NUDT3

NUDT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FVV, 2Q9P
Identifiers
Aliases	NUDT3 , DIPP, DIPP-1, DIPP1, nudix hydrolase 3
External IDs	OMIM: 609228 MGI: 1928484 HomoloGene: 31400 GeneCards: NUDT3
Gene location (Human)
Chr.	Chromosome 6 (human)
End	34,392,669 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	27,842,469 bp
RNA expression pattern
	Top expressed in
	inferior olivary nucleus; ; postcentral gyrus; ; Brodmann area 46; ; Brodmann area 10; ; middle frontal gyrus; ; Region I of hippocampus proper; ; external globus pallidus; ; entorhinal cortex; ; internal globus pallidus; ; frontal pole;
	Top expressed in
	entorhinal cortex; ; superior frontal gyrus; ; cingulate gyrus; ; primary motor cortex; ; prefrontal cortex; ; hippocampus proper; ; cerebellar cortex; ; superior colliculus; ; ganglionic eminence; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity ; inositol diphosphate tetrakisphosphate diphosphatase activity ; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity ; hydrolase activity ; diphosphoinositol-polyphosphate diphosphatase activity ; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity ; metal ion binding ; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity ; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity ; magnesium ion binding ; inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity ; inositol diphosphate pentakisphosphate diphosphatase activity ; inositol bisdiphosphate tetrakisphosphate diphosphatase activity ; endopolyphosphatase activity ; bis(5'-adenosyl)-hexaphosphatase activity ; bis(5'-adenosyl)-pentaphosphatase activity ; m7G(5')pppN diphosphatase activity ;
Cellular component	nucleus ; cytoplasm ; cytosol ;
Biological process	cell-cell signaling ; diadenosine polyphosphate catabolic process ; inositol phosphate metabolic process ; diphosphoinositol polyphosphate catabolic process ; diadenosine pentaphosphate catabolic process ; diadenosine hexaphosphate catabolic process ; adenosine 5'-(hexahydrogen pentaphosphate) catabolic process ; diphosphoinositol polyphosphate metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	11165
	56409
	ENSG00000272325
	ENSMUSG00000024213
	O95989
	Q9JI46
	NM_006703
	NM_001291046 ; NM_019837
	NP_006694
	NP_001277975 ; NP_062811
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 12, 2023

Diphosphoinositol polyphosphate phosphohydrolase 1 is an enzyme that in humans is encoded by the NUDT3 gene.^[5]^[6]

NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998).[supplied by OMIM]^[6]

Related Research Articles

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Diphosphoinositol polyphosphate phosphohydrolase 3-beta is an enzyme that in humans is encoded by the NUDT11 gene.

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NUDIX hydrolases are a superfamily of hydrolytic enzymes capable of cleaving nucleoside diphosphates linked to x, hence their name. The reaction yields nucleoside monophosphate (NMP) plus X-P. Substrates hydrolysed by nudix enzymes comprise a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity. Enzymes of the NUDIX superfamily are found in all types of organisms, including eukaryotes, bacteria and archaea.

Ghk.

Diadenosine hexaphosphate hydrolase (AMP-forming) (EC 3.6.1.60, hAps1, NUDT11 (gene), hAps2, NUDT10 (gene)) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (AMP-forming). This enzyme catalyses the following chemical reaction

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000272325 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024213 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (Jan 1999). "A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase". EMBO J. 17 (22): 6599–607. doi:10.1093/emboj/17.22.6599. PMC 1171006 . PMID 9822604.
1 2 "Entrez Gene: NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3".

Safrany ST, Ingram SW, Cartwright JL, et al. (1999). "The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein". J. Biol. Chem. 274 (31): 21735–40. doi: 10.1074/jbc.274.31.21735 . PMID 10419486.
Yang X, Safrany ST, Shears SB (2000). "Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates". J. Biol. Chem. 274 (50): 35434–40. doi: 10.1074/jbc.274.50.35434 . PMID 10585413.
Fisher DI, Safrany ST, Strike P, et al. (2003). "Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate". J. Biol. Chem. 277 (49): 47313–7. doi: 10.1074/jbc.M209795200 . PMID 12370170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000272325 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024213 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9822604-5] Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (Jan 1999). "A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase". EMBO J. 17 (22): 6599–607. doi:10.1093/emboj/17.22.6599. PMC 1171006 . PMID 9822604.

[entrez-6] 1 2 "Entrez Gene: NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3".

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NUDT3

Related Research Articles

References

Further reading