SEPT8

SEPTIN8
Identifiers
Aliases	SEPTIN8 , SEP2, septin 8, SEPT8
External IDs	OMIM: 608418 MGI: 894310 HomoloGene: 57205 GeneCards: SEPTIN8
Gene location (Human)
Chr.	Chromosome 5 (human)
End	132,807,241 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	53,440,392 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; corpus callosum; ; inferior ganglion of vagus nerve; ; postcentral gyrus; ; entorhinal cortex; ; subthalamic nucleus; ; substantia nigra; ; superior frontal gyrus;
	Top expressed in
	facial motor nucleus; ; visual cortex; ; superior frontal gyrus; ; interventricular septum; ; cerebellar cortex; ; Region I of hippocampus proper; ; primary motor cortex; ; anterior horn of spinal cord; ; temporal lobe; ; piriform cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; GTP binding ; protein binding ; GTPase activity ; molecular adaptor activity ;
Cellular component	cytoplasm ; cytoskeleton ; septin ring ; microtubule cytoskeleton ; septin complex ; septin filament array ; presynapse ; membrane ; cell junction ; axon ; synaptic vesicle membrane ; cytoplasmic vesicle ; cell projection ; synapse ;
Biological process	mitotic cytokinesis ; septin ring assembly ; cilium assembly ; regulation of SNARE complex assembly ; cytoskeleton-dependent cytokinesis ;
	Sources:Amigo / QuickGO
Orthologs
	23176
	20362
	ENSG00000164402
	ENSMUSG00000018398
	Q92599
	Q8CHH9
NM_001098811 ; NM_001098812 ; NM_001098813 ; NM_001300798 ; NM_001300799 ;
	NM_015146
NM_001252332 ; NM_001252333 ; NM_033144 ; NM_001347496 ; NM_001361968 ;
	NM_001361969
NP_001092281 ; NP_001092282 ; NP_001092283 ; NP_001287727 ; NP_001287728 ;
	NP_055961
NP_001239261 ; NP_001239262 ; NP_001334425 ; NP_149156 ; NP_001348897 ;
	NP_001348898
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated May 13, 2024

Septin-8 is a protein that in humans is encoded by the SEPT8 gene.^[5]^[6]^[7]

Function

SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking.^[7]

Interactions

SEPT8 has been shown to interact with PFTK1 ^[8] and SEPT5.^[9]^[10]

Related Research Articles

Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The CDX2 protein is a homeobox transcription factor expressed in the nuclei of intestinal epithelial cells, playing an essential role in the development and function of the digestive system. CDX2 is part of the ParaHox gene cluster, a group of three highly conserved developmental genes present in most vertebrate species. Together with CDX1 and CDX4, CDX2 is one of three caudal-related genes in the human genome.

Septin 2, also known as SEPT2, is a protein which in humans is encoded by the SEPT2 gene.

Septin-5 is a protein that in humans is encoded by the SEPT5 gene.

Septin-4 is a protein that in humans is encoded by the SEPT4 gene.

N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.

Septin-6 is a protein that in humans is encoded by the SEPT6 gene.

Septin-7 is a protein that in humans is encoded by the SEPT7 gene.

Ubiquitin-associated protein 1 is a protein that in humans is encoded by the UBAP1 gene.

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT9 gene.

Secretogranin III, also known as SCG3, is a protein which in humans is encoded by the SCG3 gene.

Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene.

Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the CDK14 gene.

Septin-11 is a protein that in humans is encoded by the SEPT11 gene.

Neuronal-specific septin-3 is a protein that in humans is encoded by the SEPT3 gene.

Synapse-associated protein 1 is a protein that in humans is encoded by the SYAP1 gene.

Septin-1 is a protein that in humans is encoded by the SEPTIN1 gene. It was renamed from SEPT1 to avoid problems where Microsoft Excel would auto-correct the gene name to the date September 1.

Probable ATP-dependent RNA helicase DHX36 also known as DEAH box protein 36 (DHX36) or MLE-like protein 1 (MLEL1) or G4 resolvase 1 (G4R1) or RNA helicase associated with AU-rich elements (RHAU) is an enzyme that in humans is encoded by the DHX36 gene.

T-complex protein 11 homolog is a protein that in humans is encoded by the TCP11 gene.

RANBP2-like and GRIP domain-containing protein 5 is a protein that in humans is encoded by the RGPD5 gene.

Septin 12 is a protein that in humans is encoded by the SEPT12 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164402 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018398 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID 9039502.
↑ Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM (May 1997). "Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region". Genome Research. 7 (5): 495–512. doi: 10.1101/gr.7.5.495 . PMID 9149945.
1 2 "Entrez Gene: SEPT8 septin 8".
↑ Yang T, Gao YK, Chen JY (July 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 520–5. PMID 12098780.
↑ Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
↑ Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. Bibcode:2002FEBSL.519..169B. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038. S2CID 30822245.

Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Wenderfer SE, Slack JP, McCluskey TS, Monaco JJ (February 2000). "Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11". Genomics. 63 (3): 354–73. doi:10.1006/geno.1999.6100. PMID 10704283.
Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. Bibcode:2002FEBSL.519..169B. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038. S2CID 30822245.
Yang T, Gao YK, Chen JY (July 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 520–5. PMID 12098780.
Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, Petty EM, Peifer M, Pringle JR, Robinson PJ, Roth D, Russell SE, Stuhlmann H, Tanaka M, Tanaka T, Trimble WS, Ware J, Zeleznik-Le NJ, Zieger B (December 2002). "Mammalian septins nomenclature". Molecular Biology of the Cell. 13 (12): 4111–3. doi:10.1091/mbc.E02-07-0438. PMC 138619 . PMID 12475938.
Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
Bläser S, Horn J, Würmell P, Bauer H, Strümpell S, Nurden P, Pagenstecher A, Busse A, Wunderle D, Hainmann I, Zieger B (May 2004). "The novel human platelet septin SEPT8 is an interaction partner of SEPT4". Thrombosis and Haemostasis. 91 (5): 959–66. doi:10.1160/TH03-09-0578. PMID 15116257. S2CID 22853459.
Martínez C, Sanjuan MA, Dent JA, Karlsson L, Ware J (September 2004). "Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol". The Biochemical Journal. 382 (Pt 3): 783–91. doi:10.1042/BJ20040372. PMC 1133953 . PMID 15214843.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Bläser S, Röseler S, Rempp H, Bartsch I, Bauer H, Lieber M, Lessmann E, Weingarten L, Busse A, Huber M, Zieger B (September 2006). "Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5". The Journal of Pathology. 210 (1): 103–10. doi:10.1002/path.2013. PMID 16767699. S2CID 45797279.
Xin X, Pache M, Zieger B, Bartsch I, Prünte C, Flammer J, Meyer P (November 2007). "Septin expression in proliferative retinal membranes". The Journal of Histochemistry and Cytochemistry. 55 (11): 1089–94. doi:10.1369/jhc.7A7188.2007. PMC 3957527 . PMID 17625225.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164402 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018398 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9039502-5] Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID 9039502.

[pmid9149945-6] Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM (May 1997). "Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region". Genome Research. 7 (5): 495–512. doi: 10.1101/gr.7.5.495 . PMID 9149945.

[entrez-7] 1 2 "Entrez Gene: SEPT8 septin 8".

[pmid12098780-8] Yang T, Gao YK, Chen JY (July 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 520–5. PMID 12098780.

[pmid12909369-9] Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.

[pmid12023038-10] Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. Bibcode:2002FEBSL.519..169B. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038. S2CID 30822245.

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SEPT8

Contents

Function

Interactions

Related Research Articles

References

Further reading