A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and to further recognize and destroy any of the microorganisms associated with that agent that it may encounter in the future.
Fort Detrick is a United States Army Futures Command installation located in Frederick, Maryland. Fort Detrick was the center of the U.S. biological weapons program from 1943 to 1969. Since the discontinuation of that program, it has hosted most elements of the United States biological defense program.
The All-Union Science Production Association Biopreparat was the Soviet agency created in April 1974, which spearheaded the largest and most sophisticated offensive biological warfare programme the world has ever seen. It was a vast, ostensibly civilian, network employing 30–40,000 personnel and incorporating five major military-focused research institutes, numerous design and instrument-making facilities, three pilot plants and five dual-use production plants. The network pursued major offensive R&D programmes which genetically engineered microbial strains to be resistant to an array of antibiotics. In addition, bacterial agents were created with the ability to produce various peptides, yielding strains with wholly new and unexpected pathogenic properties.
Parke-Davis is a subsidiary of the pharmaceutical company Pfizer. Although Parke, Davis & Co. is no longer an independent corporation, it was once America's oldest and largest drug maker, and played an important role in medical history. In 1970 Parke-Davis was acquired by Warner-Lambert, which in turn was acquired by Pfizer in 2000.
The National Renewable Energy Laboratory (NREL) in the US specializes in the research and development of renewable energy, energy efficiency, energy systems integration, and sustainable transportation. NREL is a federally funded research and development center sponsored by the Department of Energy and operated by the Alliance for Sustainable Energy, a joint venture between MRIGlobal and Battelle. Located in Golden, Colorado, NREL is home to the National Center for Photovoltaics, the National Bioenergy Center, and the National Wind Technology Center.
The United States Army Medical Research Institute of Infectious Diseases is the U.S Army's main institution and facility for defensive research into countermeasures against biological warfare. It is located on Fort Detrick, Maryland, near Washington, D.C. and is a subordinate lab of the U.S. Army Medical Research and Development Command (USAMRDC), headquartered on the same installation.
H5N1 clinical trials are clinical trials concerning H5N1 vaccines, which are intended to provide immunization to influenza A virus subtype H5N1. They are intended to discover pharmacological effects and identify any adverse reactions the vaccines may achieve in humans.
The Walter Reed Army Institute of Research (WRAIR) is the largest biomedical research facility administered by the U.S. Department of Defense (DoD). The institute is centered at the Forest Glen Annex, in the Forest Glen Park part of the unincorporated Silver Spring urban area in Maryland just north of Washington, DC, but it is a subordinate unit of the U.S. Army Medical Research and Development Command (USAMRDC), headquartered at nearby Fort Detrick, Maryland. At Forest Glen, the WRAIR has shared a laboratory and administrative facility — the Sen Daniel K. Inouye Building, also known as Building 503 — with the Naval Medical Research Center since 1999.
Lester Martínez López is an American government official and former Army general who serves as the Assistant Secretary of Defense for Health Affairs since 2023. While in the United States Army, Martínez López was the first Hispanic to head the Army Medical and Research Command at Fort Detrick, Maryland. His responsibilities included overseeing the Army Medical Research Institute of Infectious Disease, which develops antidotes and vaccines for diseases soldiers might face on the battlefield.
The U.S. Army Biological Warfare Laboratories (USBWL) were a suite of research laboratories and pilot plant centers operating at Camp Detrick, Maryland, United States beginning in 1943 under the control of the U.S. Army Chemical Corps Research and Development Command. The USBWL undertook research and development into biocontainment, decontamination, gaseous sterilization, and agent production and purification for the U.S. offensive biological warfare program. The laboratories and their projects were discontinued in 1969.
JN-International Medical Corporation (JNIMC) is a U.S.-based biopharmaceutical corporation which since 1998 has been focused on developing vaccines and diagnostics for infectious disease for developing countries. This private corporation was founded in 1998 by Dr. Jeeri R. Reddy with the help of Dr. Kelly F. Lechtenberg in a small rural town, Oakland, Nebraska. From there it grew and expanded until in the year 2000 the corporation moved to Omaha, Nebraska.
Indian Immunologicals Limited (IIL) is a subsidiary of National Dairy Development Board. It is based in Hyderabad, Telangana, India. IIL is registered in India as a Public Limited Company under the Companies Act, 1956, It was established in 1982 by the National Dairy Development Board.
Eurogentec is an international biotechnology supplier, based in Belgium, that specializes in genomics and proteomics kits and reagents as well as cGMP biologics. The company was founded in 1985 as a spin-off from the University of Liège. Eurogentec's contract manufacturing organization facilities are licensed by the Belgian Ministry of Health to produce clinical trial and commercial biopharmaceutical material and also licensed by the US FDA to manufacture a commercial recombinant protein product for the US market. Eurogentec operates two manufacturing facilities in Belgium that provide custom biologics and oligonucleotide-based components for diagnostic and therapeutic/prophylactic applications.
The Golden LEAF Biomanufacturing Training and Education Center (BTEC) is a multidisciplinary instructional center at North Carolina State University that provides education and training to develop skilled professionals for the biomanufacturing industry. Biomanufacturing refers to the use of living organisms or other biological material to produce commercially viable products. Examples include therapeutic proteins, monoclonal antibodies, and vaccines for medical use; amino acids and enzymes for food manufacturing; and biofuels and biochemicals for industrial applications. BTEC provides hands-on education and training in bioprocessing concepts and biomanufacturing methods that comply with cGMP (current Good Manufacturing Practice), a set regulations published by the United States Food and Drug Administration (FDA).
RTS,S/AS01 is a recombinant protein-based malaria vaccine. It is the only malaria vaccine approved and in wide use. As of April 2022, the vaccine has been given to 1 million children living in areas with moderate-to-high malaria transmission, with millions more doses to be provided as the vaccine's production expands. It requires at least three doses in infants by age 2, with a fourth dose extending the protection for another 1-2 years. The vaccine reduces hospital admissions from severe malaria by around 30%.
Naval Medical Research Unit Six (NAMRU-6) is a biomedical research laboratory of the US Navy located in Lima, Peru. It is the only US military command located in South America. Its mission is to identify infectious disease threats of military and public health importance and to develop and evaluate interventions and products to mitigate those threats.
Makerere University Walter Reed Project (MUWRP) was established in 2002 for the primary purpose of HIV vaccine development and building of vaccine testing capability in Uganda. It is one of the 5 international research sites established by the Department of Defense (DoD) United States HIV Research Program (MHRP), a program centered at the Walter Reed Army Institute of Research (WRAIR) in Silver Spring, Maryland. MUWRP's main facility is centrally located in Kampala, near the Makerere University College of Health Sciences where the MUWRP laboratory is located. The main facility includes the clinic, administrative and data offices.
Moderna, Inc. is a pharmaceutical and biotechnology company based in Cambridge, Massachusetts that focuses on RNA therapeutics, primarily mRNA vaccines. These vaccines use a copy of a molecule called messenger RNA (mRNA) to carry instructions for proteins to produce an immune response. The company's name is derived from the terms "modified", "RNA", and "modern".
Valneva SE is a French biotech company headquartered in Saint-Herblain, France, developing and commercializing vaccines for infectious diseases. It has manufacturing sites in Livingston, Scotland; Solna, Sweden, and Vienna, Austria, with other offices in France, Canada and the United States.
WuXi Biologics is a global Contract Research Development and Manufacturing Organization (CRDMO) that provides open-access, integrated technology platforms for biologics drug development.
