RNF4

Last updated
RNF4
Protein RNF4 PDB 2EA6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RNF4 , SLX5, SNURF, RES4-26, ring finger protein 4
External IDs OMIM: 602850 MGI: 1201691 HomoloGene: 37711 GeneCards: RNF4
Orthologs
SpeciesHumanMouse
Entrez

6047

19822

Ensembl

ENSG00000063978

ENSMUSG00000029110

UniProt

P78317

Q9QZS2

RefSeq (mRNA)

NM_002938
NM_001185009
NM_001185010

NM_011278
NM_001304269
NM_001304270

RefSeq (protein)

NP_001171938
NP_001171939
NP_002929

NP_001291198
NP_001291199
NP_035408

Location (UCSC) Chr 4: 2.46 – 2.63 Mb Chr 5: 34.49 – 34.51 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RING finger protein 4 is a protein that in humans is encoded by the RNF4 gene. [5] [6]

Contents

The protein encoded by this gene contains a RING finger domain and acts as a transcription factor. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. [6]

Interactions

RNF4 has been shown to interact with TCF20, [7] PATZ1 [8] [9] and Androgen receptor. [9] [10] [11]

See also

Related Research Articles

<span class="mw-page-title-main">Androgen receptor</span> Mammalian protein found in Homo sapiens

The androgen receptor (AR), also known as NR3C4, is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone, in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.

<span class="mw-page-title-main">Nuclear receptor co-repressor 2</span> Protein-coding gene in the species Homo sapiens

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression. NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT) or T3 receptor-associating cofactor 1 (TRAC-1).

<span class="mw-page-title-main">V-erbA-related gene</span> Protein-coding gene in the species Homo sapiens

V-erbA-related protein 2 (EAR-2) also known as NR2F6 is a protein that in humans is encoded by the NR2F6 gene. V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors. It is named after its similarity to v-erbA, a helper of an oncoprotein called v-erbB in avian erythroblastosis virus.

<span class="mw-page-title-main">RELA</span> Protein-coding gene in the species Homo sapiens

Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.

<span class="mw-page-title-main">TGFB1I1</span> Protein-coding gene in the species Homo sapiens

Transforming growth factor beta-1-induced transcript 1 protein is a protein that in humans is encoded by the TGFB1I1 gene. Often put together with and studied alongside TGFB1I1 is the mouse homologue HIC-5. As the name suggests, TGFB1I1 is an induced form of the larger family of TGBF1. Studies suggest TGBF1I1 plays a role in processes of cell growth, proliferation, migration, differentiation and senescence. TGBF1I1 is most localized at focal adhesion complexes of cells, although it may be found active in the cytosol, nucleus and cell membrane as well.

<span class="mw-page-title-main">TRAF5</span> Protein-coding gene in the species Homo sapiens

TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.

<span class="mw-page-title-main">TRIM28</span> Protein-coding gene in the species Homo sapiens

Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1, is a protein that in humans is encoded by the TRIM28 gene.

<span class="mw-page-title-main">SUMO2</span> Protein-coding gene in the species Homo sapiens

Small ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene.

<span class="mw-page-title-main">COUP-TFI</span> Protein-coding gene in the species Homo sapiens

COUP-TF1 also known as NR2F1 is a protein that in humans is encoded by the NR2F1 gene. This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

<span class="mw-page-title-main">PIAS1</span> Protein-coding gene in the species Homo sapiens

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.

<span class="mw-page-title-main">Protein inhibitor of activated STAT2</span> Protein-coding gene in the species Homo sapiens

E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene.

<span class="mw-page-title-main">PIAS3</span> Protein-coding gene in the species Homo sapiens

E3 SUMO-protein ligase PIAS3 is an enzyme that in humans is encoded by the PIAS3 gene.

<span class="mw-page-title-main">SNRPN upstream reading frame protein</span> Protein-coding gene in the species Homo sapiens

SNRPN upstream reading frame protein is a protein that in humans is encoded by the SNURF gene.

<span class="mw-page-title-main">GRIP1 (gene)</span> Protein-coding gene in the species Homo sapiens

Glutamate receptor-interacting protein 1 is a protein that in humans is encoded by the GRIP1 gene.

<span class="mw-page-title-main">CITED2</span> Protein-coding gene in the species Homo sapiens

Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded by the CITED2 gene.

<span class="mw-page-title-main">RNF14</span> Protein-coding gene in the species Homo sapiens

E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.

<span class="mw-page-title-main">RNF8</span> Protein-coding gene in the species Homo sapiens

E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene. RNF8 has activity both in immune system functions and in DNA repair.

<span class="mw-page-title-main">PATZ1</span> Protein-coding gene in the species Homo sapiens

POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene.

<span class="mw-page-title-main">TCF20</span> Protein-coding gene in the species Homo sapiens

Transcription factor 20 is a protein that in humans is encoded by the TCF20 gene.

<span class="mw-page-title-main">ZNF10</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 10 is a protein that in humans is encoded by the ZNF10 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000063978 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029110 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Chiariotti L, Benvenuto G, Fedele M, Santoro M, Simeone A, Fusco A, Bruni CB (Jan 1998). "Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3". Genomics. 47 (2): 258–65. doi:10.1006/geno.1997.5105. PMID   9479498.
  6. 1 2 "Entrez Gene: RNF4 ring finger protein 4".
  7. ↑ Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P (Aug 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". The Journal of Biological Chemistry. 275 (34): 26144–9. doi: 10.1074/jbc.M003405200 . PMID   10849425.
  8. ↑ Fedele M, Benvenuto G, Pero R, Majello B, Battista S, Lembo F, Vollono E, Day PM, Santoro M, Lania L, Bruni CB, Fusco A, Chiariotti L (Mar 2000). "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor". The Journal of Biological Chemistry. 275 (11): 7894–901. doi: 10.1074/jbc.275.11.7894 . PMID   10713105.
  9. 1 2 Pero R, Lembo F, Palmieri EA, Vitiello C, Fedele M, Fusco A, Bruni CB, Chiariotti L (Feb 2002). "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription". The Journal of Biological Chemistry. 277 (5): 3280–5. doi: 10.1074/jbc.M109491200 . PMID   11719514.
  10. ↑ Moilanen AM, Poukka H, Karvonen U, Häkli M, Jänne OA, Palvimo JJ (Sep 1998). "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription". Molecular and Cellular Biology. 18 (9): 5128–39. doi:10.1128/mcb.18.9.5128. PMC   109098 . PMID   9710597.
  11. ↑ Poukka H, Aarnisalo P, Santti H, Jänne OA, Palvimo JJ (Jan 2000). "Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms". The Journal of Biological Chemistry. 275 (1): 571–9. doi: 10.1074/jbc.275.1.571 . PMID   10617653.

Further reading

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