NDST1

NDST1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NST
Identifiers
Aliases	NDST1 , HSST, NST1, MRT46, N-deacetylase/N-sulfotransferase 1, N-deacetylase and N-sulfotransferase 1
External IDs	OMIM: 600853 MGI: 104719 HomoloGene: 20386 GeneCards: NDST1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,558,211 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	60,881,722 bp
RNA expression pattern
	Top expressed in
	Stromal cell of endometrium; ; olfactory bulb; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; right lobe of liver; ; inferior olivary nucleus; ; upper lobe of left lung; ; external globus pallidus; ; spleen; ; ventral tegmental area;
	Top expressed in
	right lung lobe; ; left lung; ; left lung lobe; ; lacrimal gland; ; Epithelium of stomach; ; left lobe of liver; ; salivary gland; ; vas deferens; ; digastric muscle; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; sulfotransferase activity ; deacetylase activity ; catalytic activity ; hydrolase activity ; N-acetylglucosamine deacetylase activity ; protein binding ; [heparan sulfate-glucosamine N-sulfotransferase activity]; heparan sulfate N-acetylglucosaminyltransferase activity ; heparan sulfate sulfotransferase activity ;
Cellular component	integral component of membrane ; Golgi apparatus ; membrane ; Golgi membrane ;
Biological process	cardiac septum development ; heparin biosynthetic process ; embryonic neurocranium morphogenesis ; coronary vasculature development ; respiratory gaseous exchange by respiratory system ; fibroblast growth factor receptor signaling pathway ; aorta development ; heart development ; glycosaminoglycan biosynthetic process ; animal organ morphogenesis ; embryonic viscerocranium morphogenesis ; polysaccharide biosynthetic process ; forebrain development ; metabolism ; protein sulfation ; inflammatory response ; midbrain development ; glycosaminoglycan metabolic process ; heparan sulfate proteoglycan biosynthetic process ; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ; positive regulation of MAPK cascade ; positive regulation of smoothened signaling pathway ; sulfur compound metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	3340
	15531
	ENSG00000070614
	ENSMUSG00000054008
	P52848
	Q3UHN9
	NM_001301063 ; NM_001543
NM_008306 ; NM_001348100 ; NM_001348101 ; NM_001348102 ; NM_001348103 ;
	NM_001348146
	NP_001287992 ; NP_001534
NP_032332 ; NP_001335029 ; NP_001335030 ; NP_001335031 ; NP_001335032 ;
	NP_001335075
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 05, 2022

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.^[5]^[6]^[7]

Related Research Articles

Glycosaminoglycans (GAGs) or mucopolysaccharides are long, linear polysaccharides consisting of repeating disaccharide units. The repeating two-sugar unit consists of a uronic sugar and an amino sugar, except in the case of the sulfated glycosaminoglycan keratan, where, in place of the uronic sugar there is a galactose unit. GAGs are found in vertebrates, invertebrates and bacteria. Because GAGs are highly polar molecules and attract water; the body uses them as lubricants or shock absorbers.

Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. It is in this form that HS binds to a variety of protein ligands, including Wnt, and regulates a wide range of biological activities, including developmental processes, angiogenesis, blood coagulation, abolishing detachment activity by GrB, and tumour metastasis. HS has also been shown to serve as cellular receptor for a number of viruses, including the respiratory syncytial virus. One study suggests that cellular heparan sulfate has a role in SARS-CoV-2 Infection, particularly when the virus attaches with ACE2.

In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 1 is an enzyme that catalyzes the chemical reaction

In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 2 is an enzyme that catalyzes the chemical reaction

In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 3 is an enzyme that catalyzes the chemical reaction

In enzymology, a [heparan sulfate]-glucosamine N-sulfotransferase is an enzyme that catalyzes the chemical reaction

Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides.

Syndecan-3 is a protein that in humans is encoded by the SDC3 gene.

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.

Sulfotransferase family cytosolic 1B member 1 is an enzyme that in humans is encoded by the SULT1B1 gene.

Exostosin-like 1 is a protein that in humans is encoded by the EXTL1 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 is an enzyme that in humans is encoded by the NDST2 gene.

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene. Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.

D-glucuronyl C5-epimerase is an enzyme that in humans is encoded by the GLCE gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene. It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate]_(n) = adenosine 3',5'-bisphosphate + 2 H⁺ + N-sulfo-α-D-glucosaminyl-[heparan sulfate]_(n)

Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.

Carbohydrate sulfotransferases are sulfotransferase enzymes that transfer sulfate to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular communication. Carbohydrates are suitable for such a wide variety of functions due to the diversity in structure generated from monosaccharide composition, glycosidic linkage positions, chain branching, and covalent modification. Possible covalent modifications include acetylation, methylation, phosphorylation, and sulfation. Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters. These sulfate esters are only located extracellularly, whether through excretion into the extracellular matrix (ECM) or by presentation on the cell surface. As extracellular compounds, sulfated carbohydrates are mediators of intercellular communication, cellular adhesion, and ECM maintenance.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000070614 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054008 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ (Aug 1995). "Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1". Genomics. 26 (2): 239–44. doi:10.1016/0888-7543(95)80206-2. PMID 7601448.
↑ Humphries DE, Sullivan BM, Aleixo MD, Stow JL (Aug 1997). "Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network". Biochem J. 325. ( Pt 2) (2): 351–7. doi:10.1042/bj3250351. PMC 1218567 . PMID 9230113.
↑ "Entrez Gene: NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1".

Sueyoshi T, Kakuta Y, Pedersen LC, et al. (1998). "A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase". FEBS Lett. 433 (3): 211–4. doi: 10.1016/S0014-5793(98)00913-2 . PMID 9744796. S2CID 9055616.
Aikawa J, Esko JD (1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J. Biol. Chem. 274 (5): 2690–5. doi: 10.1074/jbc.274.5.2690 . PMID 9915799.
Kakuta Y, Sueyoshi T, Negishi M, Pedersen LC (1999). "Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1". J. Biol. Chem. 274 (16): 10673–6. doi: 10.1074/jbc.274.16.10673 . PMID 10196134.
Pikas DS, Eriksson I, Kjellén L (2000). "Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns". Biochemistry. 39 (15): 4552–8. doi:10.1021/bi992524l. PMID 10758005.
Mura CV, Becker MI, Orellana A, Wolff D (2002). "Immunopurification of Golgi vesicles by magnetic sorting". J. Immunol. Methods. 260 (1–2): 263–71. doi:10.1016/S0022-1759(01)00546-4. PMID 11792394.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Bengtsson J, Eriksson I, Kjellén L (2003). "Distinct effects on heparan sulfate structure by different active site mutations in NDST-1". Biochemistry. 42 (7): 2110–5. doi:10.1021/bi026928g. PMID 12590599.
van den Born J, Pikas DS, Pisa BJ, et al. (2003). "Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2". Glycobiology. 13 (1): 1–10. doi: 10.1093/glycob/cwg011 . PMID 12634318.
Nakayama K, Natori Y, Sato T, et al. (2004). "Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis". J. Lab. Clin. Med. 143 (2): 106–14. doi:10.1016/j.lab.2003.10.012. PMID 14966466.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000070614 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054008 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7601448-5] Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ (Aug 1995). "Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1". Genomics. 26 (2): 239–44. doi:10.1016/0888-7543(95)80206-2. PMID 7601448.

[pmid9230113-6] Humphries DE, Sullivan BM, Aleixo MD, Stow JL (Aug 1997). "Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network". Biochem J. 325. ( Pt 2) (2): 351–7. doi:10.1042/bj3250351. PMC 1218567 . PMID 9230113.

[entrez-7] "Entrez Gene: NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1".

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NDST1

Related Research Articles

References

Further reading