Type 2 diabetes (T2D), formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent urination, fatigue and unexplained weight loss. Symptoms may also include increased hunger, having a sensation of pins and needles, and sores (wounds) that do not heal. Often symptoms come on slowly. Long-term complications from high blood sugar include heart disease, strokes, diabetic retinopathy which can result in blindness, kidney failure, and poor blood flow in the limbs which may lead to amputations. The sudden onset of hyperosmolar hyperglycemic state may occur; however, ketoacidosis is uncommon.
University College Hospital (UCH) is a teaching hospital in the Fitzrovia area of the London Borough of Camden, England. The hospital, which was founded as the North London Hospital in 1834, is closely associated with University College London (UCL), whose main campus is situated next door. The hospital is part of the University College London Hospitals NHS Foundation Trust.
Ghrelin is a hormone primarily produced by enteroendocrine cells of the gastrointestinal tract, especially the stomach, and is often called a "hunger hormone" because it increases the drive to eat. Blood levels of ghrelin are highest before meals when hungry, returning to lower levels after mealtimes. Ghrelin may help prepare for food intake by increasing gastric motility and stimulating the secretion of gastric acid.
Bariatrics is the branch of medicine that deals with the causes, prevention, and treatment of obesity.
Sleeve gastrectomy or vertical sleeve gastrectomy, is a surgical weight-loss procedure, typically performed laparoscopically, in which approximately 75 - 85% of the stomach is removed, along the greater curvature, which leaves a cylindrical, or "sleeve"-shaped stomach the size of a banana. Weight loss is affected not only through the reduction of the organ's size, but by the removal of the portion of it that produces ghrelin, the hormone that stimulates appetite. Patients can lose 50-70 percent of excess weight over the course of the two years that follow the surgery. The procedure is irreversible, though in some uncommon cases, patients can regain the lost weight, via resumption of poor dietary habits, or dilation of the stomach over time, which can require gastric sleeve revision surgery to either repair the sleeve or convert it to another type of weight loss method that may produce better results, such as a gastric bypass or duodenal switch.
Bariatric surgery is a medical term for surgical procedures used to manage obesity and obesity-related conditions. Long term weight loss with bariatric surgery may be achieved through alteration of gut hormones, physical reduction of stomach size, reduction of nutrient absorption, or a combination of these. Standard of care procedures include Roux en-Y bypass, sleeve gastrectomy, and biliopancreatic diversion with duodenal switch, from which weight loss is largely achieved by altering gut hormone levels responsible for hunger and satiety, leading to a new hormonal weight set point.
The American Society for Metabolic & Bariatric Surgery (ASMBS) is a non-profit medical organization dedicated to metabolic and bariatric surgery, and obesity-related diseases and conditions. It was established in 1983.
George L. Blackburn was the S. Daniel Abraham Professor of Nutrition and associate director of the division of nutrition at Harvard Medical School. He was also director of the Center for the Study of Nutrition Medicine (CSNM) in the Roberta and Stephen R. Weiner Department of Surgery, and director of the new Feihe Nutrition Laboratory at Beth Israel Deaconess Medical Center (BIDMC), Boston, Massachusetts.
Karen Teff is a biologist and geneticist. She received her education in Canada and has since been working in the United States. Teff has spent most of her career studying the effects of diabetes and other related diseases on humans.
Susie (Sue) Pedersen is a Canadian physician, a Specialist in Endocrinology & Metabolism, and a Diplomate of the American Board of Obesity Medicine. She is a member of the Expert Committee for the Diabetes Canada Clinical Practice Guidelines as a coauthor on the Weight Management Chapter. She is also lead author of the pharmacotherapy chapter of the 2019 Obesity Canada Clinical Practice Guidelines. She published the first randomized controlled trial on a portion control toll for weight loss.
The UCLH Biomedical Research Centre is a biomedical research centre based in London. It is a partnership between University College London Hospitals NHS Foundation Trust (UCLH), University College London (UCL) the National Institute for Health and Care Research (NIHR) and UCLPartners. It was one of the original five Comprehensive Biomedical Research Centres established by the NIHR in April 2007.
Management of obesity can include lifestyle changes, medications, or surgery. Although many studies have sought effective interventions, there is currently no evidence-based, well-defined, and efficient intervention to prevent obesity.
Matthias H. Tschöp is a German physician and scientist. He is the chief executive officer and scientific director of Helmholtz Zentrum München, German Research Center for Environmental Health. He is also Alexander von Humboldt Professor and chair of metabolic diseases at Technical University of Munich and serves as an adjunct professor at Yale University.
Sir Stephen Robert Bloom FRS is a British Professor of Medicine at Imperial College London where he leads the Diabetes, Endocrinology and Metabolism division.
Ramani Moonesinghe OBE MD(Res) FRCP FRCA FFICM SFFMLM is Professor of Perioperative Medicine at University College London (UCL) and a Consultant in Anaesthetics and Critical Care Medicine at UCL Hospitals. Moonesinghe was Director of the National Institute for Academic Anaesthesia (NIAA) Health Services Research Centre between 2016 and 2022, and between 2016 and 2019 was Associate National Clinical Director for Elective Care for NHS England. In 2020 on she took on the role of National Clinical Director for Critical and Perioperative care at NHS England and NHS Improvement.
Nita Gandhi Forouhi is a British physician and academic, specialising in nutrition and epidemiology. She is Professor of Population Health and Nutrition at the University of Cambridge, the programme leader of the nutritional epidemiology programme of its MRC Epidemiology Unit, and an honorary consultant public health physician with Public Health England.
Elizabeth Murray was a British general practitioner and professor of e-health and primary care at University College London. In 2003 she established the eHealth Unit at UCL where she was co-director, and she was also Deputy Director of the UCL Institute of Healthcare Engineering.
Russell Mardon Viner, FMedSci is an Australian-British paediatrician and policy researcher who is Chief Scientific Advisor at the Department for Education and Professor of Adolescent Health at the UCL Great Ormond Street Institute of Child Health. He is an expert on child and adolescent health in the UK and internationally. He was a member of the UK Government's Scientific Advisory Group for Emergencies (SAGE) during the COVID-19 pandemic and was President of the Royal College of Paediatrics and Child Health from 2018 to 2021. He remains clinically active, seeing young people with diabetes each week at UCL Hospitals. Viner is Vice-Chair of the NHS England Transformation Board for Children and Young People and Chair of the Stakeholder Council for the Board. He is a non-executive director (NED) at Great Ormond St. Hospital for Children NHS Foundation Trust, also sitting on the Trust's Finance & Investment and the Quality and Safety sub-committees.
Fatima Cody Stanford is an American obesity medicine physician, internist, and pediatrician and an associate professor of medicine and pediatrics at Harvard Medical School. She is one of the most highly cited scientists in the field of obesity. She is recognized for shifting the global perception of obesity as a chronic disease.
Edward Eaton Mason was an American surgeon, professor, and medical researcher who specialized in obesity surgery. He is known for developing restrictive gastric surgery for morbidly obese patients. Mason introduced the first gastric bypass surgery in 1966 and was the inventor of the first vertical banded gastroplasty surgery in 1980.
