In chemistry, a glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous important roles in living organisms. Many plants store chemicals in the form of inactive glycosides. These can be activated by enzyme hydrolysis, which causes the sugar part to be broken off, making the chemical available for use. Many such plant glycosides are used as medications. Several species of Heliconius butterfly are capable of incorporating these plant compounds as a form of chemical defense against predators. In animals and humans, poisons are often bound to sugar molecules as part of their elimination from the body.
Saponins, also selectively referred to as triterpene glycosides, are bitter-tasting usually toxic plant-derived organic chemicals that have a foamy quality when agitated in water. They are widely distributed but found particularly in soapwort, a flowering plant, the soapbark tree and soybeans. They are used in soaps, medicines, fire extinguishers, speciously as dietary supplements, for synthesis of steroids, and in carbonated beverages. Saponins are both water and fat soluble, which gives them their useful soap properties. Some examples of these chemicals are glycyrrhizin and quillaia, a bark extract used in beverages.
Quillaia is the milled inner bark or small stems and branches of the soapbark. Other names include Murillo bark extract, Panama bark extract, Quillaia extract, Quillay bark extract, and Soapbark extract. Quillaia contains high concentrations of saponins that can be increased further by processing. Highly purified saponins from quillaia are used as adjuvants to enhance the effectiveness of vaccines. Other compounds in the crude extract include tannins and other polyphenols, and calcium oxalate.
QS-21 is a purified plant extract used as a vaccine adjuvant. It is derived from the soap bark tree, which is native to the countries of Chile, Peru, and Bolivia. The crude drug is imported from Peru and Chile.
Saponaria is a genus of flowering plants in the family Caryophyllaceae, native to Asia and Europe, and are commonly known as soapworts. They are herbaceous perennials and annuals, some with woody bases. The flowers are abundant, five-petalled and usually in shades of pink or white. The genus is closely related to the genus Silene, being distinguished from these by having only two styles in the flower. It is also related to Gypsophila, but its calyx is cylindrical rather than bell-shaped.
Jubaea is a genus of palms with one species, Jubaea chilensis, commonly known in English as the Chilean wine palm or Chile cocopalm, and palma chilena in Spanish. It is native to southwestern South America and is endemic to a small area of central Chile between 32°S and 35°S in southern Coquimbo, Valparaíso, Santiago, O'Higgins, and northern Maule regions.
Agenus Inc. is a Lexington, Massachusetts-based biotechnology company focused on immunotherapy including immuno-oncology, a field that uses the immune system to control or cure cancer. The company is developing checkpoint modulators (CPMs), patient-specific anti-cancer vaccines, and adjuvants desugned for use with various vaccines. CPM development is a particularly fast-moving field, since early products have produced unprecedented clinical benefits for patients.
In immunology, an adjuvant is a substance that increases or modulates the immune response to a vaccine. The word "adjuvant" comes from the Latin word adiuvare, meaning to help or aid. "An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific vaccine antigens."
Maytenus boaria (mayten) is an evergreen tree of the family Celastraceae, native from South America, up to 20 m (66 ft), 80 cm (31 in) diameter, straight trunk. It occurs naturally approximately from 30 to 50°S: Chile.
Cryptocarya alba, the peumo or Chilean acorn, is an evergreen tree that grows in Chile and Argentina from 33 to 40° southern latitude. It can live both in wet and as in dry conditions. Its distribution can reach up to 1500 meters (5000 ft) above sea level. It measures up to 20 meters (65 ft) height and one meter diameter, with cracked gray bark. An associate tree is the endangered Chilean Wine Palm, Jubaea chilensis, which species prehistorically had a much wider range.
Beilschmiedia berteroana is a threatened evergreen tree in the family Lauraceae endemic to Chile at 35 to 37°S.
The native flora of Chile is characterized by a higher degree of endemism and relatively fewer species compared to the flora of other countries of South America. A classification of this flora necessitates its division into at least three general zones: the desert provinces of the north, Central Chile, and the humid regions of the south.
Kageneckia oblonga is a species of plant in the family Rosaceae. It is endemic to Chile. K. oblonga is an evergreen tree. It grows from Coquimbo to Malleco. Example occurrences are found specifically found in central Chile within the La Campana National Park and Cerro La Campana forest areas. In these areas the endangered Chilean Wine Palm, Jubaea chilensis is an associated tree species.
Quillaja is a genus of flowering plants, the only extant genus in the family Quillajaceae with two or three known species. It was once thought to be in the rose family, Rosaceae, but recent research shows it belongs in its own family. The inner bark of the soap bark tree contains saponin, which is a natural soap. Members of this genus are trees that grow to about 25 metres (82 ft).
Immune stimulating complexes (ISCOMs) are spherical open cage-like structures (typically 40 nm in diameter) that are spontaneously formed when mixing together cholesterol, phospholipids and Quillaja saponins under a specific stoichiometry. The complex displays immune stimulating properties and is thus mainly used as a vaccine adjuvant in order to induce a stronger immune response and longer protection. A specific adjuvant based on ISCOM technology is Matrix-M.
Dasyphyllum excelsum is a species of flowering plant in the family Asteraceae. This species is endemic to Chile, occurring from Quillota to Cauquenes between 190 and 800 m above sea level, a specific location of occurrence being in central Chile within the Cerro La Campana forests in association with the endangered Chilean wine palm, Jubaea chilensis.
Retanilla trinervia is a species of actinorhizal plant within the family Rhamnaceae; this dicotyledon flora is a shrub or small tree. R. trinervia is notable for its ability to fix nitrogen. This species mainly occurs in the near coastal forests and arid shrubland of Chile. Example occurrences are found in the mountains of central Chile; for example, it occurs in the La Campana National Park in association with Acacia caven and Jubaea chilensis. as well as other proximate areas of central Chile.
Novavax, Inc. is an American biotechnology company based in Gaithersburg, Maryland, that develops vaccines to counter serious infectious diseases. Prior to 2020, company scientists developed experimental vaccines for influenza and respiratory syncytial virus (RSV), as well as Ebola and other emerging infectious diseases. During 2020, the company redirected its efforts to focus on development and approval of its NVX-CoV2373 vaccine for COVID-19.
Matrix-M is a vaccine adjuvant, a substance that is added to various vaccines to stimulate the immune response. It was patented in 2020 by Novavax and is composed of nanoparticles from saponins extracted from Quillaja saponaria (soapbark) trees, cholesterol, and phospholipids. It is an immune stimulating complex (ISCOM), which are nanospheres formed when saponin is mixed with two types of fats.
M72/AS01E is an experimental tuberculosis vaccine. If approved, it would be the first vaccine for tuberculosis in more than a century after the BCG vaccine.
