SH3KBP1

Last updated
SH3KBP1
Protein SH3KBP1 PDB 1wi7.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SH3KBP1 , CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18, SH3 domain containing kinase binding protein 1, IMD61, AGMX2
External IDs OMIM: 300374 MGI: 1889583 HomoloGene: 10971 GeneCards: SH3KBP1
Orthologs
SpeciesHumanMouse
Entrez

30011

58194

Ensembl

ENSG00000147010

ENSMUSG00000040990

UniProt

Q96B97
Q5JPT2

Q8R550

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr X: 19.53 – 19.89 Mb Chr X: 158.41 – 158.76 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SH3 domain-containing kinase-binding protein 1 (synonyms - CIN85 [5] , in rodents - Ruk [6] ) is an adaptor protein that in humans is encoded by the SH3KBP1 gene. [7] [8]

Function

CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM] [9]

Interactions

SH3KBP1 has been shown to interact with B-cell linker, [10] Grb2, [11] [12] SH3GLB2, [13] [14] SH3GL3, [13] SH3GL2, [14] BCAR1, [10] Epidermal growth factor receptor, [14] [15] CBLB, [15] Cbl gene, [10] [12] [13] [14] [15] SOS1, [10] CRK [10] and PAK2. [16]

Related Research Articles

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The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands.

<span class="mw-page-title-main">GRB2</span> Protein-coding gene in the species Homo sapiens

Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.

<span class="mw-page-title-main">Amphiphysin</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Adapter molecule crk</span> Protein-coding gene in the species Homo sapiens

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.

<span class="mw-page-title-main">PIK3R1</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.

<span class="mw-page-title-main">CBL (gene)</span> Mammalian gene

Cbl is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.

<span class="mw-page-title-main">CRKL</span> Protein-coding gene in the species Homo sapiens

Crk-like protein is a protein that in humans is encoded by the CRKL gene.

<span class="mw-page-title-main">PIK3R2</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.

<span class="mw-page-title-main">CBLB (gene)</span> Protein-coding gene in the species Homo sapiens

CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family.

<span class="mw-page-title-main">NCK1</span> Protein-coding gene in the species Homo sapiens

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.

<span class="mw-page-title-main">TANK-binding kinase 1</span> Protein-coding gene in the species Homo sapiens

TBK1 is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. It is encoded by the TBK1 gene in humans. This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. Insufficient regulation of TBK1 activity leads to autoimmune, neurodegenerative diseases or tumorigenesis.

<span class="mw-page-title-main">GRAP2</span> Protein-coding gene in the species Homo sapiens

GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2 gene.

<span class="mw-page-title-main">SH3GL2</span> Protein-coding gene in the species Homo sapiens

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.

<span class="mw-page-title-main">CD2AP</span> Protein

CD2-associated protein is a protein that in humans is encoded by the CD2AP gene.

<span class="mw-page-title-main">NCK2</span> Protein-coding gene in the species Homo sapiens

Cytoplasmic protein NCK2 is a protein that in humans is encoded by the NCK2 gene.

<span class="mw-page-title-main">SORBS2</span> Protein-coding gene in the species Homo sapiens

ArgBP2 protein, also referred to as Sorbin and SH3 domain-containing protein 2 is a protein that in humans is encoded by the SORBS2 gene. ArgBP2 belongs to the a small family of adaptor proteins having sorbin homology (SOHO) domains. ArgBP2 is highly abundant in cardiac muscle cells at sarcomeric Z-disc structures, and is expressed in other cells at actin stress fibers and the nucleus.

<span class="mw-page-title-main">SH3GL3</span> Protein-coding gene in the species Homo sapiens

Endophilin-A3 is a protein that in humans is encoded by the SH3GL3 gene.

<span class="mw-page-title-main">SH3GL1</span> Protein-coding gene in the species Homo sapiens

Endophilin-A2 is a protein that in humans is encoded by the SH3GL1 gene.

<span class="mw-page-title-main">CBLC</span> Protein-coding gene in the species Homo sapiens

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

<span class="mw-page-title-main">SH3GLB2</span> Protein-coding gene in the species Homo sapiens

Endophilin-B2 is a protein that in humans is encoded by the SH3GLB2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000147010 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040990 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Database GH. "SH3KBP1 Gene - GeneCards | SH3K1 Protein | SH3K1 Antibody". www.genecards.org. Retrieved 2017-12-28.
  6. ↑ Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". The EMBO Journal. 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. PMC   306608 . PMID   10921882.
  7. ↑ Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, et al. (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
  8. ↑ Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID   7566098.
  9. ↑ "Entrez Gene: SH3KBP1 SH3-domain kinase binding protein 1".
  10. 1 2 3 4 5 Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S (November 2000). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochemical and Biophysical Research Communications. 278 (1): 167–74. doi:10.1006/bbrc.2000.3760. PMID   11071869.
  11. ↑ Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". The EMBO Journal. 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. PMC   306608 . PMID   10921882.
  12. 1 2 Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O (December 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cellular Signalling. 12 (11–12): 769–79. doi:10.1016/S0898-6568(00)00129-7. PMID   11152963.
  13. 1 2 3 Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. Bibcode:2002Natur.416..187P. doi:10.1038/416187a. PMID   11894096. S2CID   4389099.
  14. 1 2 3 4 Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. Bibcode:2002Natur.416..183S. doi:10.1038/416183a. PMID   11894095. S2CID   635702.
  15. 1 2 3 Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". The Journal of Biological Chemistry. 277 (42): 39666–72. doi: 10.1074/jbc.M205535200 . PMID   12177062.
  16. ↑ Kurakin AV, Wu S, Bredesen DE (September 2003). "Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening". The Journal of Biological Chemistry. 278 (36): 34102–9. doi: 10.1074/jbc.M305264200 . PMID   12829691.

Further reading

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