DNA repair protein RAD51 homolog 2 is a protein that in humans is encoded by the RAD51L1 gene. [5] [6] [7]
DNA repair protein RAD51 homolog 2 is a protein that in humans is encoded by the RAD51L1 gene. [5] [6] [7]
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. [7]
RAD51L1 has been shown to interact with RAD51C. [8] [9] [10]
RecQ helicase is a family of helicase enzymes initially found in Escherichia coli that has been shown to be important in genome maintenance. They function through catalyzing the reaction ATP + H2O → ADP + P and thus driving the unwinding of paired DNA and translocating in the 3' to 5' direction. These enzymes can also drive the reaction NTP + H2O → NDP + P to drive the unwinding of either DNA or RNA.
RAD51 is a eukaryotic gene. The enzyme encoded by this gene is a member of the RAD51 protein family which assists in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA, Archaeal RadA and yeast Rad51. The protein is highly conserved in most eukaryotes, from yeast to humans.
DNA repair protein XRCC4 also known as X-ray repair cross-complementing protein 4 or XRCC4 is a protein that in humans is encoded by the XRCC4 gene. In addition to humans, the XRCC4 protein is also expressed in many other metazoans, fungi and in plants. The X-ray repair cross-complementing protein 4 is one of several core proteins involved in the non-homologous end joining (NHEJ) pathway to repair DNA double strand breaks (DSBs).
Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system.
Cell cycle checkpoint protein RAD17 is a protein that in humans is encoded by the RAD17 gene.
DNA repair protein XRCC3 is a protein that in humans is encoded by the XRCC3 gene.
Bloom syndrome protein is a protein that in humans is encoded by the BLM gene and is not expressed in Bloom syndrome.
Cell cycle checkpoint protein RAD1 is a protein that in humans is encoded by the RAD1 gene.
Fanconi anemia group G protein is a protein that in humans is encoded by the FANCG gene.
RAD52 homolog , also known as RAD52, is a protein which in humans is encoded by the RAD52 gene.
RAD51 homolog C , also known as RAD51C, is a protein which in humans is encoded by the RAD51C gene.
DNA repair protein RAD51 homolog 4 is a protein that in humans is encoded by the RAD51L3 gene.
DNA repair protein XRCC2 is a protein that in humans is encoded by the XRCC2 gene.
DNA repair and recombination protein RAD54-like is a protein that in humans is encoded by the RAD54L gene.
Meiotic recombination protein DMC1/LIM15 homolog is a protein that in humans is encoded by the DMC1 gene.
E3 ubiquitin-protein ligase FANCL is an enzyme that in humans is encoded by the FANCL gene.
Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene.
DNA repair and recombination protein RAD54B is a protein that in humans is encoded by the RAD54B gene.
DNA replication licensing factor MCM8 is a protein that in humans is encoded by the MCM8 gene.
ZGRF1 is a protein in humans that is encoded by the ZGRF1 gene that has a weight of 236.6 kDa. The ZGRF1 gene product localizes to the cell nucleus and promotes DNA repair by stimulating homologous recombination. This gene shows relatively low expression in most human tissues, with increased expression in situations of chemical dependence. ZGRF1 is orthologous to nearly all kingdoms of Eukarya. Functional domains of this protein link it to a series of helicases, most notably the AAA_12 and AAA_11 domains.
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