SOCS4

SOCS4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IZV
Identifiers
Aliases	SOCS4 , SOCS7, suppressor of cytokine signaling 4
External IDs	OMIM: 616337 MGI: 1914546 HomoloGene: 15442 GeneCards: SOCS4
Gene location (Human)
Chr.	Chromosome 14 (human)
End	55,049,489 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	47,533,559 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; tibia; ; visceral pleura; ; parietal pleura; ; germinal epithelium; ; tibialis anterior muscle; ; caput epididymis; ; palpebral conjunctiva; ; secondary oocyte; ; thymus;
	Top expressed in
	medial ganglionic eminence; ; conjunctival fornix; ; carotid body; ; atrioventricular valve; ; lymph node; ; trigeminal ganglion; ; hair follicle; ; parotid gland; ; atrium; ; left lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase inhibitor activity ; protein binding ;
Cellular component	cytoplasm ; intracellular anatomical structure ;
Biological process	negative regulation of epidermal growth factor-activated receptor activity ; regulation of growth ; negative regulation of signal transduction ; intracellular signal transduction ; positive regulation of proteasomal ubiquitin-dependent protein catabolic process ; protein ubiquitination ; cytokine-mediated signaling pathway ; negative regulation of receptor signaling pathway via JAK-STAT ;
	Sources:Amigo / QuickGO
Orthologs
	122809
	67296
	ENSG00000180008
	ENSMUSG00000048379
	Q8WXH5
	Q91ZA6
	NM_080867 ; NM_199421
	NM_080843
	NP_543143 ; NP_955453
	NP_543119
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.^[5]

Function

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Related Research Articles

The interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.

Interleukin 28 receptor, alpha subunit is a subunit for the interleukin-28 receptor. IL28RA is its human gene.

Suppressor of cytokine signaling 3 is a protein that in humans is encoded by the SOCS3 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene. SOCS1 orthologs have been identified in several mammals for which complete genome data are available.

Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene. FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes in birds and mammals.

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.

Cytokine-inducible SH2-containing protein is a protein that in humans is encoded by the CISH gene. CISH orthologs have been identified in most mammals with sequenced genomes. CISH controls T cell receptor (TCR) signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria.

Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.

Ankyrin repeat and SOCS box protein 2 is a protein that in humans is encoded by the ASB2 gene.

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.

Interferon-induced 35 kDa protein is a protein that in humans is encoded by the IFI35 gene.

Interferon alpha-4 is a protein that in humans is encoded by the IFNA4 gene.

Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.

Ankyrin repeat and SOCS box protein 3 is a protein that in humans is encoded by the ASB3 gene.

Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs have been identified in most placentals for which complete genome data are available.

Ankyrin repeat and SOCS box protein 1 is a protein that is in humans, encoded by the ASB1 gene.

Ankyrin repeat and SOCS box protein 13 is a protein that in humans is encoded by the ASB13 gene.

Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene.

GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene.

Suppressor APC domain containing 1 is a protein that in humans is encoded by the SAPCD1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000180008 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048379 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Suppressor of cytokine signaling 4" . Retrieved 2016-02-23.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Suppressor of cytokine signaling 4 (SOCS4)

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000180008 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048379 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Suppressor of cytokine signaling 4" . Retrieved 2016-02-23.

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SOCS4

Contents

Function

Related Research Articles

References

Further reading

External links