RBM6

RBM6
Identifiers
Aliases	RBM6 , 3G2, DEF-3, DEF3, HLC-11, NY-LU-12, g16, RNA binding motif protein 6
External IDs	OMIM: 606886 MGI: 1338037 HomoloGene: 31336 GeneCards: RBM6
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 49,940,007 bp [1] End 50,100,045 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F1 Start 107,650,758 bp [2] End 107,750,436 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in canal of the cervix gastric mucosa right uterine tube cerebellar hemisphere anterior pituitary left lobe of thyroid gland right lobe of thyroid gland body of pancreas sural nerve left uterine tube Top expressed in spermatocyte ganglionic eminence morula secondary oocyte superior frontal gyrus spermatid cerebellar cortex thymus neural tube duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding nucleic acid binding RNA binding Cellular component nucleus Biological process RNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10180 19654 Ensembl ENSG00000004534 ENSMUSG00000032582 UniProt P78332 n/a RefSeq (mRNA) NM_001167582 NM_005777 NM_001349190 NM_001349191 NM_001349192 NM_001349193 NM_001349194 NM_011251 NM_029169 RefSeq (protein) NP_001161054 NP_005768 NP_001336119 NP_001336120 NP_001336121 NP_001336122 NP_001336123 n/a Location (UCSC) Chr 3: 49.94 – 50.1 Mb Chr 9: 107.65 – 107.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RNA-binding protein 6 is a protein that in humans is encoded by the RBM6 gene. ^{[5] [6]} RBM6 orthologs ^[7] have been identified in all mammals for which complete genome data are available.

RBM6 splicing factor interacts with the DNA repair protein RAD51, and is also recruited to DNA double-strand breaks where it promotes homologous recombinational repair. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000004534 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032582 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Timmer T, Terpstra P, van den Berg A, Veldhuis PM, Ter Elst A, Voutsinas G, Hulsbeek MM, Draaijers TG, Looman MW, Kok K, Naylor SL, Buys CH (Aug 1999). "A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3". Eur J Hum Genet. 7 (4): 478–86. doi: 10.1038/sj.ejhg.5200334 . PMID   10352938.
6. "Entrez Gene: RBM6 RNA binding motif protein 6".
7. "OrthoMaM phylogenetic marker: RBM6 coding sequence". Archived from the original on 2016-03-03. Retrieved 2009-12-09.
8. Awwad SW, Darawshe MM, Machour FE, Arman I, Ayoub N. Recruitment of RBM6 to DNA Double-Strand Breaks Fosters Homologous Recombination Repair. Mol Cell Biol. 2023;43(3):130-142. doi: 10.1080/10985549.2023.2187105. PMID: 36941773; PMCID: PMC10038030

Further reading

• Güre AO, Altorki NK, Stockert E, Scanlan MJ, Old LJ, Chen YT (1998). "Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3". Cancer Res. 58 (5): 1034–41. PMID   9500467.
• Drabkin HA, West JD, Hotfilder M, Heng YM, Erickson P, Calvo R, Dalmau J, Gemmill RM, Sablitzky F (1999). "DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC". Oncogene. 18 (16): 2589–97. doi:10.1038/sj.onc.1202601. PMID   10353602. S2CID   24925641.
• Timmer T, Terpstra P, van den Berg A, Veldhuis PM, Ter Elst A, Van Der Veen AY, Kok K, Naylor SL, Buys CH (1999). "An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3, a region frequently deleted in a variety of cancers". Genomics. 60 (2): 238–40. doi:10.1006/geno.1999.5878. PMID   10486216.
• Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID   11085536.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Gu TL, Mercher T, Tyner JW, Goss VL, Walters DK, Cornejo MG, Reeves C, Popova L, Lee K (2007). "A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia". Blood. 110 (1): 323–33. doi:10.1182/blood-2006-10-052282. PMC   1896120 . PMID   17360941.
• Wang K, Ubriaco G, Sutherland LC (2007). "RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours". BMC Genomics. 8: 348. doi: 10.1186/1471-2164-8-348 . PMC   2174484 . PMID   17908320.

External links

• RBM6 human gene location in the UCSC Genome Browser .
• RBM6 human gene details in the UCSC Genome Browser .