Polysorbate 20

Last updated
Polysorbate 20
Polysorbate 20.png
Names
IUPAC name
Polyoxyethylene (20) sorbitan monolaurate
Other names
  • Kolliphor PS 20
  • Montanox 20
  • Polysorbate 20
  • PEG(20)sorbitan monolaurate
  • Alkest TW 20
  • Tween 20
  • Kotilen-20
Identifiers
ChemSpider
  • none
ECHA InfoCard 100.105.528 OOjs UI icon edit-ltr-progressive.svg
E number E432 (thickeners, ...)
RTECS number
  • TR7400000
UNII
Properties
C58H114O26
Molar mass 1226 g/mol
AppearanceClear, yellow to yellow-green viscous liquid.
Density 1.1 g/mL (approximate)
Boiling point >100 °C (212 °F; 373 K)
Surface tension:
CMC
8.04×10−5 M at 21 °C [1]
HLB
16.7 [1]
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Irritant
NFPA 704 (fire diamond)
NFPA 704.svgHealth (blue): no hazard codeFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability (yellow): no hazard codeSpecial hazards (white): no code
1
Flash point 110 °C (230 °F; 383 K)
Safety data sheet (SDS) External MSDS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
X mark.svgN  verify  (what is  Yes check.svgYX mark.svgN ?)

Polysorbate 20 (common commercial brand names include Kolliphor PS 20, [2] Scattics, Alkest TW 20, Tween 20, and Kotilen-20) is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan monolaurate. Its stability and relative nontoxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications. As the name implies, the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species. [3]

Contents

Food applications

Polysorbate 20 is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.

The World Health Organization has suggested acceptable daily intake limits of 0–25 mg of polyoxyethylene sorbitan esters per kg body weight. [4]

Biotechnical applications

In biological techniques and sciences, polysorbate 20 has a broad range of applications. For example, it is used:

Pharmaceutical applications

Polysorbate 20 is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.

Industrial and domestic applications

Polysorbate 20 is used in many brands of baby wipes.

Polysorbate 20 is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.

Polysorbate 20 is also used as wetting agent in rubber balers in the elastomer industry.

Polysorbate 20 has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies. [5]

See also

Related Research Articles

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<span class="mw-page-title-main">Surfactant</span> Substance that lowers the surface tension between a liquid and another material

Surfactants are chemical compounds that decrease the surface tension or interfacial tension between two liquids, a liquid and a gas, or a liquid and a solid. The word "surfactant" is a blend of surface-active agent, coined c. 1950. As they consist of a water-repellent and a water-attracting part, they enable water and oil to mix; they can form foam and facilitate the detachment of dirt.

A lysis buffer is a buffer solution used for the purpose of breaking open cells for use in molecular biology experiments that analyze the labile macromolecules of the cells. Most lysis buffers contain buffering salts and ionic salts to regulate the pH and osmolarity of the lysate. Sometimes detergents are added to break up membrane structures. For lysis buffers targeted at protein extraction, protease inhibitors are often included, and in difficult cases may be almost required. Lysis buffers can be used on both animal and plant tissue cells.

<span class="mw-page-title-main">Lecithin</span> Generic term for amphiphilic substances of plant and animal origin

Lecithin is a generic term to designate any group of yellow-brownish fatty substances occurring in animal and plant tissues which are amphiphilic – they attract both water and fatty substances, and are used for smoothing food textures, emulsifying, homogenizing liquid mixtures, and repelling sticking materials.

In organic chemistry, ethoxylation is a chemical reaction in which ethylene oxide adds to a substrate. It is the most widely practiced alkoxylation, which involves the addition of epoxides to substrates.

<span class="mw-page-title-main">Laundry detergent</span> Type of detergent used for cleaning laundry

Laundry detergent is a type of detergent used for cleaning dirty laundry (clothes). Laundry detergent is manufactured in powder and liquid form.

<span class="mw-page-title-main">Triton X-100</span> Chemical compound

Triton X-100 is a nonionic surfactant that has a hydrophilic polyethylene oxide chain and an aromatic hydrocarbon lipophilic or hydrophobic group. The hydrocarbon group is a 4-(1,1,3,3-tetramethylbutyl)-phenyl group. Triton X-100 is closely related to IGEPAL CA-630, which might differ from it mainly in having slightly shorter ethylene oxide chains. As a result, Triton X-100 is slightly more hydrophilic than Igepal CA-630 thus these two detergents may not be considered functionally interchangeable for most applications.

<span class="mw-page-title-main">Polysorbate 80</span> Nonionic surfactant and emulsifier used in food and cosmetics

Polysorbate 80 is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics. This synthetic compound is a viscous, water-soluble yellow liquid.

Sorbitan monostearate is an ester of sorbitan and stearic acid and is sometimes referred to as a synthetic wax.

<span class="mw-page-title-main">NP-40</span> Chemical compound

NP-40 is a commercially available detergent with CAS Registry Number 9016-45-9. NP-40 is an ethoxylated nonylphenol for non-ionic surfactants and can act as emulsifier and demulsifier agent.

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Sorbitan tristearate is a nonionic surfactant. It is variously used as a dispersing agent, emulsifier, and stabilizer, in food and in aerosol sprays. As a food additive, it has the E number E492. Brand names for polysorbates include Alkest, Canarcel, and Span. The consistency of sorbitan tristearate is waxy; its color is light cream to tan.

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IGEPAL CA-630 is a nonionic, non-denaturing detergent. Its official IUPAC name is octylphenoxypolyethoxyethanol. IGEPAL is a registered trademark of Rhodia.

Paint has four major components: pigments, binders, solvents, and additives. Pigments serve to give paint its color, texture, toughness, as well as determining if a paint is opaque or not. Common white pigments include titanium dioxide and zinc oxide. Binders are the film forming component of a paint as it dries and affects the durability, gloss, and flexibility of the coating. Polyurethanes, polyesters, and acrylics are all examples of common binders. The solvent is the medium in which all other components of the paint are dissolved and evaporates away as the paint dries and cures. The solvent also modifies the curing rate and viscosity of the paint in its liquid state. There are two types of paint: solvent-borne and water-borne paints. Solvent-borne paints use organic solvents as the primary vehicle carrying the solid components in a paint formulation, whereas water-borne paints use water as the continuous medium. The additives that are incorporated into paints are a wide range of things which impart important effects on the properties of the paint and the final coating. Common paint additives are catalysts, thickeners, stabilizers, emulsifiers, texturizers, biocides to fight bacterial growth, etc.

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<span class="mw-page-title-main">Fabric treatment</span>

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References

  1. 1 2 Chunhee Kim; You-Lo Hsieh (2001). "Wetting and absorbency of nonionic surfactant solutions on cotton fabrics". Colloids and Surfaces A. 187: 385–397. doi:10.1016/S0927-7757(01)00653-7.
  2. "Polysorbates and Sorbitan Esters for Pharmaceutical Applications". BASF Pharma. Retrieved 2022-06-10.
  3. Ayorinde FO; Gelain SV; Johnson JH Jr; Wan LW. (2000). "Analysis of some commercial polysorbate formulations using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry". Rapid Communications in Mass Spectrometry. 14 (22): 2116–2124. Bibcode:2000RCMS...14.2116A. doi:10.1002/1097-0231(20001130)14:22<2116::AID-RCM142>3.0.CO;2-1. PMID   11114018.
  4. Joint FAO/WHO Expert Committee on Food Additives (1974). "Toxicological evaluation of some food additives including anticaking agents, antimicrobials, antioxidants, emulsifiers and thickening agents". WHO Food Additives Series No. 5. World Health Organization.
  5. Q. Maqbool, C. Singh, A. Paul and A. Srivastava J. Mat. Chem. C, 2015, 3, 1610