Peter Klinken

Last updated

Professor
Peter Klinken
AC FAHMS FTSE
Professor Peter Klinken.jpg
Professor Peter Klinken in 2018
3rd Chief Scientist of Western Australia
Assumed office
10 June 2014

While writing his PhD thesis, Klinken taught at Scotch College, Perth (Western Australia) from 1981 to 1983. After being awarded his PhD, he received a fellowship from the Fogarty International Center at the US National Institutes of Health in Bethesda, Maryland (1984–1986). He then returned to Australia and worked as a post-doctoral fellow at the Walter and Eliza Hall Institute of Medical Research in Melbourne 1987–1988. In 1989, he returned to an academic position at UWA, where he received two "Excellence in Teaching" Awards. In 1994 he was appointed UWA Professor of Clinical Biochemistry based at the Royal Perth Hospital, and in 2000 he became director of research at the Hospital. [4]

Klinken's research interests include the regulation of red blood cell formation, and the ability of leukaemic cells to develop different features and functions. He has a long-standing interest in identifying genes, which when altered can cause leukaemia and other cancers. During his career on the genetic causes of cancer, his laboratory team identified two genes (Mlf1 and Hls5) implicated in the development of leukaemias and cancers. His team participated in the Japanese-led FANTOM5 international consortium that investigated cellular trancriptomics. [5]

Achievements

Klinken played a key role in establishing the Western Australian Institute for Medical Research (WAIMR) [6] [7] in 1998, which later became known as the Harry Perkins Institute of Medical Research. [8] During his tenure as Executive Director from 2002 to 2014, the Institute grew from 63 to over 250 researchers and staff, and established a number of spin-off companies including Linear Clinical Research, an early phase-1 clinical trials facility. [9] Under his stewardship, the Institute attracted world-class researchers to Western Australia and made numerous acclaimed medical discoveries. [10] [11] He also spearheaded the $200m development of state-of-the-art medical research facilities for the Harry Perkins Institute at the QEII Medical Centre [12] [13] and the Fiona Stanley Hospital.

In June 2014, the Premier of Western Australia appointed Klinken as the third Chief Scientist of the state. [14] He currently reports directly to the Minister for Science, Dave Kelly, and provides independent, external advice on topics that are important to the future of science in the state. His advice includes broadening the state's economy through science and innovation, promoting Western Australia as a science leader nationally and internationally, and acting as an ambassador to raise the awareness of science in the community. He works closely with Science and Innovation in Western Australia to enhance collaboration, attract funding, build leading-edge scientific capability and promote science initiatives across Government, industry and academia. He was heavily involved with the Office of Science in the development of the state's "Science Statement", which identified five key sectors for scientific focus. He also played an important role in the development of the state’s Science and Innovation Framework, released in 2018. In June 2017, Klinken has been reappointed as Chief Scientist until June 2019.[ citation needed ]

Honours and recognitions

Professional responsibilities and engagements

Klinken has been a member of the Board of the Cancer Research Trust since 2009, and is on the Medical Research Advisory Committee of the Australian Cancer Research Foundation, as well as the Scientific Advisory Committee of the Children's Cancer Institute of Australia and the Lions Eye Institute. From 1992 to 2005 he provided support to the National Health and Medical Research Council (NHMRC) of Australia in a variety of roles, and served on the Council of Scotch College, Perth (2003–2008) as well as the Board of the Diabetes Research Foundation (2004–2008).[ citation needed ]

Klinken was Regional Editor of the International Journal of Biochemistry & Cell Biology (1994–2004) and was a member of the Editorial Board of Experimental Haematology (2000–2004). He was invited to be an inaugural member of the International Molecular Biology Network, and has participated in numerous institutional reviews.[ citation needed ]

Research publications

  1. Effect of inhibitors of Ornithine decarboxylase on retrovirus induced transformation of murine erythroid precursors in vitro. Cancer Res 46:6246–6429 (1986)
  2. Evolution of B cell lineage lymphomas in mice with a retrovirus-induced immunodeficiency syndrome MAIDS. J Immunol 140:1123–1131 (1987)
  3. Hemopoietic lineage conversion: v-raf oncogene converts Eμ-myc transgenic B cells into macrophages. Cell 53:857–867 (1988)
  4. In vitro derived leukaemic erythroid cell lines induced by a raf/myc retrovirus differentiate in response to erythropoietin. Proc Natl Acad Sci USA 85:8506–8510 (1988)
  5. v-cbl, a new oncogene from a dual-recombinant murine retrovirus that induced early B-lineage lymphomas. Proc Natl Acad Sci USA 86:1168–1172 (1989)
  6. Transformation of murine bone marrow cells with a raf/myc retrovirus yields clonally related mature B cells and macrophages. Mol Cell Biol 10:3562–3568 (1990)
  7. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphoma genesis in Eμ-myc transgenic mice. Cell 65:1–10 (1991)
  8. Erythropoietin-induced stimulation of differentiation and proliferation in J2E cells is not mimicked by chemical induction. Blood 80:412–419 (1992)
  9. A rapid fatal erythroleukemia caused by J2E cells can be treated ex vivo with erythropoietin. Leukemia 9:900–907 (1995)
  10. Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells. EMBO Journal 16:1610–1619 (1997)
  11. HLS7, a hemopoietic lineage switch gene homologous to the leukaemia-inducing gene MLF1. EMBO Journal 18:5559–5566 (1999)
  12. Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of Lyn. Cancer Res 61:2453–2458 (2001)
  13. HLS5, a novel RBCC family member isolated from a hemopoietic lineage switch is a candidate tumour suppressor. J Biol Chem 279:8181–8189 (2004)
  14. Myeloid Leukemia Factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule. J Biol Chem 281:38791-38800 (2006)
  15. Erythroid defects in TRa-/- mice. Blood 111: 3245–3248 (2008)
  16. Hls5 regulates erythroid differentiation by modulating Gata-1 activity. Blood 111: 1946–1950 (2008)
  17. Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Blood 113: 3845–3856 (2009)
  18. Gain-of-function Lyn induces anaemia: appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signalling. Blood 122: 262–271 (2013)
  19. A promoter level expression atlas. Nature 507:462–470 (2014)
  20. Complementing tissue characterisation by integrating transcriptome profiling from the Human Protein Atlas and from the FANTOM5 consortium'. NUCLEIC ACIDS RESEARCH, 43, pp. 6787–6798 (2015)
  21. Transcriptional enhancers lead waves of co-ordinated transcription in transitioning mammalian cells. Science 347:1010–1014 (2015)

Related Research Articles

<span class="mw-page-title-main">Erythropoietin</span> Protein that stimulates red blood cell production

Erythropoietin, also known as erythropoetin, haematopoietin, or haemopoietin, is a glycoprotein cytokine secreted mainly by the kidneys in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bone marrow. Low levels of EPO are constantly secreted in sufficient quantities to compensate for normal red blood cell turnover. Common causes of cellular hypoxia resulting in elevated levels of EPO include any anemia, and hypoxemia due to chronic lung disease.

<span class="mw-page-title-main">University of Western Australia</span> University in Perth, Western Australia

The University of Western Australia (UWA) is a public research university in the Australian state of Western Australia. The university's main campus is in Perth, the state capital, with a secondary campus in Albany and various other facilities elsewhere. UWA was established in 1911 by an act of the Parliament of Western Australia and began teaching students two years later. It is the sixth-oldest university in Australia and was Western Australia's only university until the establishment of Murdoch University in 1973. Because of its age and reputation, UWA is classed one of the "sandstone universities", an informal designation given to the oldest university in each state. The university also belongs to several more formal groupings, including the Group of Eight and the Matariki Network of Universities.

The Telethon Kids Institute is an Australian medical research institute focused on the prevention of paediatric disease and the development of improved treatments to improve the health and wellbeing of children. Telethon Kids has developed a particular focus on Aboriginal health and has more than 500 staff, post-graduate students and visiting scholars. Telethon Kids is located in the Perth suburb of Nedlands, in the Perth Children's Hospital building. Telethon Kids is an independent not-for-profit, non-government organisation with close affiliations with the University of Western Australia and the Perth Children's Hospital. It is named after the Channel Seven Perth Telethon.

<span class="mw-page-title-main">Sir Charles Gairdner Hospital</span> Hospital in Perth, Western Australia

Sir Charles Gairdner Hospital (SCGH) is a teaching hospital in Nedlands, Western Australia.

<span class="mw-page-title-main">Erythropoietin receptor</span> Protein-coding gene in the species Homo sapiens

The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a single carbohydrate chain resulting in an approximately 56-57 kDa protein found on the surface of EPO responding cells. It is a member of the cytokine receptor family. EpoR pre-exists as dimers. These dimers were originally thought to be formed by extracellular domain interactions, however, it is now assumed that it is formed by interactions of the transmembrane domain and that the original structure of the extracellular interaction site was due to crystallisation conditions and does not depict the native conformation. Binding of a 30 kDa ligand erythropoietin (Epo), changes the receptor's conformational change, resulting in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor. At present, the most well-established function of EpoR is to promote proliferation and rescue of erythroid progenitors from apoptosis.

Ian Jeffrey Constable is an Australian ophthalmologist and the founder and director of the Lions Eye Institute in Perth, Western Australia. He was the Foundation Lions Professor of Ophthalmology at the University of Western Australia, and the Foundation Director of UWA's Centre for Ophthalmology and Visual Science. He is now Patron of the Lions Eye Institute.

<span class="mw-page-title-main">Richard Pestell</span> Australian oncologist and endocrinologist

Richard G. Pestell is an Australian American oncologist and endocrinologist who is Distinguished Professor, Translational Medical Research, and the President of the Pennsylvania Cancer and Regenerative Medicine Research Center at the Baruch S. Blumberg Institute. He was previously Executive Vice President of Thomas Jefferson University and Director of the Sidney Kimmel Cancer Center of Thomas Jefferson University. Pestell was appointed an Officer of the Order of Australia in the 2019 Queen's Birthday Honours for distinguished service to medicine and medical education.

Suzanne Cory is an Australian molecular biologist. She has worked on the genetics of the immune system and cancer and has lobbied her country to invest in science. She is married to fellow scientist Jerry Adams, also a WEHI scientist, whom she met while studying for her PhD at the University of Cambridge, England.

The Ian Constable Lecture is an annual lecture given in Perth, Western Australia.

<span class="mw-page-title-main">Robert Gallo</span> American biomedical researcher

Robert Charles Gallo is an American biomedical researcher. He is best known for his role in establishing the human immunodeficiency virus (HIV) as the infectious agent responsible for acquired immune deficiency syndrome (AIDS) and in the development of the HIV blood test, and he has been a major contributor to subsequent HIV research.

Allen Charles Edward Eaves is the founding Director of the Terry Fox Laboratory for Hematology/Oncology Research, which over a 25-year period (1981–2006) he grew into an internationally recognized centre for the study of leukemia and stem cell research. His own research on chronic myelogenous leukemia (CML) has led the way to a new understanding of the disease. As Head of Hematology at the British Columbia Cancer Agency and the University of British Columbia for 18 years (1985–2003) he engineered the building of one of the first and largest bone marrow transplant programs in Canada. In recognition of his research accomplishments and leadership in moving basic science discoveries in stem cell biology into the clinic, he was elected President of the International Society of Cellular Therapy (1995–1997), Treasurer of the Foundation for the Accreditation of Cellular Therapy (1995–2002) and President of the American Society of Blood and Marrow Transplantation (1999–2000). In 2003 he was awarded the prestigious R. M. Taylor Medal by the Canadian Cancer Society and the National Cancer Institute of Canada. In 2016 he was awarded the Order of British Columbia as well as named Ernst and Young's Entrepreneur Of The Year™ Pacific.

<span class="mw-page-title-main">Doug Hilton</span> Australian molecular biologist

Douglas James Hilton is an Australian molecular biologist. He is the Director of the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia and Head of the Department of Medical Biology at the University of Melbourne. His research has focused on cytokines, signal transduction pathways and the regulation of blood cell formation (hematopoiesis). Since 2014, Hilton has been the President of the Association of the Australian Medical Research Institutes (AAMRI).

Aleksandra Filipovska is a Professor, Deputy Director of the ARC Centre of Excellence in Synthetic Biology and NHMRC Senior Research Fellow at the University of Western Australia, heading a research group at the Telethon Kids Institute. Specializing in biochemistry and molecular biology, she has made contributions to the understanding of human mitochondrial genetics in health and disease.

Professor Lynda (Lyn) Dent Beazley is a neuroscientist and educator based in Perth, Western Australia. She is currently an Honorary Distinguished Fellow at the Institute of Advanced Studies at the University of Western Australia, and the Sir Walter Murdoch Distinguished Professor of Science at Murdoch University. Among other awards, she has been named an Officer of the Order of Australia for her contributions to medical science a Fellow of the Australian Academy of Technology and Engineering and Fellow of the Australian Academy of Science.

Christobel Mary Saunders is a British-Australian oncologist and breast cancer specialist, who holds the position of Winthrop Professor of Surgical Oncology at the University of Western Australia.

<span class="mw-page-title-main">Bryan Williams (professor)</span>

Bryan Raymond George Williams Hon. FRSNZ, FAA is a molecular biologist from New Zealand, with expertise in innate immunity and cancer biology. He is emeritus director and distinguished scientist at the Hudson Institute of Medical Research in Melbourne, Australia, and professor in the Department of Molecular and Translational Science at Monash University.

The Harry Perkins Institute of Medical Research is a medical research centre based in Perth, Western Australia. It has facilities at the Queen Elizabeth II Medical Centre in Nedlands and Fiona Stanley Hospital in Murdoch. The institute was established in 1998 as the Western Australian Institute for Medical Research (WAIMR), and was renamed in 2013 in honour of Harry Perkins, its founding chairman.

<span class="mw-page-title-main">University of Western Australia School of Medicine</span> Medical school in Western Australia

The University of Western Australia Medical School is the medical school of The University of Western Australia, located in Perth, Western Australia. Established in 1957, it is the oldest medical school in Western Australia, with over 6000 alumni. Well known for its research and clinical teaching, the medical school is ranked 8th in the world and 1st in Australia by the 2019 Academic Ranking of World Universities in clinical medicine. The medical school is affiliated with various teaching hospitals in Perth such as Royal Perth Hospital and Sir Charles Gairdner Hospital. The medical school is also heavily affiliated with the Queen Elizabeth II Medical Centre and its various research institutes. The school has prominent researchers and clinicians amongst its faculty and alumni, including Nobel Prize laureates Barry Marshall and Robin Warren ; recipients of the Australian of the Year award Fiona Stanley and Fiona Wood; and cancer researcher Richard Pestell. The school has produced 11 Rhodes Scholars.

The Chief Scientist of Western Australia is an independent adviser to the Government of Western Australia on science and innovation within Western Australia. The Chief Scientist also advises on science in the economy, the development of scientific industries, and promoting the state's scientific leadership internationally within the Asia-Pacific region.

Lynn Corcoran is an American–Australian immunologist who is Professor of Immunology at the Walter and Eliza Hall Institute. Her research considers cancer, parasitology and immunology, with a focus on B cells biology. She was inducted into the Victorian government's Honour Roll in 2013.

References

  1. ↑ Peter Klinken appointed new Chief Scientist of WA, 10 June 2014, www.news.uwa.edu.au
  2. ↑ Companion (AC) in the General Division of the Order of Australia Archived 23 September 2017 at the Wayback Machine , 2017 Queen's Birthday Honours, www.gg.gov.au
  3. ↑ Graduates earn Queen's Birthday Honours, University News, 13 June 2017, www.news.uwa.edu.au
  4. ↑ Past director of Harry Perkins Institute, Professor Peter Klinken
  5. ↑ 2014 Annual Report, www.perkins.org.au Archived 20 March 2017 at the Wayback Machine
  6. ↑ Western Australian Institute for Medical Research (WAIMR), Australian Cancer Research Foundation
  7. ↑ "Bio – Professor Peter Klinken". Australian Cancer Research Foundation. Archived from the original on 2 February 2017. Retrieved 26 January 2017.
  8. ↑ Home page, Harry Perkins Institute of Medical Research
  9. ↑ Linear--About us, Linear Clinical Research
  10. ↑ Brain Growth and Disease, www.perkins.org.au
  11. ↑ Molecular Endocrinology and Pharmacology, www.perkins.org.au
  12. ↑ QEII Medical Centre, www.qeiimc.health.wa.gov.au
  13. ↑ Surprise ‘Thank you’ for Professor Peter Klinken, Annual Report 2014, Harry Perkins Institute of Medical Research, p.24
  14. ↑ Chief Scientist of WA, www.dpc.wa.gov.au Archived 2 February 2017 at the Wayback Machine
  15. ↑ "Fellowship of the Australian Academy of Health & Medical Sciences - October 2015" (PDF). Australian Academy of Health & Medical Sciences. Retrieved 12 October 2018.

Chief Scientist references

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.