PHF2

PHF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KQI, 3PTR, 3PU3, 3PU8, 3PUA, 3PUS
Identifiers
Aliases	PHF2 , CENP-35, GRC5, JHDM1E, PHD finger protein 2, KDM7C
External IDs	OMIM: 604351 MGI: 1338034 HomoloGene: 3934 GeneCards: PHF2
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q22.31 Start 93,576,584 bp [1] End 93,679,587 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13 A5|13 24.96 cM Start 48,955,226 bp [2] End 49,024,595 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence cerebellar vermis internal globus pallidus anterior pituitary canal of the cervix tibial nerve left uterine tube right lung gastric mucosa gastrocnemius muscle Top expressed in ascending aorta aortic valve thymus lacrimal gland submandibular gland ganglionic eminence ureter triceps brachii muscle skeletal muscle tissue seminiferous tubule More reference expression data BioGPS n/a
Gene ontology Molecular function iron ion binding histone H3-methyl-lysine-9 demethylase activity transcription coactivator activity dioxygenase activity metal ion binding methylated histone binding protein binding oxidoreductase activity histone demethylase activity zinc ion binding Cellular component nucleoplasm chromosome nucleolus chromosome, centromeric region kinetochore nucleus Biological process regulation of transcription, DNA-templated histone H3-K9 demethylation protein demethylation transcription, DNA-templated negative regulation of ribosomal DNA heterochromatin assembly liver development chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5253 18676 Ensembl ENSG00000197724 ENSMUSG00000038025 UniProt O75151 Q9WTU0 RefSeq (mRNA) NM_005392 NM_024517 NM_011078 RefSeq (protein) NP_005383 NP_035208 Location (UCSC) Chr 9: 93.58 – 93.68 Mb Chr 13: 48.96 – 49.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PHD finger protein 2 is a protein that in humans is encoded by the PHF2 gene. ^[5]

Function

This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys ₄-His-Cys₃ arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.

References

1. GRCh38: Ensembl release 89: ENSG00000197724 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038025 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PHD finger protein 2" . Retrieved 2016-04-09.

Further reading

• Sinha S, Singh RK, Alam N, Roy A, Roychoudhury S, Panda CK (2008). "Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma". Mol. Cancer. 7: 84. doi:10.1186/1476-4598-7-84. PMC   2633285 . PMID   18990233.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.