed and noticed on a daily basis concerning aging loved ones is imperative. While mild cognitive impairment can be considered a normal part of aging, the differences must be noted.

In one study by J. Shagam, it was noted that while Diabetes and Hypertension are not considered part of normal aging, they would be classified under mild cognitive impairment. [13] With this being said, it is important to differentiate the differences with what can be potentially harmful and what is not. It is difficult to accurately diagnose dementia due to the fact that most people are unaware of what to be looking for and also because there is no specific test which can be given as a diagnostic tool. [13]

What is even more evident is that the symptoms among dementia, Alzheimer's and Parkinson's related dementia tend to go beyond just one ailment. [13] While there are different forms of dementia, Vascular dementia as it would sound is associated with vascular cautions. [14]

This form of dementia is not a slow deterioration but rather a sudden and unexpected change due to heart attack or stroke [15] significantly reducing blood to the brain. [14] Research has shown that persistent hypertension can be contributory to the breakdown of the BBB. [14] The blood-brain barrier (BBB) serves as a “gatekeeper” for the brain by keeping out water and other substances. Various studies show that as the brain ages the blood-brain barrier starts to break down and become dysfunctional. [14] There are different ways to measure the thinning of the BBB and one that most are familiar with is imaging, this consists of taking pictures of the brain using CT scans, MRI, or PET scans. [14]

Previous research also indicates that with aging and the thinning of the BBB, cognitive changes were also occurring within the section of the brain known as the hippocampus. This shows a relationship between aging and the thinning of the BBB and its effects on the brain. Also indicated by the aging brain are learning and memory impairments. [14]

While changes to the BBB are not a cause of impairment to cognitive functions alone research suggests that there is a relationship. Another impairment which is indicative of brain aging and the breakdown of the BBB is the accretion of iron. [14]

Too much iron in the body can create free radicals which could influence the degeneration of the blood-brain barrier. [14] One other specific age related factor noted in Popescu et al. is a decrease in estrogen as one ages could adversely affect the breakdown of the blood-brain barrier and create a sensitivity to neurodegeneration. [14] As pointed out earlier, dementia is a broad category of memory impairments most commonly associated with ageing. Another symptom which should be monitored is Type 2 diabetes, which can lead to vascular dementia. [14]

Also linked with vascular dementia issues is high cholesterol; furthermore, this risk factor is related to cognitive decline, stroke, and Alzheimer's disease. [14] It is estimated that within 20 years, worldwide prevalence will increase twofold. By 2050, this number is expected to increase to 115 million. Overall, dementia incidence is similar for men and women. However, after 90 years of age dementia incidence declines in men but not in women. [16]

Hyperthymestic syndrome

Hyperthymestic syndrome causes an individual to have an extremely detailed autobiographical memory. Patients with this condition are able to recall events from every day of their lives (with the exception of memories before age five and days that were uneventful). This condition is very rare with only a few confirmed cases. [17] [18]

Huntington's disease

Huntington's disease (HD) is an inherited progressive disorder of the brain that leads to uncontrolled movements, emotional instability, and loss of intellectual faculties. [19] Because of the inheritability of Huntington's each child born to a parent with Huntington's has a 50% chance of inheriting the disease, leading to a prevalence of almost 1 in 10,000 Canadians (0.01%). [20]

The first signs of Huntington's Disease are generally subtle; those affected commonly note tics and twitching as well as unexplained fluctuations of mood. Clumsiness, depression and irritability are noted. What begins as a slurring and slowing of speech eventually leads to difficulty communicating, reliance on a wheelchair, or confinement to a bed. [19]

Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative disease. PD and aging share a lot of the same neuropathologic and behavioral features. [21] Movement is normally controlled by dopamine; a chemical that carries signals between the nerves in the brain. When cells that normally produce dopamine die off, the symptoms of Parkinson's appear. This degeneration also occurs in normal aging but is a much slower process. [21] The most common symptoms include: tremors, slowness, stiffness, impaired balance, rigidity of the muscles, and fatigue. As the disease progresses, non-motor symptoms may also appear, such as depression, difficulty swallowing, sexual problems or cognitive changes. [22]

Another symptom associated with PD is memory dysfunction. This can be attributed to frontal lobe damage and presents itself in a manner which could be associated in normal aging. However, there is no certain correlation between normal aging and that of Parkinson's disease with relation to memory specifically. [21] According to studies done in London and in Sicily, 1 in 1000 elderly citizens will be diagnosed with Parkinson's, [23] although this can vary regionally and affect a large range of age groups. [24]

Cognitive impairment is common in PD. Specific parkinsonian symptoms, bradykinesia and rigidity, have been shown to be associated with decline of cognitive function. The underlying neuropathological disturbance in PD involves selective deterioration of subcortical structures, and the executive dysfunction in PD, especially in processes that involve working memory. This has been shown to be related to decreased activation in the basal ganglia and frontal cortex. Elgh, Domellof, Linder, Edstrom, Stenlund, & Forsgren (2009) studied cognitive function in early Parkinson's disease and found that PD patients performed significantly worse than healthy controls in attention, episodic memory, category fluency, psychomotor function, visuospatial function and in several measures of executive function. Patients also exhibited greater difficulty with free recall that required a preserved executive function than with cued recall and recognition in tests of episodic memory. [25]

According to a Japanese study, normal elderly subjects had difficulty with memory recognition and the PD elderly subjects had an even more troubling time with recognition than the normal group Another pertinent correlation made by this Japanese survey is that for PD patients their immediate memory response is intact while their ability to recognize memories from the past are inhibited. It is also said that PD patient memory is considered a selective impairment. [21]

Stress

It has become clear that aging negatively affects brain function and this can encompass a decrease in locomotor activities and coordination as well as affect in a negative way learning and memory. [26] Certain responses to stress within the hippocampus can have negative effects on learning. [26] In a study done by Mark A. Smith, it is demonstrated that exposure to continuous stress can cause age-related issues to the hippocampus. [27] What then becomes more noticeable is that the aging brain is not as able to recognize growth, this is a symptom of hippocampal damage. If the information is not being encoded properly in the brain then of course there would not be good memory retention without the consideration of outside implications. However, the consideration of anxiety, memory and overall function must be compromised. An emotional memory is capable of being embedded and then reused in a similar scenario at a later time if need be. [27] Also noted within a study relating to age and anxiety and memory it was noted that lesions on the brain can affect spatial learning as well as sex presenting at a disadvantage. Dysfunction within the hippocampus can be a reason behind aging brain changes among the elderly. [27] To sum up anxiety and memory and aging, it is useful to recognize a correlation between what anxiety can cause the body to do and how memories are then formed or not formed, and how the aging brain has enough difficulty on its own trying to perform recall tasks.

Wernicke–Korsakoff syndrome

Wernicke–Korsakoff syndrome (WKS) is a severe neurological disorder caused by thiamine (vitamin B1) deficiency, and is usually associated with chronic excessive alcohol consumption. It is characterized clinically by oculomotor abnormalities, cerebellar dysfunction and an altered mental state. Korsakoff's syndrome is also characterized by profound amnesia, disorientation and frequent confabulation (making up or inventing information to compensate for poor memory). [28] [29] A survey published in 1995 indicated that there was no connection to the national average amount of alcohol ingested by a country in correlation to a range of prevalence within 0 and 2.5%. [30]

Symptoms of Wernicke–Korsakoff syndrome include confusion, amnesia, and impaired short-term memory. WKS also tends to impair the person's ability to learn new information or tasks. In addition, individuals often appear apathetic and inattentive and some may experience agitation. WKS symptoms may be long-lasting or permanent and its distinction is separate from acute effects of alcohol consumption and from periods of alcohol withdrawal. [28]

Case studies

A.J. had a rare memory disorder called hyperthymestic syndrome. She had an inability to forget. Her autobiographical memory was extremely accurate to the point that she remembered every day of her life in detail (with some exceptions). She was unable to control what she remembered or what she forgot. [18]

Clive Wearing had anterograde amnesia after a rare case of herpes simplex virus I (HSV-I) which targeted and attacked the spinal column and brain. The virus led to a case of encephalitis which caused the brain damage of his hippocampus, resulting in his amnesia. [31]

Molaison had epileptic seizures and had his medial temporal lobes surgically removed to prevent or decrease the occurrence of the seizures. After the removal of Molaison's medial temporal lobes, he had anterograde amnesia as well as moderate retrograde amnesia. Molaison was still able to retain procedural memory after the surgery. [32] [33]

"The extent of damage to K.C.'s medial temporal lobes, particularly to his hippocampus and parahippocampal gyrus, and associated diencephalic and basal forebrain structures, is in line with his profound impairment on all explicit tests of new learning and memory. There is some uncertainty as to whether this pattern of neurological damage also accounts for his severe remote autobiographical memory loss while sparing his remote spatial memory." [6]

Zasetsky was a patient who was treated by Russian neuropsychologist Alexander Luria [34]

Aging

Normal aging, although not responsible for causing memory disorders, is associated with a decline in cognitive and neural systems including memory (long-term and working memory). Many factors such as genetics and neural degeneration have a part in causing memory disorders. In order to diagnose Alzheimer's disease and dementia early, researchers are trying to find biological markers that can predict these diseases in younger adults. One such marker is a beta-amyloid deposit which is a protein that deposits on the brain as we age. Although 20-33% of healthy elderly adults have these deposits, they are increased in elderly with diagnosed Alzheimer's disease and dementia. [35]

Amyloid plaques associated with Alzheimer's disease that increase in number with age Alzheimer dementia (3) presenile onset.jpg
Amyloid plaques associated with Alzheimer's disease that increase in number with age

Additionally, traumatic brain injury, TBI, is increasingly being linked as a factor in early-onset Alzheimer's disease. [9]

The National Health and Nutrition Examination Survey (NHANES) administered the word learning and recall modules from the Consortium to Establish a Registry for Alzheimer's disease (CERAD) to over three thousand participants 60 years and older in 2011–2014. Trained interviewers administered the test at the end of a face-to-face private interview in an examination center. An extensive analysis of these data has been published. [36] Delayed recall scores (median, 25th percentile, 75th percentile) declined with age: 60-69y: 6.4, 4.9, 7.8; 70-79y: 5.5, 3.9, 7.0; 80+y: 4.1, 2.4, 5.8.

One study examined dementia severity in elderly schizophrenic patients diagnosed with Alzheimer's disease and dementia versus elderly schizophrenic patients without any neurodegenerative disorders. In most cases, if schizophrenia is diagnosed, Alzheimer's disease or some form of dementia in varying levels of severity is also diagnosed. It was found that increased hippocampal neurofibrillary tangles and higher amyloid plaque density (in the superior temporal gyrus, orbitofrontal gyrus, and the inferior parietal cortex) were associated with increased severity of dementia. Along with these biological factors, when the patient also had the apolipoprotein E (ApoE4) allele (a known genetic risk factor for Alzheimer's disease), the amyloid plaques increased although the hippocampal neurofibrillary tangles did not. It showed an increased genetic susceptibility to more severe dementia with Alzheimer's disease than without the genetic marker. [37]

As seen in the examples above, although memory does degenerate with age, it is not always classified as a memory disorder. The difference in memory between normal aging and a memory disorder is the amount of beta-amyloid deposits, hippocampal neurofibrillary tangles, or amyloid plaques in the cortex. If there is an increased amount, memory connections become blocked, memory functions decrease much more than what is normal for that age and a memory disorder is diagnosed. [35] [37]

The cholinergic hypothesis of geriatric memory dysfunction is an older hypothesis that was considered before beta-amyloid deposits, neurofibrillary tangles, or amyloid plaques. It states that by blocking the cholinergic mechanisms in control subjects you can examine the relationship between cholinergic dysfunction and normal aging and memory disorders because this system when dysfunctional creates memory deficits. [38]

Cultural perspectives

The pervasiveness of mental health illnesses can be illustrated by looking at the size of the Diagnostic and Statistical Manual IV-TR (DSM IV-TR). Epidemiological studies have shown an increase in mental health cases globally. In 2050, there could be a pandemic of neurological diseases. [39] An aging baby-boom population increases the demand for mental health care.

Western culture's gauge of mental illness is determinate on level of dangerousness, competence, and responsibility. [40] This has led to many individuals being denied jobs, [41] [42] [43] [44] less likely to be able to rent apartments, [45] [46] [47] and more likely to have false criminal charges pressed against them. [48] [49] The level of services available to an ever aging and memory-impaired demographic will need to increase in spite of the stigma against mental illness.

With such a stigmatization of memory disorders, and mental illnesses in general, it can be especially hard for those providing aid for these individuals. Some individuals “are unable to acquire or retain new information, making it difficult or impossible to meet social, family and work-related obligations.” [50] Because of this, there is a large responsibility placed on caregivers (usually children) [51] to uphold economic and emotional upkeeps. While there are services available for this group, very few make use of them. [52]

In Asian collectivist cultures, focus lies on the social interactions between members of society. Every individual in the society has a certain role to fulfill, and it is deemed socially acceptable to uphold these roles. Furthermore, there is a focus on a balance of body, mind, and spirit. As a result, there is a large discrepancy between what should be deemed acceptable treatments for memory disorders that focus on interpersonal relationships and adjustments to others' expectations rather than a Western-led treatment schedule.[ citation needed ]. In these Asian cultures, mental illness is believed to be the result of an imbalance of hot-cold/wet-dry which interferes with the proper functioning of the nerves, heart, liver, lungs, kidneys, and spleen. [53] Such an imbalance can sometimes been seen as a point of beauty as "one is the recipient of others' concern and sympathy." [53]

Characters with memory disorders have helped to move literature and media along by allowing for suspense to be created either through retrograde or traumatic amnesia as seen in Alfred Hitchcock's Spellbound . It can also provide comic relief if a character is introduced who has short-term memory impairments.

Some examples from movies and television that depict characters with memory disorders include:

See also

Related Research Articles

<span class="mw-page-title-main">Dementia</span> Long-term brain disorders causing impaired memory, thinking and behavior

Dementia is the general name for a decline in cognitive abilities that impacts a person's ability to perform everyday activities. This typically involves problems with memory, thinking, and behavior. Aside from memory impairment and a disruption in thought patterns, the most common symptoms include emotional problems, difficulties with language, and decreased motivation. The symptoms may be described as occurring in a continuum over several stages. Dementia ultimately has a significant effect on the individual, caregivers, and on social relationships in general. A diagnosis of dementia requires the observation of a change from a person's usual mental functioning and a greater cognitive decline than what is caused by normal aging.

<span class="mw-page-title-main">Dementia with Lewy bodies</span> Type of progressive dementia

Dementia with Lewy bodies (DLB) is a type of dementia characterized by changes in sleep, behavior, cognition, movement, and regulation of automatic bodily functions. Memory loss is not always an early symptom. The disease worsens over time and is usually diagnosed when cognitive impairment interferes with normal daily functioning. Together with Parkinson's disease dementia, DLB is one of the two Lewy body dementias. It is a common form of dementia, but the prevalence is not known accurately and many diagnoses are missed. The disease was first described by Kenji Kosaka in 1976.

Vascular dementia (VaD) is dementia caused by problems in the blood supply to the brain, resulting from a cerebrovascular disease. Restricted blood supply (ischemia) leads to cell and tissue death in the affected region, known as an infarct. The three types of vascular dementia are subcortical vascular dementia, multi-infarct dementia, and stroke related dementia. Subcortical vascular dementia is brought about by damage to the small blood vessels in the brain. Multi-infarct dementia is brought about by a series of mini-strokes where many regions have been affected. The third type is stroke related where more serious damage may result. Such damage leads to varying levels of cognitive decline. When caused by mini-strokes, the decline in cognition is gradual. When due to a stroke, the cognitive decline can be traced back to the event.

Cognitive disorders (CDs), also known as neurocognitive disorders (NCDs), are a category of mental health disorders that primarily affect cognitive abilities including learning, memory, perception, and problem-solving. Neurocognitive disorders include delirium, mild neurocognitive disorders, and major neurocognitive disorder. They are defined by deficits in cognitive ability that are acquired, typically represent decline, and may have an underlying brain pathology. The DSM-5 defines six key domains of cognitive function: executive function, learning and memory, perceptual-motor function, language, complex attention, and social cognition.

Cerebral atrophy is a common feature of many of the diseases that affect the brain. Atrophy of any tissue means a decrement in the size of the cell, which can be due to progressive loss of cytoplasmic proteins. In brain tissue, atrophy describes a loss of neurons and the connections between them. Brain atrophy can be classified into two main categories: generalized and focal atrophy. Generalized atrophy occurs across the entire brain whereas focal atrophy affects cells in a specific location. If the cerebral hemispheres are affected, conscious thought and voluntary processes may be impaired.

Mirrored-self misidentification is the delusional belief that one's reflection in the mirror is another person – typically a younger or second version of one's self, a stranger, or a relative. This delusion occurs most frequently in patients with dementia and an affected patient maintains the ability to recognize others' reflections in the mirror. It is caused by right hemisphere cranial dysfunction that results from traumatic brain injury, stroke, or general neurological illness. It is an example of a monothematic delusion, a condition in which all abnormal beliefs have one common theme, as opposed to a polythematic delusion, in which a variety of unrelated delusional beliefs exist. This delusion is also classified as one of the delusional misidentification syndromes (DMS). A patient with a DMS condition consistently misidentifies places, objects, persons, or events. DMS patients are not aware of their psychological condition, are resistant to correction and their conditions are associated with brain disease – particularly right hemisphere brain damage and dysfunction.

<span class="mw-page-title-main">Organic brain syndrome</span> Disorder of mental function whose cause is alleged to be known as physiological

Organic brain syndrome, also known as organic brain disease, organic brain damage, organic brain disorder, organic mental syndrome, or organic mental disorder, refers to any syndrome or disorder of mental function whose cause is alleged to be known as organic (physiologic) rather than purely of the mind. These names are older and nearly obsolete general terms from psychiatry, referring to many physical disorders that cause impaired mental function. They are meant to exclude psychiatric disorders. Originally, the term was created to distinguish physical causes of mental impairment from psychiatric disorders, but during the era when this distinction was drawn, not enough was known about brain science for this cause-based classification to be more than educated guesswork labeled with misplaced certainty, which is why it has been deemphasized in current medicine. While mental or behavioural abnormalities related to the dysfunction can be permanent, treating the disease early may prevent permanent damage in addition to fully restoring mental functions. An organic cause to brain dysfunction is suspected when there is no indication of a clearly defined psychiatric or "inorganic" cause, such as a mood disorder.

<span class="mw-page-title-main">Neurodegenerative disease</span> Central nervous system disease

A neurodegenerative disease is caused by the progressive loss of structure or function of neurons, in the process known as neurodegeneration. Such neuronal damage may ultimately involve cell death. Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system atrophy, tauopathies, and prion diseases. Neurodegeneration can be found in the brain at many different levels of neuronal circuitry, ranging from molecular to systemic. Because there is no known way to reverse the progressive degeneration of neurons, these diseases are considered to be incurable; however research has shown that the two major contributing factors to neurodegeneration are oxidative stress and inflammation. Biomedical research has revealed many similarities between these diseases at the subcellular level, including atypical protein assemblies and induced cell death. These similarities suggest that therapeutic advances against one neurodegenerative disease might ameliorate other diseases as well.

Cognitive impairment is an inclusive term to describe any characteristic that acts as a barrier to the cognition process or different areas of cognition. Cognition, also known as cognitive function, refers to the mental processes of how a person gains knowledge, uses existing knowledge, and understands things that are happening around them using their thoughts and senses. A cognitive impairment can be in different domains or aspects of a person's cognitive function including memory, attention span, planning, reasoning, decision-making, language, executive functioning, and visuospatial functioning. The term cognitive impairment covers many different diseases and conditions and may also be symptom or manifestation of a different underlying condition. Examples include impairments in overall intelligence ,specific and restricted impairments in cognitive abilities, neuropsychological impairments, or it may describe drug-induced impairment in cognition and memory. Cognitive impairments may be short-term, progressive or permanent.

Alcohol-related dementia (ARD) is a form of dementia caused by long-term, excessive consumption of alcohol, resulting in neurological damage and impaired cognitive function.

Mild cognitive impairment (MCI) is a neurocognitive disorder which involves cognitive impairments beyond those expected based on an individual's age and education but which are not significant enough to interfere with instrumental activities of daily living. MCI may occur as a transitional stage between normal aging and dementia, especially Alzheimer's disease. It includes both memory and non-memory impairments. The cause of the disorder remains unclear, as well as both its prevention and treatment, with some 50 percent of people diagnosed with it going on to develop Alzheimer's disease within five years. The diagnosis can also serve as an early indicator for other types of dementia, although MCI may remain stable or even remit.

<span class="mw-page-title-main">Bradyphrenia</span> Slow mental activity

Bradyphrenia is the slowness of thought common to many disorders of the brain. Disorders characterized by bradyphrenia include Parkinson's disease and forms of schizophrenia consequently causing a delayed response and fatigue. Patients with bradyphrenia may describe or may manifest slowed thought processes, evidenced by increased latency of response and also involve severe memory impairment and poor motor control. The word 'bradyphrenia' originates from the ancient Greek meaning 'slow mind.'

<span class="mw-page-title-main">Alzheimer's disease</span> Progressive neurodegenerative disease

Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, and is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems with language, disorientation, mood swings, loss of motivation, self-neglect, and behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the average life expectancy following diagnosis is three to twelve years.

Retrospective memory is the memory of people, words, and events encountered or experienced in the past. It includes all other types of memory including episodic, semantic and procedural. It can be either implicit or explicit. In contrast, prospective memory involves remembering something or remembering to do something after a delay, such as buying groceries on the way home from work. However, it is very closely linked to retrospective memory, since certain aspects of retrospective memory are required for prospective memory.

Subcortical dementias includes those diseases which predominantly affects the basal ganglia along with features of cognitive decline.

<span class="mw-page-title-main">Montreal Cognitive Assessment</span> Screening assessment for detecting cognitive impairment

The Montreal Cognitive Assessment (MoCA) is a widely used screening assessment for detecting cognitive impairment. It was created in 1996 by Ziad Nasreddine in Montreal, Quebec. It was validated in the setting of mild cognitive impairment (MCI), and has subsequently been adopted in numerous other clinical settings. This test consists of 30 points and takes 10 minutes for the individual to complete. The original English version is performed in seven steps, which may change in some countries dependent on education and culture. The basics of this test include short-term memory, executive function, attention, focus, and more.

<span class="mw-page-title-main">Type 3 diabetes</span> Medical condition

Type 3 diabetes is a proposed pathological linkage between Alzheimer's disease and certain features of type 1 and type 2 diabetes. Specifically, the term refers to a set of common biochemical and metabolic features seen in the brain in Alzheimer's disease, and in other tissues in diabetes; it may thus be considered a "brain-specific type of diabetes." It was recognized at least as early as 2005 that some features of brain function in Alzheimer's disease mimic those that underlie diabetes. However, the concept of type 3 diabetes is controversial, and as of 2021 it was not an officially recognized diagnosis.

Alzheimer's Disease Neuroimaging Initiative (ADNI) is a multisite study that aims to improve clinical trials for the prevention and treatment of Alzheimer's disease (AD). This cooperative study combines expertise and funding from the private and public sector to study subjects with AD, as well as those who may develop AD and controls with no signs of cognitive impairment. Researchers at 63 sites in the US and Canada track the progression of AD in the human brain with neuroimaging, biochemical, and genetic biological markers. This knowledge helps to find better clinical trials for the prevention and treatment of AD. ADNI has made a global impact, firstly by developing a set of standardized protocols to allow the comparison of results from multiple centers, and secondly by its data-sharing policy which makes available all at the data without embargo to qualified researchers worldwide. To date, over 1000 scientific publications have used ADNI data. A number of other initiatives related to AD and other diseases have been designed and implemented using ADNI as a model. ADNI has been running since 2004 and is currently funded until 2021.

There are a variety of disabilities affecting cognitive ability. This is a broad concept encompassing various intellectual or cognitive deficits, including intellectual disability, deficits too mild to properly qualify as intellectual disability, various specific conditions, and problems acquired later in life through acquired brain injuries or neurodegenerative diseases like dementia.

Visual selective attention is a brain function that controls the processing of retinal input based on whether it is relevant or important. It selects particular representations to enter perceptual awareness and therefore guide behaviour. Through this process, less relevant information is suppressed.

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