PLA2R1

PLA2R1
Identifiers
Aliases	PLA2R1 , CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R, phospholipase A2 receptor 1
External IDs	OMIM: 604939 MGI: 102468 HomoloGene: 32016 GeneCards: PLA2R1
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q24.2 Start 159,932,006 bp [1] End 160,062,615 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 C1.1 Start 60,247,887 bp [2] End 60,383,652 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland left lobe of thyroid gland Achilles tendon right lobe of thyroid gland right coronary artery popliteal artery minor salivary gland skin of abdomen ascending aorta left coronary artery Top expressed in molar olfactory epithelium retinal pigment epithelium pineal gland belly cord uterus intercostal muscle maxillary prominence submandibular gland skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipase binding carbohydrate binding transmembrane signaling receptor activity signaling receptor activity Cellular component integral component of membrane extracellular region cell surface receptor complex plasma membrane membrane integral component of plasma membrane Biological process cytokine production positive regulation of DNA damage response, signal transduction by p53 class mediator endocytosis positive regulation of arachidonic acid secretion receptor-mediated endocytosis oxidative stress-induced premature senescence reactive oxygen species metabolic process replicative senescence signal transduction negative regulation of phospholipase A2 activity negative regulation of arachidonic acid secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22925 18779 Ensembl ENSG00000153246 ENSMUSG00000054580 UniProt Q13018 Q62028 RefSeq (mRNA) NM_001007267 NM_001195641 NM_007366 NM_008867 RefSeq (protein) NP_001007268 NP_001182570 NP_031392 NP_032893 Location (UCSC) Chr 2: 159.93 – 160.06 Mb Chr 2: 60.25 – 60.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Secretory phospholipase A2 receptor is a protein that in humans is encoded by the PLA2R1 gene. ^{[5] [6] [7]}

Clinical significance

M-type phospholipase A2 receptor is the major antigen in idiopathic membranous nephropathy attributed to over 70% of cases. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000153246 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054580 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ancian P, Lambeau G, Mattéi MG, Lazdunski M (Apr 1995). "The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization". The Journal of Biological Chemistry. 270 (15): 8963–70. doi: 10.1074/jbc.270.15.8963 . PMID   7721806.
6. Higashino K, Ishizaki J, Kishino J, Ohara O, Arita H (Oct 1994). "Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals". European Journal of Biochemistry. 225 (1): 375–82. doi: 10.1111/j.1432-1033.1994.00375.x . PMID   7925459.
7. "Entrez Gene: PLA2R1 phospholipase A2 receptor 1, 180kDa".
8. Beck LH, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ (Jul 2009). "M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy". The New England Journal of Medicine. 361 (1): 11–21. doi:10.1056/NEJMoa0810457. PMC   2762083 . PMID   19571279.

Further reading

• Silliman CC, Moore EE, Zallen G, Gonzalez R, Johnson JL, Elzi DJ, Meng X, Hanasaki K, Ishizaki J, Arita H, Ao L, England KM, Banerjee A (Oct 2002). "Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion". American Journal of Physiology. Cell Physiology. 283 (4): C1102–13. doi:10.1152/ajpcell.00608.2001. PMID   12225974.
• Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Molecular Vision. 8: 196–204. PMID   12107411.
• Morioka Y, Saiga A, Yokota Y, Suzuki N, Ikeda M, Ono T, Nakano K, Fujii N, Ishizaki J, Arita H, Hanasaki K (Sep 2000). "Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor". Archives of Biochemistry and Biophysics. 381 (1): 31–42. doi:10.1006/abbi.2000.1977. PMID   11019817.
• Yokota Y, Higashino K, Nakano K, Arita H, Hanasaki K (Jul 2000). "Identification of group X secretory phospholipase A(2) as a natural ligand for mouse phospholipase A(2) receptor". FEBS Letters. 478 (1–2): 187–91. doi: 10.1016/S0014-5793(00)01848-2 . PMID   10922494. S2CID   28188560.
• Yokota Y, Ikeda M, Higashino K, Nakano K, Fujii N, Arita H, Hanasaki K (Jul 2000). "Enhanced tissue expression and elevated circulating level of phospholipase A(2) receptor during murine endotoxic shock". Archives of Biochemistry and Biophysics. 379 (1): 7–17. doi:10.1006/abbi.2000.1849. PMID   10864436.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.