RGS16

RGS16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BT2, 2IK8
Identifiers
Aliases	RGS16 , A28-RGS14, A28-RGS14P, RGS-R, regulator of G-protein signaling 16, regulator of G protein signaling 16
External IDs	OMIM: 602514 MGI: 108407 HomoloGene: 2196 GeneCards: RGS16
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q25.3 Start 182,598,623 bp [1] End 182,604,389 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 G3|1 65.43 cM Start 153,616,095 bp [2] End 153,621,214 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava oocyte left lobe of thyroid gland right lobe of thyroid gland anterior pituitary saphenous vein gastric mucosa secondary oocyte gallbladder lymph node Top expressed in medial geniculate nucleus suprachiasmatic nucleus medial dorsal nucleus lateral geniculate nucleus internal carotid artery external carotid artery islet of Langerhans inferior colliculus entorhinal cortex Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity calmodulin binding GTPase activity Cellular component cytoplasm plasma membrane membrane intrinsic component of membrane Biological process negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway visual perception positive regulation of GTPase activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6004 19734 Ensembl ENSG00000143333 ENSMUSG00000026475 UniProt O15492 P97428 RefSeq (mRNA) NM_002928 NM_011267 RefSeq (protein) NP_002919 NP_035397 Location (UCSC) Chr 1: 182.6 – 182.6 Mb Chr 1: 153.62 – 153.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene. ^{[5] [6]}

Function

The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. ^[6]

Interactions

RGS16 has been shown to interact with GNAQ ^[7] and GNAI3. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000143333 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026475 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Snow BE, Antonio L, Suggs S, Siderovski DP (Jan 1998). "Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene". Gene. 206 (2): 247–53. doi:10.1016/S0378-1119(97)00593-3. PMID   9469939.
6. "Entrez Gene: RGS16 regulator of G-protein signalling 16".
7. Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (Dec 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID   14634662. S2CID   6798899.
8. Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". The Journal of Biological Chemistry. 272 (13): 8679–85. doi: 10.1074/jbc.272.13.8679 . PMID   9079700.
9. Beadling C, Druey KM, Richter G, Kehrl JH, Smith KA (Mar 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes". Journal of Immunology. 162 (5): 2677–82. doi: 10.4049/jimmunol.162.5.2677 . PMID   10072511.

Further reading

• Berman DM, Wilkie TM, Gilman AG (Aug 1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. 86 (3): 445–52. doi: 10.1016/S0092-8674(00)80117-8 . PMID   8756726. S2CID   12427406.
• De Vries L, Zheng B, Fischer T, Elenko E, Farquhar MG (2000). "The regulator of G protein signaling family". Annual Review of Pharmacology and Toxicology. 40: 235–71. doi:10.1146/annurev.pharmtox.40.1.235. PMID   10836135.
• Chen CK, Wieland T, Simon MI (Nov 1996). "RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling". Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 12885–9. Bibcode:1996PNAS...9312885C. doi: 10.1073/pnas.93.23.12885 . PMC   24015 . PMID   8917514.
• Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". The Journal of Biological Chemistry. 272 (13): 8679–85. doi: 10.1074/jbc.272.13.8679 . PMID   9079700.
• Buckbinder L, Velasco-Miguel S, Chen Y, Xu N, Talbott R, Gelbert L, Gao J, Seizinger BR, Gutkind JS, Kley N (Jul 1997). "The p53 tumor suppressor targets a novel regulator of G protein signaling". Proceedings of the National Academy of Sciences of the United States of America. 94 (15): 7868–72. Bibcode:1997PNAS...94.7868B. doi: 10.1073/pnas.94.15.7868 . PMC   21521 . PMID   9223279.
• Luo X, Popov S, Bera AK, Wilkie TM, Muallem S (Mar 2001). "RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations". Molecular Cell. 7 (3): 651–60. doi: 10.1016/S1097-2765(01)00211-8 . PMID   11463389.
• Natochin M, Lipkin VM, Artemyev NO (Jul 1997). "Interaction of human retinal RGS with G-protein alpha-subunits". FEBS Letters. 411 (2–3): 179–82. doi: 10.1016/S0014-5793(97)00687-X . PMID   9271201. S2CID   84269212.
• Beadling C, Druey KM, Richter G, Kehrl JH, Smith KA (Mar 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes". Journal of Immunology. 162 (5): 2677–82. doi: 10.4049/jimmunol.162.5.2677 . PMID   10072511.
• Druey KM, Ugur O, Caron JM, Chen CK, Backlund PS, Jones TL (Jun 1999). "Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling". The Journal of Biological Chemistry. 274 (26): 18836–42. doi: 10.1074/jbc.274.26.18836 . PMID   10373502.
• Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM (Apr 2011). "Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner". The Journal of Biological Chemistry. 286 (17): 15116–25. doi: 10.1074/jbc.M110.216234 . PMC   3083217 . PMID   21357625.
• Popov S, Yu K, Kozasa T, Wilkie TM (Jul 1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro". Proceedings of the National Academy of Sciences of the United States of America. 94 (14): 7216–20. Bibcode:1997PNAS...94.7216P. doi: 10.1073/pnas.94.14.7216 . PMC   23796 . PMID   9207071.
• Popov SG, Krishna UM, Falck JR, Wilkie TM (Jun 2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity". The Journal of Biological Chemistry. 275 (25): 18962–8. doi: 10.1074/jbc.M001128200 . PMID   10747990.
• Zheng B, Chen D, Farquhar MG (Apr 2000). "MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16". Proceedings of the National Academy of Sciences of the United States of America. 97 (8): 3999–4004. Bibcode:2000PNAS...97.3999Z. doi: 10.1073/pnas.97.8.3999 . PMC   18131 . PMID   10760272.
• Chatterjee TK, Fisher RA (Aug 2000). "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs". The Journal of Biological Chemistry. 275 (31): 24013–21. doi: 10.1074/jbc.M002082200 . PMID   10791963.
• Wieland T, Bahtijari N, Zhou XB, Kleuss C, Simon MI (Sep 2000). "Polarity exchange at the interface of regulators of G protein signaling with G protein alpha-subunits". The Journal of Biological Chemistry. 275 (37): 28500–6. doi: 10.1074/jbc.M004187200 . PMID   10878019.
• Chen C, Wang H, Fong CW, Lin SC (Aug 2001). "Multiple phosphorylation sites in RGS16 differentially modulate its GAP activity". FEBS Letters. 504 (1–2): 16–22. doi: 10.1016/S0014-5793(01)02757-0 . PMID   11522288.
• Derrien A, Druey KM (Dec 2001). "RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation". The Journal of Biological Chemistry. 276 (51): 48532–8. doi: 10.1074/jbc.M108862200 . PMID   11602604.
• Derrien A, Zheng B, Osterhout JL, Ma YC, Milligan G, Farquhar MG, Druey KM (May 2003). "Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability". The Journal of Biological Chemistry. 278 (18): 16107–16. doi: 10.1074/jbc.M210371200 . PMID   12588871.
• Osterhout JL, Waheed AA, Hiol A, Ward RJ, Davey PC, Nini L, Wang J, Milligan G, Jones TL, Druey KM (May 2003). "Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling". The Journal of Biological Chemistry. 278 (21): 19309–16. doi: 10.1074/jbc.M210124200 . PMID   12642592.
• Hiol A, Davey PC, Osterhout JL, Waheed AA, Fischer ER, Chen CK, Milligan G, Druey KM, Jones TL (May 2003). "Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue". The Journal of Biological Chemistry. 278 (21): 19301–8. doi: 10.1074/jbc.M210123200 . PMID   12642593.
• Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (Dec 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID   14634662. S2CID   6798899.
• Ross EM, Wilkie TM (2000). "GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". Annual Review of Biochemistry. 69: 795–827. doi:10.1146/annurev.biochem.69.1.795. PMID   10966476. S2CID   11637673.
• Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM (Feb 2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID   11829488. S2CID   16065132.
• Villasenor A, Wang ZV, Rivera LB, Ocal O, Asterholm IW, Scherer PE, Brekken RA, Cleaver O, Wilkie TM (2010). "Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes". Disease Models & Mechanisms. 3 (9–10): 567–80. doi:10.1242/dmm.003210. PMC   2931535 . PMID   20616094.
• Wilkie TM, Kinch L (Oct 2005). "New roles for Galpha and RGS proteins: communication continues despite pulling sisters apart". Current Biology. 15 (20): R843-54. Bibcode:2005CBio...15.R843W. doi: 10.1016/j.cub.2005.10.008 . PMID   16243026. S2CID   18174795.