National Perinatal Epidemiology Unit

Last updated

The National Perinatal Epidemiology Unit (NPEU) is a multi-disciplinary research unit within the Nuffield Department of Population Health at Oxford University. It is located in the Richard Doll Building on the Old Road Campus, in Headington, east Oxford, England.

Contents

The unit's work involves randomized controlled trials, national surveillance programs and surveys and other research on maternal and infant health and care in the perinatal period (before, during and after birth). [1] The early work of the NPEU in developing a register of perinatal trials and methods for synthesizing their results lay the foundations for the Cochrane Collaboration. [2] [3]

Activities

The mission of the NPEU is "...to produce methodologically rigorous research evidence to improve the care provided to women and their families during pregnancy, childbirth, the newborn period and early childhood as well as promoting the effective use of resources by perinatal health services.” [4] Since its inception, a key area of its activities has been undertaking and supporting randomized controlled trials of the effects of perinatal care, now through the NPEU Clinical Trials Unit. [4] [5]

The NPEU runs the UK Obstetric Surveillance System (UKOSS), which is a national system studying rare disorders of pregnancy. [6] In 2011, the Policy Research Unit in Maternal Health and Care (PRUMC) was established at the NPEU. [4]

History

The NPEU's Classified Bibliography of Controlled Trials in Perinatal Medicine 1940-1984 Classified-bibliography-of-controlled-trials.JPG
The NPEU's Classified Bibliography of Controlled Trials in Perinatal Medicine 1940–1984

The NPEU was established in 1978 by the Department of Health at Oxford University, following a joint request for a national research institute by the Royal College of Obstetricians and Gynaecologists and the British Paediatric Association. [7] The Department gave the unit the task of providing "information which can promote effective use of resources in the perinatal health services." [7] From the beginning, the first NPEU Director, Iain Chalmers, was guided by the principles [7] for evaluating effectiveness of health care described by Archie Cochrane in his book, Effectiveness and Efficiency: Random Reflections on Health Services. [8]

From its early days, the NPEU was a leader in both randomized controlled trials to assess the effects of perinatal care, the retrieval of information, and the development and use of systematic reviews and meta-analyses to synthesize research results. [5] [9] The unit developed extensive national and international collaborations [5] which were to form both the basis of its work and lay the foundations for the development of the Cochrane Collaboration. [2] [3] [10] [11]

Beginning with a card file of references to perinatal trials and both manual and electronic searching for further trials, the NPEU developed first a book, the Classified Bibliography of Controlled Trials in Perinatal Medicine 1940–1984, [12] and then the Oxford Database of Perinatal Trials (ODPT). [2] [3] This process of developing a register of trials led to others establishing a register of trials in fertility [5] as well as the basis for the development of the Cochrane Controlled Trials Register (CCTR) when the NPEU's Director left to establish the UK Cochrane Centre in 1992, from where the Cochrane Collaboration evolved in 1993. [2] [13] By 1989, the synthesis of the results of perinatal research led to the publication of major books. By 1990, ODPT included electronic syntheses called overviews, which were the precursor for the Cochrane Collaboration's Cochrane Database of Systematic Reviews. [2]

In 2013, the NPEU was awarded a silver department Athena SWAN award for its commitment to advancing women's careers in science and medicine. [14]

Directors

Related Research Articles

<span class="mw-page-title-main">Acupressure</span> Alternative medicine technique similar to acupuncture

Acupressure is an alternative medicine technique often used in conjunction with acupuncture or reflexology. It is based on the concept of life energy, which flows through "meridians" in the body. In treatment, physical pressure is applied to acupuncture points, or ashi trigger points, with the aim of clearing blockages in these meridians. Pressure may be applied by hand, by elbow, or with various devices.

<span class="mw-page-title-main">Postpartum depression</span> Mood disorder experienced after childbirth

Postpartum depression (PPD), also called postnatal depression, is a type of mood disorder experienced after childbirth, which can affect both sexes. Symptoms may include extreme sadness, low energy, anxiety, crying episodes, irritability, and changes in sleeping or eating patterns. PPD can also negatively affect the newborn child.

<span class="mw-page-title-main">Doula</span> Non-medical companion who supports a person through significant health-related experiences

A doula is a trained professional who provides expert guidance for the service of others and who supports another person through a significant health-related experience, such as childbirth, miscarriage, induced abortion or stillbirth, as well as non-reproductive experiences such as dying. A doula might also provide support to the client's partner, family, and friends.

Archibald Leman Cochrane was a Scottish physician noted for his book, Effectiveness and Efficiency: Random Reflections on Health Services, which advocated the use of randomized controlled trials (RCTs) to improve clinical trials and medical interventions. His advocacy of RCTs eventually led to the creation of the Cochrane Library database of systematic reviews, the UK Cochrane Centre in Oxford and Cochrane, an international organization of review groups that are based at research institutions worldwide. He is known as one of the fathers of modern clinical epidemiology and is considered to be the originator of the idea of evidence-based medicine. The Archie Cochrane Archive is held at the Archie Cochrane Library at University Hospital Llandough, Penarth.

<span class="mw-page-title-main">Cochrane (organisation)</span> British nonprofit for reviews of medical research (formed 1993)

Cochrane is a British international charitable organisation formed to synthesize medical research findings to facilitate evidence-based choices about health interventions involving health professionals, patients and policy makers. It includes 53 review groups that are based at research institutions worldwide. Cochrane has approximately 30,000 volunteer experts from around the world.

<span class="mw-page-title-main">Systematic review</span> Comprehensive review of research literature using systematic methods

A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. A systematic review extracts and interprets data from published studies on the topic, then analyzes, describes, critically appraises and summarizes interpretations into a refined evidence-based conclusion. For example, a systematic review of randomized controlled trials is a way of summarizing and implementing evidence-based medicine.

<span class="mw-page-title-main">Iain Chalmers</span> British medical researcher

Sir Iain Geoffrey Chalmers is a British health services researcher, one of the founders of the Cochrane Collaboration, and coordinator of the James Lind Initiative, which includes the James Lind Library and James Lind Alliance.

The Jadad scale, sometimes known as Jadad scoring or the Oxford quality scoring system, is a procedure to assess the methodological quality of a clinical trial by objective criteria. It is named after Canadian-Colombian physician Alex Jadad who in 1996 described a system for allocating such trials a score of between zero and five (rigorous). It is the most widely used such assessment in the world, and as of 2022, its seminal paper has been cited in over 23,000 scientific works.

Early postnatal hospital discharge generally refers to the postpartum hospital discharge of the mother and newborn within 48 hours. The duration of what is considered "early discharge" varies between countries from 12 to 72 hours due to the differences in average duration of hospital stay. The World Health Organisation (WHO) recommends healthy mothers and newborns following an uncomplicated vaginal delivery at a health facility to stay and receive care at the facility for at least 24 hours after delivery. This recommendation is based on findings which suggest that the first 24 hours after giving birth poses the greatest risks for both the mother and newborn.

Alessandro Liberati was an Italian healthcare researcher and clinical epidemiologist, and founder of the Italian Cochrane Centre.

The United States Cochrane Center (USCC) was one of the 14 centers on the world that facilitated the work of the Cochrane Collaboration. The USCC was the reference center for all 50 US states and US territories, protectorates, and districts: the District of Columbia, American Samoa, Guam, the Northern Mariana Islands, Puerto Rico, and the US Virgin Islands. The USCC was also the reference Center for the following countries: Antigua and Barbuda, Bahamas, Barbados, Belize, Dominica, Grenada, Guam, Guyana, Jamaica, Japan, Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines, and Trinidad and Tobago. The USCC discontinued on February 7, 2018.

<span class="mw-page-title-main">Anne Anderson (researcher)</span> Scottish researcher

Anne Barbara Michie Anderson was a Scottish reproductive physiologist, researcher, lecturer, and author. Her major contributions were for her research in reproductive physiology. In the last decade of her life, she broadened this to encompass more about women's health generally, including doing clinical trials and working with people focusing in on what would become evidence-based medicine.

Kirsti Elina Hemminki is a Finnish academic who was trained in medicine and public health. She has wide research experience in health services and epidemiological research. Her research interests include use, determinants and consequences of medical technology, particularly in the field of preventive services. Many of her examples come from women's and children's health and drugs (medicines). Her interests include health services trials, and how ethical and governance rules apply to them. Her other research interests have included research policy and research regulation.

<span class="mw-page-title-main">Michael B. Bracken</span> Perinatal epidemiologist

Michael B. Bracken is an American perinatal epidemiologist. He is the Susan Dwight Bliss Professor of Epidemiology at the Yale School of Public Health, and Professor of Obstetrics, Gynecology and Reproductive Sciences, and Professor of Neurology at the Yale School of Medicine. He is co-director of the Yale Center for Perinatal, Pediatric and Environmental Epidemiology.

Kay Dickersin is an academic who trained first in cell biology and subsequently epidemiology. She went on to a career studying factors that influence research integrity, in particular publication bias and outcome reporting bias. She is retired Professor Emerita in the Department of Epidemiology at Johns Hopkins Bloomberg School of Public Health where she was Director of the Center for Clinical Trials and Evidence Synthesis there. She was also Director of the US Cochrane Center and the US Satellite of the Cochrane Eyes and Vision Group within the Cochrane Collaboration. Dickersin received multiple awards for her research.

<span class="mw-page-title-main">Further research is needed</span> Phrase commonly used in research papers

The phrases "further research is needed" (FRIN), "more research is needed" and other variants are commonly used in research papers. The cliché is so common that it has attracted research, regulation and cultural commentary.

Alejandro R. Jadad Bechara is a Canadian-Colombian physician whose work focuses on the creation of a pandemic of health through digital technologies and collaboration across traditional boundaries. He is also known as the researcher responsible for the development of the Jadad Scale, the first validated tool to assess the methodological quality of clinical trials.

<span class="mw-page-title-main">Murray Enkin</span> Canadian physician and writer (1924–2021)

Murray W. Enkin was a Canadian physician and writer. He was born in Toronto, Ontario, and studied medicine at the University of Toronto and later specialized as an obstetrician and gynaecologist at Long Island College Hospital in Brooklyn. He was a professor, philosopher, activist, public speaker and author, who contributed to the fields of maternal care and childbirth, and evidence-based medicine.

Jennifer J. Kurinczuk is a British physician who is a Professor of Perinatal Epidemiology and Director of the National Perinatal Epidemiology Unit at the University of Oxford. In 2019 she was named an Honorary Fellow of the Royal College of Obstetricians and Gynaecologists. During the COVID-19 pandemic, Kurinczuk investigated the neonatal complications of coronavirus disease.

Marian Knight is a British physician who is a Professor of Maternal and Child Population Health at the University of Oxford. She is an Honorary Consultant of Public Health for Public Health England. During the COVID-19 pandemic Knight studied the characteristics and outcomes of pregnant women who tested positive for COVID-19.

References

  1. "About us". National Perinatal Epidemiology Unit. Retrieved 14 December 2013.
  2. 1 2 3 4 5 Starr, M; Chalmers, I; Clarke, M; Oxman, AD (July 2009). "The origins, evolution, and future of The Cochrane Database of Systematic Reviews" (PDF). International Journal of Technology Assessment in Health Care. 25 (Suppl 1): 182–95. doi: 10.1017/s026646230909062x . PMID   19534840.
  3. 1 2 3 Chalmers, I. "Keeping systematic reviews up to date: a continuing challenge". Cochrane Collaboration. Retrieved 14 December 2013.
  4. 1 2 3 4 5 "NPEU Annual report 2011-12" (PDF). National Perinatal Epidemiology Unit. Archived from the original (PDF) on 23 November 2016. Retrieved 14 December 2013.
  5. 1 2 3 4 Lilford, RJ (September 1993). "National Perinatal Epidemiology Unit--a national asset". British Journal of Obstetrics and Gynaecology. 100 (9): 799. doi:10.1111/j.1471-0528.1993.tb14299.x. PMID   8217994. S2CID   19229268.
  6. "UK Obstetric Surveillance System (UKOSS)". National Perinatal Epidemiology Unit. Retrieved 14 December 2013.
  7. 1 2 3 Chalmers, I (1991). "The work of the National Perinatal Epidemiology Unit. One example of technology assessment in perinatal care". International Journal of Technology Assessment in Health Care. 7 (4): 430–59. doi: 10.1017/s0266462300007029 . PMID   1778692.
  8. Cochrane, A L (1972), Effectiveness and Efficiency: Random Reflections on Health Services (2nd ed.), London: Nuffield Provincial Hospitals Trust (published 1989), ISBN   978-0-7279-0282-5
  9. "Servicing perinatal research". The Lancet. 338 (8782–8783): 1564. 1991. doi:10.1016/0140-6736(91)92381-b. PMID   1683979. S2CID   6507258.
  10. Chalmers, I; Enkin, M; Keirse, MJNC, eds. (1989). Effective Care in Pregnancy and Childbirth . Oxford: Oxford University Press.
  11. Enkin, M; Keirse, MJNC; Chalmers, I (1989). A guide to effective care in pregnancy and childbirth . Oxford: Oxford University Press.
  12. National Perinatal Epidemiology Unit (1986). Classified Bibliography of Controlled Trials in Perinatal Medicine 1940–1984. Oxford: Oxford Medical Publications.
  13. 1 2 Watts, G (23 December 2006). "Iain Chalmers: maverick master of medical evidence". Lancet. 368 (9554): 2203. doi:10.1016/s0140-6736(06)69879-6. PMID   17189019. S2CID   46317599.
  14. "Medicine and engineering departments make headway on gender equality". Athena SWAN. 26 September 2013. Archived from the original on 15 December 2013. Retrieved 14 December 2013.
  15. "UK Cochrane Centre: Our history". UK Cochrane Centre. Archived from the original on 15 December 2013. Retrieved 14 December 2013.
  16. "Emeritus Professor Judith Lumley AM" (PDF). Public Health Association Australia. Retrieved 14 December 2013.
  17. "Biography: Peter Brocklehurst". National Perinatal Epidemiology Unit. Archived from the original on 24 July 2019. Retrieved 14 December 2013.
  18. NPEU News. "Dr Jenny Kurinczuk to become the new Director of the NPEU". National Perinatal Epidemiology Unit. Archived from the original on 24 September 2019. Retrieved 14 December 2013.